Dry powder platform for pulmonary drug delivery

Particuology

Volumn 6, Issue 4, 2008, Pages 225-238

  Daniher, Derek Ivan ^a   Zhu, Jesse ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Aerosol; Carrier particle; Dry powder inhaler; Fluidization; Interparticle forces; Pulmonary drug delivery

Indexed keywords

BIOLOGICAL ORGANS; CHEMOTHERAPY; CRYSTALS; CURING; DRUG DELIVERY; DRUG DOSAGE; DRUG INTERACTIONS; DRYING; FLOW OF FLUIDS; FLUID DYNAMICS; FLUID MECHANICS; FLUIDIZATION; HEALTH; POWDERS; PROCESS ENGINEERING; PRODUCTION ENGINEERING; RESEARCH; VAN DER WAALS FORCES; VOLCANIC ROCKS;

ADVANCED DESIGNS; BASIC CONCEPTS; CHINESE ACADEMY OF SCIENCES (CAS); CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD); CYSTIC FIBROSIS (CF); DRY POWDERS; DRY-POWDER INHALER (DPI); FLOW-ABILITY; HIGH DOSE; INSTITUTE OF PROCESS ENGINEERING (IPE); PARTICLE TECHNOLOGY; PULMONARY DRUG DELIVERY; VAN DER WAALS ATTRACTION;

CONTROLLED DRUG DELIVERY;

EID: 48049116416     PISSN: 16742001     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.partic.2008.04.004     Document Type: Review

References (144)

1. Abbas A., Srour M., Tang P., Chiou H., Chan H., and Romagnoli J.A. Sonocrystallisation of sodium chloride particles for inhalation. Chemical Engineering Science 62 9 (2007) 2445-2453
2. Alavi S., and Caussat B. Experimental study on fluidization of micronic powders. Powder Technology 157 1-3 (2005) 114-120
3. Bakhbakhi Y., Charpentier P.A., and Rohani S. Experimental study of the GAS process for producing microparticles of beclomethasone-17-21-dipropionate suitable for pulmonary delivery. International Journal of Pharmaceutics 309 1-2 (2006) 71-80
4. Baldrick P., and Bamford D.G. A toxicological review of lactose to support clinical administration by inhalation. Food and Chemical Toxicology 35 7 (1997) 719-733
5. Begat P., Morton D.A.V., Staniforth J.N., and Price R. The cohesive-adhesive balances in dry powder inhaler formulations. I. Direct quantification by atomic force microscopy. Pharmaceutical Research 21 9 (2004) 1591-1597
6. Begat P., Price R., Harris H., Morton D.A.V., and Staniforth J.N. The influence of force control agents on the cohesive-adhesive balance in dry powder inhaler formulations. KONA 23 (2005) 109-121
7. Bisgaard H. Automatic actuation of a dry powder inhaler into a nonelectrostatic spacer. American Journal of Respiratory and Critical Care Medicine 157 2 (1998) 518-521
8. Bisgaard H. Future options for aerosol delivery to children. Allergy 54 Suppl. 49 (1999) 97-103
9. Bivas-Benita M., Zwier R., Junginger H.E., and Borchard G. Non-invasive pulmonary aerosol delivery in mice by the endotracheal route. European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 61 3 (2005) 214-218
10. Brown D.P., Kauppinen E.I., and Jokiniemi J.K. Agglomerate deaggregation potential during dry powder inhaler operation and characterization under steady and unsteady conditions. Journal of Aerosol Science 34 (2003) 1417-1428
11. Chan H. Dry powder aerosol drug delivery-opportunities for colloid and surface scientists. Colloids and Surfaces A: Physicochemical and Engineering Aspects 284-285 (2006) 50-55
12. Chen B.T., Yeh H.T., and Fan B.J. Evaluation of the TSI small-scale powder disperser. Journal of Aerosol Science 26 8 (1995) 1303-1313
13. Chew N.Y.K., Tang P., Chan H., and Raper J.A. How much particle surface corrugation is sufficient to improve aerosol performance of powders?. Pharmaceutical Research 22 1 (2005) 148-152
14. Chirone R., and Massimilla L. Sound-assisted aeration of beds of cohesive solids. Chemical Engineering Science 49 8 (1994) 1185-1194
15. Chirone R., Massimilla L., and Russo S. Bubble-free fluidization of a cohesive powder in an acoustic field. Chemical Engineering Science 48 1 (1993) 41-52
16. Chow A.H.L., Tong H.H.Y., Chattopadhyay P., and Shekunov B.Y. Particle engineering for pulmonary drug delivery. Pharmaceutical Research 24 3 (2007) 411-437
17. Chrystyn H. The diskus: A review of its position among dry powder inhaler devices. International Journal of Clinical Practice 61 6 (2007) 1022-1036
18. Coates M.S., Chan H.K., Fletcher D.F., and Chiou H. Influence of mouthpiece geometry on the aerosol delivery performance of a dry powder inhaler. Pharmaceutical Research 24 8 (2007) 1450-1456
19. Coates M.S., Chan H.K., Fletcher D.F., and Raper J.A. Influence of air flow on the performance of a dry powder inhaler using computational and experimental analyses. Pharmaceutical Research 22 9 (2005) 1445-1453
20. Coates M.S., Chan H.K., Fletcher D.F., and Raper J.A. Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 2: Air inlet size. Journal of Pharmaceutical Sciences 95 6 (2006) 1382-1392
21. Coates M.S., Fletcher D.F., Chan H.K., and Raper J.A. Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 1: Grid structure and mouthpiece length. Journal of Pharmaceutical Sciences 93 11 (2004) 2863-2876
22. Coates M.S., Fletcher D.F., Chan H.K., and Raper J.A. The role of capsule on the performance of a dry powder inhaler using computational and experimental analyses. Pharmaceutical Research 22 6 (2005) 923-932
23. Crowder T., and Hickey A. Powder specific active dispersion for generation of pharmaceutical aerosols. International Journal of Pharmaceutics 327 1-2 (2006) 65-72
24. Dahl R., Backer V., Ollgaard B., Gerken F., and Kesten S. Assessment of patient performance of the HandiHaler compared with the metered dose inhaler four weeks after instruction. Respiratory Medicine 97 10 (2003) 1126-1133
25. de Boer A.H., Hagedoorn P., Gjaltema D., Goede J., and Frijlink H.W. Air classifier technology (ACT) in dry powder inhalation. Part 3. Design and development of an air classifier family for the novolizer(R) multi-dose dry powder inhaler. International Journal of Pharmaceutics 310 1-2 (2006) 72-80
26. de Boer A.H., Le Brun P.P.H., van der Woude H.G., Hagedoorn P., Heijerman H.G.M., and Frijlink H.W. Dry powder inhalation of antibiotics in cystic fibrosis therapy. Part 1: Development of a powder formulation with colistin sulfate for a special test inhaler with an air classifier as de-agglomeration principle. European Journal of Pharmaceutics and Biopharmaceutics 54 1 (2002) 17-24
27. Dolovich M.A. Influence of inspiratory flow rate, particle size, and airway caliber on aerosolized drug delivery to the lung. Respiratory Care 45 6 (2000) 597-608
28. Dunbar C.A., Hickey A.J., and Holzner P. Dispersion and characterization of pharmaceutical dry powder aerosols. KONA 16 (1998) 7-45
29. Dutta A., and Dullea L.V. Comparative evaluation of negatively and positively charged submicron particles as flow conditioners for a cohesive powder. Advances in Fluidization Engineering, San Francisco, CA, USA 86 276 (1990) 26-40
30. Dutta A., and Dullea L.V. Effects of external vibration and the addition of fibers on the fludization of a fine powder. Fluidization and Fluid-Particle Systems, Chicago, IL, USA 87 281 (1991) 38-46
31. Edwards D.A., Hanes J., Caponetti G., Hrkach J., Ben-Jebria A., Eskew M.L., et al. Large porous particles for pulmonary drug delivery. Science (New York, N.Y.) 276 5320 (1997) 1868-1871
32. Everard M.L., Devadason S.G., and Le Souef P.N. Particle size selection device for use with the turbohaler. Thorax 51 5 (1996) 537-539
33. Fink J.B. Metered-dose inhalers, dry powder inhalers, and transitions. Respiratory Care 45 6 (2000) 623-635
34. Finlay W.H. The mechanics of inhaled pharmaceutical aerosols (2001), Academic Press, San Diego
35. Franks M., and Briggs P. Use of a cognitive ergonomics approach to compare usabilityof a multidose dry powder inhaler and a capsule dry powder inhaler: An open-label, randomized, controlled study. Clinical Therapeutics 26 11 (2004) 1791-1799
36. French D.L., Edwards D.A., and Niven R.W. The influence of formulation on emission, deaggregation and deposition of dry powders for inhalation. Journal of Aerosol Science 27 5 (1996) 769-783
37. Fried E.M., and Wheelock T.D. Fluidized bed characteristics of wheat flour. Chemical Engineering Progress Symposium Series 62 69 (1966) 117
38. Garcia-Contreras L., Fiegel J., Telko M.J., Elbert K., Hawi A., Thomas M., et al. Inhaled large porous particles of capreomycin for treatment of tuberculosis in a guinea pig model. Antimicrobial Agents and Chemotherapy 51 8 (2007) 2830-2836
39. Geldart D. Types of gas fluidization. Powder Technology 7 5 (1973) 285-292
40. Geldart D., and Abrahamsen A.R. Homogeneous fluidization of fine powders using various gases and pressures. Powder Technology 19 (1978) 133-136
41. Gerde P., Ewing P., Lastbom L., and Ryrfeldt A. A novel method to aerosolize powder for short inhalation exposures at high concentrations: Isolated rat lungs exposed to respirable diesel soot. Inhalation Toxicology 16 1 (2004) 45-52
42. Gilani K., Najafabadi A.R., Barghi M., and Rafiee-Tehrani M. Aerosolisation of beclomethasone dipropionate using spray dried lactose/polyethylene glycol carriers. European Journal of Pharmaceutics and Biopharmaceutics 58 3 (2004) 595-606
43. Godard K., and Richardson J.F. The use of slow speed stirring to initiate particulate fluidization. Chemical Engineering Science 24 (1969) 194-195
44. Groneberg D.A., Witt C., Wagner U., Chung K.F., and Fischer A. Fundamentals of pulmonary drug delivery. Respiratory Medicine 97 4 (2003) 382-387
45. Guchardi R., Frei M., John E., and Kaerger J.S. Influence of fine lactose and magnesium stearate on low dose dry powder inhaler formulations. International Journal of Pharmaceutics 348 1-2 (2008) 10-17
46. Harper N.J., Gray S., De Groot J., Parker J.M., Sadrzadeh N., Schuler C., et al. The design and performance of the exubera pulmonary insulin delivery system. Diabetes Technology & Therapeutics 9 Suppl. 1 (2007) S16-S27
47. Heng D., Tang P., Cairney J.M., Chan H., Cutler D.J., Salama R., et al. Focused-ion-beam milling: A novel approach to probing the interior of particles used for inhalation aerosols. Pharmaceutical Research 24 9 (2007) 1608-1617
48. Hickey A.J., Mansour H.M., Telko M.J., Xu Z., Smyth H.D.C., Mulder T., et al. Physical characterization of component particles included in dry powder inhalers. I. Strategy review and static characteristics. Journal of Pharmaceutical Sciences 96 5 (2007) 1282-1301
49. Hickey A.J., Mansour H.M., Telko M.J., Xu Z., Smyth H.D.C., Mulder T., et al. Physical characterization of component particles included in dry powder inhalers. II. Dynamic characteristics. Journal of Pharmaceutical Sciences 96 5 (2007) 1302-1319
50. Hinds W.C. Aerosol technology: Properties, behaviour, and measurement of airborne particles. 2nd ed. (1999), Wiley, New York
51. Hollenbach A.M., Peleg M., and Rufner R. Interparticle surface affinity and the bulk properties of conditioned powders. Powder Technology 35 1 (1983) 51-62
52. Hooton J.C., Jones M.D., and Price R. Predicting the behavior of novel sugar carriers for dry powder inhaler formulations via the use of a cohesive-adhesive force balance approach. Journal of Pharmaceutical Sciences 95 6 (2006) 1288-1297
53. Hristov J. The fluidization in a magnetic field is more than 40 years old: It is time to strike the balance in front of the new century. Lavoisier Technique, Paris 14 75 (2000) 251-260
54. Huber G., and Wirth K.-E. Electrostatically supported surface coating of solid particles in liquid nitrogen for use in dry-powder-inhalers. Powder Technology 134 3 (2003) 181-192
55. Islam N., Stewart P., Larson I., and Hartley P. Effect of carrier size on the dispersion of salmeterol xinafoate from interactive mixtures. Journal of Pharmaceutical Sciences 93 4 (2004) 1030-1038
56. Islam N., Stewart P., Larson I., and Hartley P. Lactose surface modification by decantation: Are drug-fine lactose ratios the key to better dispersion of salmeterol xinafoate from lactose-interactive mixtures?. Pharmaceutical Research 21 3 (2004) 492-499
57. Islam N., Stewart P., Larson I., and Hartley P. Surface roughness contribution to the adhesion force distribution of salmeterol xinafoate on lactose carriers by atomic force microscopy. Journal of Pharmaceutical Sciences 94 7 (2005) 1500-1511
58. Jaraiz E., Kimura S., and Levenspiel O. Vibrating beds of fine particles. Estimation of interparticle forces from expansion and pressure drop experiments. Powder Technology 72 1 (1992) 23-30
59. Jones M.D., Hooton J.C., Dawson M.L., Ferrie A.R., and Price R. An investigation into the dispersion mechanisms of ternary dry powder inhaler formulations by the quantification of interparticulate forces. Pharmaceutical Research 25 2 (2008) 337-348
60. Jones M.D., and Price R. The influence of fine excipient particles on the performance of carrier-based dry powder inhalation formulations. Pharmaceutical Research 23 8 (2006) 1665-1674
61. Kato, K., Takarada, T., Koshinuma, A., Kanazawa, I., & Sugihara, T. (1989). Decarbonization of silicon carbide-carbon fine particles mixture in a fluidized bed. Fluidization VI.
62. Kato K., Takarada T., Matsuo N., Suto T., and Nakagawa N. Residence-time distribution of fine particles in a powder-particle fluidized bed. International Chemical Engineering 34 4 (1994) 605-610
63. Keskinen J., Pietarinen K., and Lehtimäki M. Electrical low pressure impactor. Journal of Aerosol Science 23 4 (1992) 353-360
64. Kono H.O., Huang C.C., and Xi M. Effect of flow conditioners on the tensile strength of cohesive powder structures. Fluidization and Fluid Particle Systems: Fundamentals and Applications, Washington, DC, USA 85 270 (1989) 44-48
65. Kremer D.M., and Hancock B.C. Process simulation in the pharmaceutical industry: A review of some basic physical models. Journal of Pharmaceutical Sciences 95 3 (2006) 517-529
66. Krupp H. Particle adhesion theory and experiment. Advances in Colloid and Interface Science 1 2 (1967) 111-239
67. Kurkela J.A., Brown D.P., Raula J., and Kauppinen E.I. New apparatus for studying powder deagglomeration. Powder Technology 180 1-2 (2008) 164-171
68. Kwon M.J., Bae J.H., Kim J.J., Na K., and Lee E.S. Long acting porous microparticle for pulmonary protein delivery. International Journal of Pharmaceutics 333 1-2 (2007) 5-9
69. Labiris N.R., and Dolovich M.B. Pulmonary drug delivery. Part I. Physiological factors affecting therapeutic effectiveness of aerosolized medications. British Journal of Clinical Pharmacology 56 6 (2003) 588-599
70. Labiris N.R., and Dolovich M.B. Pulmonary drug delivery. Part II. The role of inhalant delivery devices and drug formulations in therapeutic effectiveness of aerosolized medications. British Journal of Clinical Pharmacology 56 6 (2003) 600-612
71. Larhrib H., Martin G.P., Marriott C., and Prime D. The influence of carrier and drug morphology on drug delivery from dry powder formulations. International Journal of Pharmaceutics 257 1-2 (2003) 283-296
72. Larhrib H., Martin G.P., Prime D., and Marriott C. Characterisation and deposition studies of engineered lactose crystals with potential for use as a carrier for aerosolised salbutamol sulfate from dry powder inhalers. European Journal of Pharmaceutical Sciences 19 4 (2003) 211-221
73. Larhrib H., Zeng X.M., Martin G.P., Marriott C., and Pritchard J. The use of different grades of lactose as a carrier for aerosolised salbutamol sulphate. International Journal of Pharmaceutics 191 1 (1999) 1-14
74. 2 aerogels by reducing interparticle forces. Powder Technology 65 1-3 (1991) 461-468
75. Leong K.H. Theoretical principals and devices used to generate aerosols for research. In: Hickey A.J. (Ed). Pharmaceutical inhalation aerosol technology. 2nd rev and expanded. ed (2004), M. Dekker, New York 253-278
76. Liu Y.A., Hamby R.K., and Colberg R.D. Fundamental and practical developments of magnetofluidized beds. A review. Powder Technology 64 1-2 (1991) 3-41
77. Liu Y., and Kimura S. Fluidization and entrainment of difficult-to-fluidize fine powder mixed with easy-to-fluidize large particles. Powder Technology 75 2 (1993) 189-196
78. Louey M.D., Van Oort M., and Hickey A.J. Standardized entrainment tubes for the evaluation of pharmaceutical dry powder dispersion. Journal of Aerosol Science 37 11 (2006) 1520-1531
79. Ma X., Honda Y., Nakagawa N., and Kato K. Elutriation of fine powders from a fluidized bed of a binary particle-mixture. Journal of Chemical Engineering of Japan 29 2 (1996) 330-335
80. Ma X., and Kato K. Effect of interparticle adhesion forces on elutriation of fine powders from a fluidized bed of a binary particle mixture. Powder Technology 95 2 (1998) 93-101
81. Martin G.P., Marriott C., and Zeng X.M. Influence of realistic inspiratory flow profiles on fine particle fractions of dry powder aerosol formulations. Pharmaceutical Research 24 2 (2007) 361-369
82. Masuda H., and Gotoh K. Dry dispersion of fine particles. Colloids and Surfaces A: Physicochemical and Engineering Aspects 109 (1996) 29-37
83. Matida E.A., Finlay W.H., Rimkus M., Grgic B., and Lange C.F. A new add-on spacer design concept for dry-powder inhalers. Journal of Aerosol Science 35 7 (2004) 823-833
84. Mei R., Shang H., Klausner J.F., and Kallman E. A contact mode for the effect of particle coating on improving the flowability of cohesive powders. KONA 15 (1997) 132-141
85. Mendes P.J., Pinto J.F., and Sousa J.M.M. A non-dimensional functional relationship for the fine particle fraction produced by dry powder inhalers. Journal of Aerosol Science 38 6 (2007) 612-624
86. Mitchell J.P., Coppolo D.P., and Nagel M.W. Electrostatics and inhaled medications: Influence on delivery via pressurized metered-dose inhalers and add-on devices. Respiratory Care 52 3 (2007) 283-300
87. Mitchell J.P., and Nagel M.W. Particle size analysis of aerosols from medicinal inhalers. KONA 22 (2004) 32-65
88. Mitchell J.P., Nagel M.W., Nichols S., and Nerbrink O. Laser diffractometry as a technique for the rapid assessment of aerosol particle size from inhalers. Journal of Aerosol Medicine: The Official Journal of the International Society for Aerosols in Medicine 19 4 (2006) 409-433
89. Montz K.W., Beddow J.K., and Butler P.B. Adhesion and removal of particulate contaminants in a high-decibel acoustic field. Powder Technology 55 2 (1988) 133-140
90. Mori S., Yamamoto A., Iwata S., Haruta T., Yamada I., and Mizutani E. Vibro-fluidization of group-C particles and its industrial applications. Advances in Fluidization Engineering, San Francisco, CA, USA 86 276 (1990) 88-94
91. Morse R.D. Sonic energy in granular solid fluidization. Industrial and Engineering Chemistry 47 6 (1955) 1170-1175
92. Mueller-Walz, R., Fueg, L., Niederlaender, C., Pieles, U., & Wirth, A. (2006). Ternary additives: Manipulation and control with magnesium stearate: Vol. 1 (pp. 343-350). In Paper presented at the Respiratory Drug Delivery X. Boca Raton, Florida: Boca Raton Resort and Club. Retrieved Aug 16, 2006 from http://www.rddonline.com/.
93. Nakagawa N., Ohsawa K., Takarada T., and Kato K. Continuous drying of a fine particles-water slurry in a powder-particle fluidized bed. Journal of Chemical Engineering of Japan 25 5 (1992) 495-501
94. Nezzal, A., Large, J. F., & Guigon, P. (1998). Fluidisation behaviour of very cohesive powders under mechanical agitation. In Fluidization VIII, Proceedings of the Eighth Engineering Foundation Conference on Fluidization (pp. 77-82), May 14-19. Am. Inst. Chem. Eng.
95. Nowak W., Hasatani M., and Derczynski M. Fluidization and heat transfer of fine particles in an acoustic field. AIChE Symposium Series 89 296 (1993) 137-149
96. Pfeffer R., Dave R.N., Wei D., and Ramlakhan M. Synthesis of engineered particulates with tailored properties using dry particle coating. Powder Technology 117 1-2 (2001) 40-67
97. Piepers H.W., Cottaar E.J.E., Verkooijen A.H.M., and Rietema K. Effects of pressure and type of gas on particle-particle interaction and the consequences for gas-solid fluidization behaviour. Powder Technology 37 (1984) 55-70
98. Raeburn D., Underwood S.L., and Villamil M.E. Techniques for drug delivery to the airways, and the assessment of lung function in animal models. Journal of Pharmacological and Toxicological Methods 27 3 (1992) 143-159
99. Ramlakhan M., Wu C.Y., Watano S., Dave R.N., and Pfeffer R. Dry particle coating using magnetically assisted impaction coating: Modification of surface properties and optimization of system and operating parameters. Powder Technology 112 1-2 (2000) 137-148
100. Rau J.L. Practical problems with aerosol therapy in COPD. Respiratory Care 51 2 (2006) 158-172
101. Reed T.M., and Fenske M.R. Effect of agitation on gas fluidization of solids. Industrial and Engineering Chemistry 47 2 (1955) 275-282
102. Russo P., Chirone R., Massimilla L., and Russo S. The influence of the frequency of acoustic waves on sound-assisted fluidization of beds of fine particles. Powder Technology 82 3 (1995) 219-230
103. Sebti T., and Amighi K. Preparation and in vitro evaluation of lipidic carriers and fillers for inhalation. European Journal of Pharmaceutics and Biopharmaceutics 63 1 (2006) 51-58
104. Seville P.C., Learoyd T.P., Li H.Y., Williamson I.J., and Birchall J.C. Amino acid-modified spray-dried powders with enhanced aerosolisation properties for pulmonary drug delivery. Powder Technology 178 1 (2007) 40-50
105. Seville J.P.K., Willett C.D., and Knight P.C. Interparticle forces in fluidisation: A review. Powder Technology 113 3 (2000) 261-268
106. Steckel H., and Bolzen N. Alternative sugars as potential carriers for dry powder inhalations. International Journal of Pharmaceutics 270 1-2 (2004) 297-306
107. Steckel H., and Brandes H.G. A novel spray-drying technique to produce low density particles for pulmonary delivery. International Journal of Pharmaceutics 278 1 (2004) 187-195
108. Steckel H., Markefka P., teWierik H., and Kammelar R. Effect of milling and sieving on functionality of dry powder inhalation products. International Journal of Pharmaceutics 309 1-2 (2006) 51-59
109. Steckel H., Pichert L., and Muller B.W. Influence of process parameters in the ASES process on particle properties of budesonide for pulmonary delivery. European Journal of Pharmaceutics and Biopharmaceutics 57 3 (2004) 507-512
110. Steckel H., Thies J., and Muller B.W. Micronizing of steroids for pulmonary delivery by supercritical carbon dioxide. International Journal of Pharmaceutics 152 1 (1997) 99-110
111. Steeneken P.A.M., Woortman A.J.J., Gerritsen A.H., and Poort H. The influence of flow conditioners on some mechanical properties of potato starch powder. Powder Technology 47 (1986) 239-246
112. Tang P., Chan H.-K., Tam E., De Gruyter N., and Chan J. Preparation of NaCl powder suitable for inhalation. Industrial and Engineering Chemistry Research 45 12 (2006) 4188-4192
113. Taylor L.J., Papadopoulos D.G., Dunn P.J., Bentham A.C., Mitchell J.C., and Snowden M.J. Mechanical characterisation of powders using nanoindentation. Powder Technology 143-144 (2004) 179-185
114. Tee S.K., Marriott C., Zeng X.M., and Martin G.P. The use of different sugars as fine and coarse carriers for aerosolised salbutamol sulphate. International Journal of Pharmaceutics 208 1-2 (2000) 111-123
115. Telko M.J., Kujanpaa J., and Hickey A.J. Investigation of triboelectric charging in dry powder inhalers using electrical low pressure impactor (ELPI). International Journal of Pharmaceutics 336 2 (2007) 352-360
116. Tiddens H.A., Geller D.E., Challoner P., Speirs R.J., Kesser K.C., Overbeek S.E., et al. Effect of dry powder inhaler resistance on the inspiratory flow rates and volumes of cystic fibrosis patients of six years and older. Journal of Aerosol Medicine: The Official Journal of the International Society for Aerosols in Medicine 19 4 (2006) 456-465
117. Timsina M.P., Martin G.P., Marriott C., Ganderton D., and Yianneskis M. Drug-delivery to the respiratory-tract using dry powder inhalers. International Journal of Pharmaceutics 101 1-2 (1994) 1-13
118. Tobyn M., Staniforth J.N., Morton D., Harmer Q., and Newton M.E. Active and intelligent inhaler device development. International Journal of Pharmaceutics 277 1-2 (2004) 31-37
119. Tsuji, Y. (2007). Discrete particle simulation for optimization and validation of pharmaceutical powder processing (pp. 3-7). In The First Asian Symposium on Pharmaceutical Sciences and Technology.
120. Tsukada M., Irie R., Yonemochi Y., Noda R., Kamiya H., Watanabe W., et al. Adhesion force measurement of a DPI size pharmaceutical particle by colloid probe atomic force microscopy. Powder Technology 141 3 (2004) 262-269
121. Virchow J.C., Crompton G.K., Dal Negro R., Pedersen S., Magnan A., Seidenberg J., et al. Importance of inhaler devices in the management of airway disease. Respiratory Medicine 102 1 (2008) 10-19
122. Visser J. Van der waals and other cohesive forces affecting powder fluidization. Powder Technology 58 1 (1989) 1-10
123. Voss A., and Finlay W.H. Deagglomeration of dry powder pharmaceutical aerosols. International Journal of Pharmaceutics 248 1-2 (2002) 39-50
124. Wang Z., Lange C.F., and Finlay W.H. Use of an impinging jet for dispersion of dry powder inhalation aerosols. International Journal of Pharmaceutics 275 1-2 (2004) 123-131
125. Watano S., Pfeffer R., Dave R.N., and Dunphy W. Dry particle coating by a newly developed rotating fluidized bed coater. AIChE Symposium, Advanced Technology for Fluid-Particle System 321 95 (1999) 112-116
126. Werth J.H., Linsenbuhler M., Dammer S.M., Farkas Z., Hinrichsen H., Wirth K.E., et al. Agglomeration of charged nanopowders in suspensions. Powder Technology 133 1-3 (2003) 106-112
127. White S., Bennett D.B., Cheu S., Conley P.W., Guzek D.B., Gray S., et al. EXUBERA: Pharmaceutical development of a novel product for pulmonary delivery of insulin. Diabetes Technology & Therapeutics 7 6 (2005) 896-906
128. Xie H. The role of interparticle forces in the fluidization of fine particles. Powder Technology 94 2 (1997) 99-108
129. Yang J., Sliva A., Banerjee A., Dave R.N., and Pfeffer R. Dry particle coating for improving the flowability of cohesive powders. Powder Technology 158 1-3 (2005) 21-33
130. Yokoyama T., Urayama K., Naito M., Kato M., and Yokoyama T. The angmill mechanofusion system and its applications. KONA 5 5 (1987) 59-68
131. Young P.M., Cocconi D., Colombo P., Bettini R., Price R., Steele D.F., et al. Characterization of a surface modified dry powder inhalation carrier prepared by "particle smoothing". The Journal of Pharmacy and Pharmacology 54 10 (2002) 1339-1344
132. Young P.M., Thompson J., Woodcock D., Aydin M., and Price R. The development of a novel high-dose pressurized aerosol dry-powder device (PADD) for the delivery of pumactant for inhalation therapy. Journal of Aerosol Medicine-Deposition Clearance and Effects in the Lung 17 2 (2004) 123-128
133. Zeng X.M., Martin G.P., Marriott C., and Pritchard J. Crystallization of lactose from carbopol gels. Pharmaceutical Research 17 7 (2000) 879-886
134. Zeng X.M., Martin G.P., Marriott C., and Pritchard J. The effects of carrier size and morphology on the dispersion of salbutamol sulphate after aerosolization at different flow rates. Journal of Pharmacy and Pharmacology 52 10 (2000) 1211-1221
135. Zeng X.M., Martin G.P., Marriott C., and Pritchard J. The influence of carrier morphology on drug delivery by dry powder inhalers. International Journal of Pharmaceutics 200 1 (2000) 93-106
136. Zeng X.M., Martin G.P., Marriott C., and Pritchard J. Lactose as a carrier in dry powder formulations: The influence of surface characteristics on drug delivery. Journal of Pharmaceutical Sciences 90 9 (2001) 1424-1434
137. Zeng X.M., Martin G.P., Marriott C., and Pritchard J. The use of lactose recrystallised from carbopol gels as a carrier for aerosolised salbutamol sulphate. European Journal of Pharmaceutics and Biopharmaceutics 51 1 (2001) 55-62
138. Zeng X.M., Martin G.P., Tee S.K., and Marriott C. The role of fine particle lactose on the dispersion and deaggregation of salbutamol sulphate in an air stream in vitro. International Journal of Pharmaceutics 176 1 (1998) 99-110
139. Zeng X.M., Pandhal K.H., and Martin G.P. The influence of lactose carrier on the content homogeneity and dispersibility of beclomethasone dipropionate from dry powder aerosols. International Journal of Pharmaceutics 197 1-2 (2000) 41-52
140. Zhou T., and Li H. Effects of adding different size particles on fluidization of cohesive particles. Powder Technology 102 3 (1999) 215-220
141. Zhu, J., & Ma, Y. (2006). A new breath-activated, excipient-free dry powder inhaler and a rotating fluidized bed powder dispenser for pulmonary drug delivery: Vol. 3 (pp. 925-930). In Paper presented at the Respiratory Drug Delivery X. Boca Raton, Florida: Boca Raton Resort and Club.
142. Zhu, J., Wen, J., Ma, Y., & Zhang H. (2004). Apparatus for volumetric metering of small quantity of powder from fluidized beds. U.S. Patent 6,684,917.
143. Zhu, J., Wen, J., Ma, Y., & Zhang, H. (2006). Dry powder inhaler. US Patent Applications 11/399,616.
144. Zhu, J., & Zhang, H. (2004). Fluidization additives to fine powders. U.S. Patent 6,833,185.