Overexpression of p62/SQSTM1 promotes the degradations of abnormally accumulated PrP mutants in cytoplasm and relieves the associated cytotoxicities via autophagy-lysosome-dependent way

Medical Microbiology and Immunology

Volumn 203, Issue 2, 2014, Pages 73-84

  Xu, Yin ^a   Zhang, Jin ^a,c   Tian, Chan ^a   Ren, Ke ^a   Yan, Yu E ^a   Wang, Ke ^a   Wang, Hui ^a   Chen, Cao ^a   Wang, Jing ^a   Shi, Qi ^a   Dong, Xiao Ping ^a,b  

^a National Institute for Viral Disease Control and Prevention   (China)

^b INSTITUTE OF MICROBIOLOGY   (China)

^c Shandong Entry Exit Inspection and Quarantine Bureau   (China)

Author keywords

Autophagy; p62 SQSTM1; PrP CYTO; PrP PG14

Indexed keywords

PRION PROTEIN; PROTEASOME INHIBITOR; PROTEIN P62; PRION; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SQSTM1 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL AGGREGATION; CELL INCLUSION; CELL STRAIN HEK293; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; LYSOSOME; MUTANT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; WESTERN BLOTTING; BIOSYNTHESIS; CELL LINE; GENETICS; HEK293 CELL LINE; METABOLISM; MUTATION; PHYSIOLOGY; PRION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS; AUTOPHAGY; CELL LINE; CYTOPLASM; HEK293 CELLS; HUMANS; INCLUSION BODIES; LYSOSOMES; MUTATION; PRIONS;

EID: 84898059602     PISSN: 03008584     EISSN: 14321831     Source Type: Journal    
DOI: 10.1007/s00430-013-0316-z     Document Type: Article

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