Neurodegenerative mechanisms in Alzheimer disease: A role for oxidative damage in amyloid β protein precursor-mediated cell death

Molecular and Chemical Neuropathology

Volumn 29, Issue 2-3, 1996, Pages 153-168

  Sopher, Bryce L ^a   Fukuchi, Ken Ichiro ^a   Kavanagh, Terrance J ^a   Furlong, Clement E ^b   Martin, George M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer disease; amyloid protein precursor; Neurodegeneration

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ANTIOXIDANT; HYBRID PROTEIN; REACTIVE OXYGEN METABOLITE;

AGING; ALZHEIMER DISEASE; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; NERVE CELL NECROSIS; NERVE DEGENERATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DOMAIN;

EID: 0030475452     PISSN: 10447393     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02814999     Document Type: Article

References (10)

1. Ames B. N., Shigenaga M. K., and Hagen T. M. (1993) Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. USA 90, 7915-7922.
2. Andorn A. C., Britton R. S., and Bacon B. R. (1990) Evidence that lipid peroxidation and total iron are increased in Alzheimer's brain. Neurobiol. Aging 11, 316-321.
3. Behl C., Davis J. B., Lesley R., and Schubert D. (1994) Hydrogen peroxide mediates amyloid β protein toxicity. Cell 77, 817-827.
4. Carney J. M., Starke-Reed P. E., Oliver C. N., Landum R. W., Cheng M. S., Wu J. F., and Floyd R. A. (1991) Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spacial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone. Proc. Natl. Acad. Sci. USA 88, 3633-3636.
5. Citron M., Oltersdorf T., Haass C., McConlogue L., Hung A. Y., Seubert P., Vigo-Pelfrey C., Lieberburg I., and Selkoe D. J. (1992) Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature 360, 672-674.
6. Eaton D. L. and Hamel D. M. (1994) Increase in γ-glutamylcysteine synthetase activity as a mechanism for butylated hydroxyanisole-mediated elevation of hepatic glutathione. Toxicol. Appl. Pharmacol. 126, 145-149.
7. Fukuchi K., Kamino K., Deeb S. S., Smith A. C., Dang T., and Martin G. M. (1992) Overexpression of amyloid precursor protein alters its normal processing and is associated with neurotoxicity. Biochem. Biophys. Res. Commun. 182, 165-173.
8. Fukuchi K., Sopher B., Furlong C. E., Smith A. C., Dang T., and Martin G. M. (1993a) Selective neurotoxicity of COOH-terminal fragments of the beta-amyloid precursor protein. Neurosci. Lett. 154, 145-148.
9. Fukuchi K., Sopher B., and Martin G. M. (1993b) Neurotoxicity of beta-amyloid. Nature 361, 122-123.
10. Fukuchi K., Ogburn C. E., Smith A. C., Kunkel D. D., Furlong C. E., Deeb S. S., Nochlin D., Sumi S. M., and Martin G. M. (1993c) Transgenic animal models for Alzheimer's disease. Ann. NY Acad. Sci. 695, 217-223.