The stability of insulin in solid formulations containing melezitose and starch. Effects of processing and excipients

Drug Development and Industrial Pharmacy

Volumn 32, Issue 6, 2006, Pages 765-778

  Mollmann, S H ^a   Bukrinsky, J T ^b   Elofsson, U ^c   Elversson, J ^c   Frokjaer, S ^a   Thalberg, K ^d   Millqvist Fureby, A ^c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c INSTITUTE FOR SURFACE CHEMISTRY   (Sweden)

^d ASTRAZENECA R AND D   (Sweden)

Author keywords

Chemical stability; Freeze drying; Insulin; Lyophilization; SEDS; Spray drying; Starch microspheres

Indexed keywords

EXCIPIENT; INSULIN; MICROSPHERE; STARCH; TAUROCHOLIC ACID; WATER;

ARTICLE; DISPERSION; DRUG FORMULARY; DRUG STABILITY; FREEZE DRYING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MORPHOLOGY; SOLID; SPRAY DRYING; STORAGE TEMPERATURE; SUPERCRITICAL FLUID; WATER TRANSPORT; X RAY DIFFRACTION;

CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG STABILITY; EXCIPIENTS; HYPOGLYCEMIC AGENTS; INSULIN; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; POWDERS; RECOMBINANT PROTEINS; STARCH; TAUROCHOLIC ACID; TECHNOLOGY, PHARMACEUTICAL; TRISACCHARIDES;

EID: 33746876037     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.1080/03639040600712458     Document Type: Article

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