The effect of process variables on the degradation and physical properties of spray dried insulin intended for inhalation

International Journal of Pharmaceutics

Volumn 233, Issue 1-2, 2002, Pages 227-237

  Ståhl, Kristina ^a   Claesson, Malin ^b   Lilliehorn, Pontus ^b   Lindén, Helena ^b   Bäckström, Kjell ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Degradation; Factorial design; Inhalation; Insulin; Moisture content; Particle size; Spray drying

Indexed keywords

RECOMBINANT HUMAN INSULIN; WATER;

AIR TEMPERATURE; ARTICLE; CONCENTRATION RESPONSE; DEVICE; DISSOLUTION; DRUG DEGRADATION; DRY POWDER; EXPERIMENTAL DESIGN; FLOW RATE; GAS FLOW; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INHALATION; INSULIN DEGRADATION; LASER DIFFRACTION; MOISTURE; MOLECULAR WEIGHT; PARAMETER; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROCESS CONTROL; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; STATISTICAL PARAMETERS; THERMOGRAVIMETRY; WEIGHT;

ADMINISTRATION, INHALATION; AEROSOLS; CHEMISTRY, PHARMACEUTICAL; DRUG EVALUATION, PRECLINICAL; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MOLECULAR WEIGHT; PARTICLE SIZE; POWDERS; PROTEINS; TEMPERATURE;

EID: 0037148657     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00945-0     Document Type: Article

References (16)

1. The spray drying of pharmaceuticals
2. The effect of process and formulation variables on the properties of spray dried β-galactosidase
3. The destruction of enzymes and bacteria during the spray drying of milk and whey. 2. The effect of the drying conditions
4. Spray-drying as a preparation method of microparticulate drug delivery systems: An overview
5. The preparation of recombinant human deoxyribonuclease powder: Comparative studies of spray drying versus lyophilization and application of microwave drying
6. Protective effect of sucrose on spray drying of oxyhemoglobin
7. The effect of operating and formulation variables on the morphology of spray-dried protein particles
8. Applications in the pharmaceutical-biochemical industry
9. Nozzle atomization
10. Feasibility study on spray-drying protein pharmaceuticals: Recombinant human growth hormone and tissue-type plasminogen activator
11. Formulation and physical characterization of large porous particles for inhalation
12. Comparison of physical and inhalation properties of spray dried and mechanically micronized disodium cromoglycate