Effect of spray drying and subsequent processing conditions on residual moisture content and physical/biochemical stability of protein inhalation powders

Pharmaceutical Research

Volumn 15, Issue 5, 1998, Pages 768-775

  Maa, Yuh Fun ^a   Nguyen, Phuong Anh ^a   Andya, James D ^a   Dasovich, Nancy ^a   Sweeney, Theresa D ^a   Shire, Steven J ^a   Hsu, Chung C ^a  

^a GENENTECH INC   (United States)

Author keywords

Equilibrium moisture content; Gravimetric moisture sorption isotherm; Protein aggregation; Relative humidity; Residual moisture; Spray drying

Indexed keywords

DEOXYRIBONUCLEASE; MANNITOL; MONOCLONAL ANTIBODY; TREHALOSE;

ARTICLE; DRUG STABILITY; DRUG STORAGE; DRY POWDER; GOOD MANUFACTURING PRACTICE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMIDITY; MOISTURE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN STABILITY; WATER CONTENT;

ADMINISTRATION, INHALATION; AEROSOLS; ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYRIBONUCLEASES; DRUG STABILITY; HUMIDITY; PARTICLE SIZE; POWDERS; VACUUM;

EID: 0031780284     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011983322594     Document Type: Article

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