Quality by design - Spray drying of insulin intended for inhalation

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 70, Issue 3, 2008, Pages 828-838

  Maltesen, Morten Jonas ^a,b   Bjerregaard, Simon ^b   Hovgaard, Lars ^b   Havelund, Svend ^b   van de Weert, Marco ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

Author keywords

Design of experiments; Inhalation; Insulin; Multivariate data analysis; Particle characteristics; Quality by design; Spray drying

Indexed keywords

HUMAN INSULIN;

ARTICLE; DENSITY; DRUG FORMULATION; DRUG MANUFACTURE; MOISTURE; MORPHOLOGY; PARTICLE SIZE; PRINCIPAL COMPONENT ANALYSIS; SPRAY DRYING;

ADMINISTRATION, INHALATION; AEROSOLS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DESICCATION; DRUG COMPOUNDING; HYPOGLYCEMIC AGENTS; INSULIN; PARTICLE SIZE; PRINCIPAL COMPONENT ANALYSIS; PROTEIN STABILITY; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE;

EID: 54949117110     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.07.015     Document Type: Article

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