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Volumn 8, Issue 11, 2012, Pages 1604-1620

Activation of the macroautophagic system in scrapie-infected experimental animals and human genetic prion diseases

Author keywords

Autophagy; Neurodegenerative diseases; Transmissible spongiform encephalopathies

Indexed keywords

BAFILOMYCIN A1; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN 1; PRION PROTEIN; SEQUESTOSOME 1; UBIQUITINATED PROTEIN; UNCLASSIFIED DRUG;

EID: 84869475871     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.21482     Document Type: Article
Times cited : (49)

References (55)
  • 1
    • 0037264120 scopus 로고    scopus 로고
    • Unfolding the role of protein misfolding in neurodegenerative diseases
    • PMID:12511861
    • Soto C. Unfolding the role of protein misfolding in neurodegenerative diseases. Nat Rev Neurosci 2003; 4:49-60; PMID:12511861; http://dx.doi.org/10. 1038/nrn1007
    • (2003) Nat Rev Neurosci , vol.4 , pp. 49-60
    • Soto, C.1
  • 2
    • 33750363298 scopus 로고    scopus 로고
    • The roles of intracellular proteindegradation pathways in neurodegeneration
    • PMID:17051204
    • Rubinsztein DC. The roles of intracellular proteindegradation pathways in neurodegeneration. Nature 2006; 443:780-6; PMID:17051204; http://dx.doi.org/10. 1038/nature05291
    • (2006) Nature , vol.443 , pp. 780-786
    • Rubinsztein, D.C.1
  • 3
    • 37649024076 scopus 로고    scopus 로고
    • Small molecule regulators of autophagy identified by an image-based high-throughput screen
    • PMID:18024584
    • Zhang L, Yu J, Pan H, Hu P, Hao Y, Cai W, et al. Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci U S A 2007; 104:19023-8; PMID:18024584; http://dx.doi.org/10. 1073/pnas.0709695104
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 19023-19028
    • Zhang, L.1    Yu, J.2    Pan, H.3    Hu, P.4    Hao, Y.5    Cai, W.6
  • 4
    • 0037401773 scopus 로고    scopus 로고
    • Role of proteasomes in the degradation of short-lived proteins in human fibroblasts under various growth conditions
    • PMID:12672457
    • Fuertes G, Villarroya A, Knecht E. Role of proteasomes in the degradation of short-lived proteins in human fibroblasts under various growth conditions. Int J Biochem Cell Biol 2003; 35:651-64; PMID:12672457; http://dx.doi.org/10. 1016/S1357-2725(02)00382-5
    • (2003) Int J Biochem Cell Biol , vol.35 , pp. 651-664
    • Fuertes, G.1    Villarroya, A.2    Knecht, E.3
  • 5
    • 2642586352 scopus 로고    scopus 로고
    • Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
    • PMID:15146184
    • Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, et al. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet 2004; 36:585-95; PMID:15146184; http://dx.doi.org/10.1038/ng1362
    • (2004) Nat Genet , vol.36 , pp. 585-595
    • Ravikumar, B.1    Vacher, C.2    Berger, Z.3    Davies, J.E.4    Luo, S.5    Oroz, L.G.6
  • 6
    • 0347986620 scopus 로고    scopus 로고
    • Class III phosphoinositide 3-kinase - Beclin1 complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes
    • PMID:12967324
    • Tassa A, Roux MP, Attaix D, Bechet DM. Class III phosphoinositide 3-kinase - Beclin1 complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes. Biochem J 2003; 376:577-86; PMID:12967324; http://dx.doi.org/10.1042/BJ20030826
    • (2003) Biochem J , vol.376 , pp. 577-586
    • Tassa, A.1    Roux, M.P.2    Attaix, D.3    Bechet, D.M.4
  • 7
    • 79961107211 scopus 로고    scopus 로고
    • Silencing of cellular prion protein (PrPC) expression by DNA-antisense oligonucleotides induces autophagy-dependent cell death in glioma cells
    • PMID:21478678
    • Barbieri G, Palumbo S, Gabrusiewicz K, Azzalin A, Marchesi N, Spedito A, et al. Silencing of cellular prion protein (PrPC) expression by DNA-antisense oligonucleotides induces autophagy-dependent cell death in glioma cells. Autophagy 2011; 7:840-53; PMID:21478678; http://dx.doi.org/10.4161/auto.7.8. 15615
    • (2011) Autophagy , vol.7 , pp. 840-853
    • Barbieri, G.1    Palumbo, S.2    Gabrusiewicz, K.3    Azzalin, A.4    Marchesi, N.5    Spedito, A.6
  • 8
    • 45749114895 scopus 로고    scopus 로고
    • The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice
    • PMID:18497889
    • Pickford F, Masliah E, Britschgi M, Lucin K, Narasimhan R, Jaeger PA, et al. The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest 2008; 118:2190-9; PMID:18497889
    • (2008) J Clin Invest , vol.118 , pp. 2190-2199
    • Pickford, F.1    Masliah, E.2    Britschgi, M.3    Lucin, K.4    Narasimhan, R.5    Jaeger, P.A.6
  • 9
    • 77951665859 scopus 로고    scopus 로고
    • Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
    • PMID:20383138
    • Martinez-Vicente M, Talloczy Z, Wong E, Tang G, Koga H, Kaushik S, et al. Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease. Nat Neurosci 2010; 13:567-76; PMID:20383138; http://dx.doi.org/10.1038/nn.2528
    • (2010) Nat Neurosci , vol.13 , pp. 567-576
    • Martinez-Vicente, M.1    Talloczy, Z.2    Wong, E.3    Tang, G.4    Koga, H.5    Kaushik, S.6
  • 10
    • 33745192802 scopus 로고    scopus 로고
    • Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
    • PMID:16625204
    • Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006; 441:885- 9; PMID:16625204; http://dx.doi.org/10. 1038/nature04724
    • (2006) Nature , vol.441 , pp. 885-889
    • Hara, T.1    Nakamura, K.2    Matsui, M.3    Yamamoto, A.4    Nakahara, Y.5    Suzuki-Migishima, R.6
  • 11
    • 33646800306 scopus 로고    scopus 로고
    • Loss of autophagy in the central nervous system causes neurodegeneration in mice
    • PMID:16625205
    • Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006; 441:880-4; PMID:16625205; http://dx.doi.org/10.1038/nature04723
    • (2006) Nature , vol.441 , pp. 880-884
    • Komatsu, M.1    Waguri, S.2    Chiba, T.3    Murata, S.4    Iwata, J.5    Tanida, I.6
  • 12
    • 0025744499 scopus 로고
    • Neuronal autophagy in experimental scrapie
    • PMID:1927279
    • Boellaard JW, Kao M, Schlote W, Diringer H. Neuronal autophagy in experimental scrapie. Acta Neuropathol 1991; 82:225-8; PMID:1927279; http://dx.doi.org/10.1007/BF00294449
    • (1991) Acta Neuropathol , vol.82 , pp. 225-228
    • Boellaard, J.W.1    Kao, M.2    Schlote, W.3    Diringer, H.4
  • 13
    • 4344656905 scopus 로고    scopus 로고
    • Autophagy is a part of ultrastructural synaptic pathology in Creutzfeldt-Jakob disease: A brain biopsy study
    • PMID:15325593
    • Sikorska B, Liberski PP, Giraud P, Kopp N, Brown P. Autophagy is a part of ultrastructural synaptic pathology in Creutzfeldt-Jakob disease: a brain biopsy study. Int J Biochem Cell Biol 2004; 36:2563-73; PMID:15325593; http://dx.doi.org/10.1016/j.biocel.2004.04.014
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 2563-2573
    • Sikorska, B.1    Liberski, P.P.2    Giraud, P.3    Kopp, N.4    Brown, P.5
  • 14
    • 2442462295 scopus 로고    scopus 로고
    • Comparison study on clinical and neuropathological characteristics of hamsters inoculated with scrapie strain 263K in different challenging pathways
    • PMID:15202866
    • Zhang J, Chen L, Zhang BY, Han J, Xiao XL, Tian HY, et al. Comparison study on clinical and neuropathological characteristics of hamsters inoculated with scrapie strain 263K in different challenging pathways. Biomed Environ Sci 2004; 17:65-78; PMID:15202866
    • (2004) Biomed Environ Sci , vol.17 , pp. 65-78
    • Zhang, J.1    Chen, L.2    Zhang, B.Y.3    Han, J.4    Xiao, X.L.5    Tian, H.Y.6
  • 15
    • 2442443113 scopus 로고    scopus 로고
    • Dynamic analyses of PrP and PrP(Sc) in brain tissues of golden hamsters infected with scrapie strain 263K revealed various PrP forms
    • PMID:15202859
    • Gao JM, Gao C, Han J, Zhou XB, Xiao XL, Zhang J, et al. Dynamic analyses of PrP and PrP(Sc) in brain tissues of golden hamsters infected with scrapie strain 263K revealed various PrP forms. Biomed Environ Sci 2004; 17:8-20; PMID:15202859
    • (2004) Biomed Environ Sci , vol.17 , pp. 8-20
    • Gao, J.M.1    Gao, C.2    Han, J.3    Zhou, X.B.4    Xiao, X.L.5    Zhang, J.6
  • 16
    • 84855940097 scopus 로고    scopus 로고
    • The diversities of PrP(Sc) distributions and pathologic changes in various brain regions from a Chinese patient with G114V genetic CJD
    • PMID:21732990
    • Shi Q, Zhang BY, Gao C, Han J, Wang GR, Chen C, et al. The diversities of PrP(Sc) distributions and pathologic changes in various brain regions from a Chinese patient with G114V genetic CJD. Neuropathology 2012; 32:51-9; PMID:21732990; http://dx.doi.org/10.1111/j.1440-1789.2011.01237.x
    • (2012) Neuropathology , vol.32 , pp. 51-59
    • Shi, Q.1    Zhang, B.Y.2    Gao, C.3    Han, J.4    Wang, G.R.5    Chen, C.6
  • 17
    • 27944504351 scopus 로고    scopus 로고
    • P62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    • PMID:16286508
    • Bjørkøy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 2005; 171:603-14; PMID:16286508; http://dx.doi.org/10.1083/jcb.200507002
    • (2005) J Cell Biol , vol.171 , pp. 603-614
    • Bjørkøy, G.1    Lamark, T.2    Brech, A.3    Outzen, H.4    Perander, M.5    Overvatn, A.6
  • 18
    • 84855822399 scopus 로고    scopus 로고
    • Remarkable reduction of MAP2 in the brains of scrapie-infected rodents and human prion disease possibly correlated with the increase of calpain
    • PMID:22272295
    • Guo Y, Gong HS, Zhang J, Xie WL, Tian C, Chen C, et al. Remarkable reduction of MAP2 in the brains of scrapie-infected rodents and human prion disease possibly correlated with the increase of calpain. PLoS One 2012; 7:e30163; PMID:22272295; http://dx.doi.org/10.1371/journal.pone.0030163
    • (2012) PLoS One , vol.7
    • Guo, Y.1    Gong, H.S.2    Zhang, J.3    Xie, W.L.4    Tian, C.5    Chen, C.6
  • 19
    • 80054905533 scopus 로고    scopus 로고
    • A novel PrP partner HS-1 associated protein X-1 (HAX-1) protected the cultured cells against the challenge of H2O2
    • PMID:21301993
    • Jing YY, Li XL, Shi Q, Wang ZY, Guo Y, Pan MM, et al. A novel PrP partner HS-1 associated protein X-1 (HAX-1) protected the cultured cells against the challenge of H2O2. J Mol Neurosci 2011; 45:216-28; PMID:21301993; http://dx.doi.org/10.1007/s12031-011-9498-2
    • (2011) J Mol Neurosci , vol.45 , pp. 216-228
    • Jing, Y.Y.1    Li, X.L.2    Shi, Q.3    Wang, Z.Y.4    Guo, Y.5    Pan, M.M.6
  • 20
    • 26444515364 scopus 로고    scopus 로고
    • Autophagy and its possible roles in nervous system diseases, damage and repair
    • PMID:16874045
    • Rubinsztein DC, DiFiglia M, Heintz N, Nixon RA, Qin ZH, Ravikumar B, et al. Autophagy and its possible roles in nervous system diseases, damage and repair. Autophagy 2005; 1:11-22; PMID:16874045; http://dx.doi.org/10.4161/auto. 1.1.1513
    • (2005) Autophagy , vol.1 , pp. 11-22
    • Rubinsztein, D.C.1    DiFiglia, M.2    Heintz, N.3    Nixon, R.A.4    Qin, Z.H.5    Ravikumar, B.6
  • 21
  • 22
    • 33751034682 scopus 로고    scopus 로고
    • Aggregate-prone proteins are cleared from the cytosol by autophagy: Therapeutic implications
    • PMID:17118264
    • Williams A, Jahreiss L, Sarkar S, Saiki S, Menzies FM, Ravikumar B, et al. Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications. Curr Top Dev Biol 2006; 76:89-101; PMID:17118264; http://dx.doi.org/10.1016/S0070-2153(06)76003-3
    • (2006) Curr Top Dev Biol , vol.76 , pp. 89-101
    • Williams, A.1    Jahreiss, L.2    Sarkar, S.3    Saiki, S.4    Menzies, F.M.5    Ravikumar, B.6
  • 23
    • 34247185404 scopus 로고    scopus 로고
    • Disease-associated prion protein oligomers inhibit the 26S proteasome
    • PMID:17466621
    • Kristiansen M, Deriziotis P, Dimcheff DE, Jackson GS, Ovaa H, Naumann H, et al. Disease-associated prion protein oligomers inhibit the 26S proteasome. Mol Cell 2007; 26:175-88; PMID:17466621; http://dx.doi.org/10.1016/j.molcel. 2007.04.001
    • (2007) Mol Cell , vol.26 , pp. 175-188
    • Kristiansen, M.1    Deriziotis, P.2    Dimcheff, D.E.3    Jackson, G.S.4    Ovaa, H.5    Naumann, H.6
  • 24
    • 61849102412 scopus 로고    scopus 로고
    • Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy
    • PMID:19183256
    • Heiseke A, Aguib Y, Riemer C, Baier M, Schätzl HM. Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy. J Neurochem 2009; 109:25-34; PMID:19183256; http://dx.doi.org/10.1111/j.1471-4159.2009.05906.x
    • (2009) J Neurochem , vol.109 , pp. 25-34
    • Heiseke, A.1    Aguib, Y.2    Riemer, C.3    Baier, M.4    Schätzl, H.M.5
  • 25
    • 65249103439 scopus 로고    scopus 로고
    • Autophagy induction by trehalose counteracts cellular prion infection
    • PMID:19182537
    • Aguib Y, Heiseke A, Gilch S, Riemer C, Baier M, Schätzl HM, et al. Autophagy induction by trehalose counteracts cellular prion infection. Autophagy 2009; 5:361-9; PMID:19182537; http://dx.doi.org/10.4161/auto.5.3.7662
    • (2009) Autophagy , vol.5 , pp. 361-369
    • Aguib, Y.1    Heiseke, A.2    Gilch, S.3    Riemer, C.4    Baier, M.5    Schätzl, H.M.6
  • 26
    • 4744361580 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor STI571 induces cellular clearance of PrPSc in prion-infected cells
    • PMID:15247213
    • Ertmer A, Gilch S, Yun SW, Flechsig E, Klebl B, Stein-Gerlach M, et al. The tyrosine kinase inhibitor STI571 induces cellular clearance of PrPSc in prion-infected cells. J Biol Chem 2004; 279:41918-27; PMID:15247213; http://dx.doi.org/10.1074/jbc.M405652200
    • (2004) J Biol Chem , vol.279 , pp. 41918-41927
    • Ertmer, A.1    Gilch, S.2    Yun, S.W.3    Flechsig, E.4    Klebl, B.5    Stein-Gerlach, M.6
  • 27
    • 71549115512 scopus 로고    scopus 로고
    • Autophagy and cell death of Purkinje cells overexpressing Doppel in Ngsk Prnp-deficient mice
    • PMID:19055638
    • Heitz S, Grant NJ, Leschiera R, Haeberlé AM, Demais V, Bombarde G, et al. Autophagy and cell death of Purkinje cells overexpressing Doppel in Ngsk Prnp-deficient mice. Brain Pathol 2010; 20:119-32; PMID:19055638; http://dx.doi.org/10.1111/j.1750-3639.2008.00245.x
    • (2010) Brain Pathol , vol.20 , pp. 119-132
    • Heitz, S.1    Grant, N.J.2    Leschiera, R.3    Haeberlé, A.M.4    Demais, V.5    Bombarde, G.6
  • 28
    • 65249124680 scopus 로고    scopus 로고
    • Doppel induces autophagic stress in prion protein-deficient Purkinje cells
    • PMID:19320049
    • Heitz S, Grant NJ, Bailly Y. Doppel induces autophagic stress in prion protein-deficient Purkinje cells. Autophagy 2009; 5:422-4; PMID:19320049; http://dx.doi.org/10.4161/auto.5.3.7882
    • (2009) Autophagy , vol.5 , pp. 422-424
    • Heitz, S.1    Grant, N.J.2    Bailly, Y.3
  • 29
    • 77953913051 scopus 로고    scopus 로고
    • Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
    • PMID:20541250
    • Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, et al. Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell 2010; 141:1146-58; PMID:20541250; http://dx.doi.org/10.1016/j.cell.2010.05.008
    • (2010) Cell , vol.141 , pp. 1146-1158
    • Lee, J.H.1    Yu, W.H.2    Kumar, A.3    Lee, S.4    Mohan, P.S.5    Peterhoff, C.M.6
  • 30
    • 2942566227 scopus 로고    scopus 로고
    • Microtubule disruption inhibits autophagosome-lysosome fusion: Implications for studying the roles of aggresomes in polyglutamine diseases
    • PMID:15325591
    • Webb JL, Ravikumar B, Rubinsztein DC. Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases. Int J Biochem Cell Biol 2004; 36:2541-50; PMID:15325591; http://dx.doi.org/10.1016/j.biocel.2004.02.003
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 2541-2550
    • Webb, J.L.1    Ravikumar, B.2    Rubinsztein, D.C.3
  • 31
    • 77954116814 scopus 로고    scopus 로고
    • Autophagy gone awry in neurodegenerative diseases
    • PMID:20581817
    • Wong E, Cuervo AM. Autophagy gone awry in neurodegenerative diseases. Nat Neurosci 2010; 13:805-11; PMID:20581817; http://dx.doi.org/10.1038/nn.2575
    • (2010) Nat Neurosci , vol.13 , pp. 805-811
    • Wong, E.1    Cuervo, A.M.2
  • 33
    • 0023793690 scopus 로고
    • Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases
    • PMID:2837768
    • Manetto V, Perry G, Tabaton M, Mulvihill P, Fried VA, Smith HT, et al. Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases. Proc Natl Acad Sci U S A 1988; 85:4501-5; PMID:2837768; http://dx.doi.org/10.1073/pnas.85.12.4501
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 4501-4505
    • Manetto, V.1    Perry, G.2    Tabaton, M.3    Mulvihill, P.4    Fried, V.A.5    Smith, H.T.6
  • 34
    • 68349097450 scopus 로고    scopus 로고
    • P62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis
    • PMID:19557423
    • Nogalska A, Terracciano C, D'Agostino C, King Engel W, Askanas V. p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis. Acta Neuropathol 2009; 118:407-13;PMID:19557423; http://dx.doi.org/10.1007/s00401-009-0564-6
    • (2009) Acta Neuropathol , vol.118 , pp. 407-413
    • Nogalska, A.1    Terracciano, C.2    D'Agostino, C.3    King Engel, W.4    Askanas, V.5
  • 35
    • 33746805387 scopus 로고    scopus 로고
    • Signaling, polyubiquitination, trafficking, and inclusions: Sequestosome 1/p62's role in neurodegenerative disease
    • PMID:17047309
    • Wooten MW, Hu X, Babu JR, Seibenhener ML, Geetha T, Paine MG, et al. Signaling, polyubiquitination, trafficking, and inclusions: sequestosome 1/p62's role in neurodegenerative disease. J Biomed Biotechnol 2006; 2006:62079; PMID:17047309; http://dx.doi.org/10.1155/JBB/2006/62079
    • (2006) J Biomed Biotechnol , vol.2006 , pp. 62079
    • Wooten, M.W.1    Hu, X.2    Babu, J.R.3    Seibenhener, M.L.4    Geetha, T.5    Paine, M.G.6
  • 36
    • 1942531594 scopus 로고    scopus 로고
    • Prion protein is ubiquitinated after developing protease resistance in the brains of scrapie-infected mice
    • PMID:15095484
    • Kang SC, Brown DR, Whiteman M, Li R, Pan T, Perry G, et al. Prion protein is ubiquitinated after developing protease resistance in the brains of scrapie-infected mice. J Pathol 2004; 203:603-8; PMID:15095484; http://dx.doi.org/10.1002/path.1555
    • (2004) J Pathol , vol.203 , pp. 603-608
    • Kang, S.C.1    Brown, D.R.2    Whiteman, M.3    Li, R.4    Pan, T.5    Perry, G.6
  • 37
    • 77950501014 scopus 로고    scopus 로고
    • MTOR regulation of autophagy
    • PMID:20083114
    • Jung CH, Ro SH, Cao J, Otto NM, Kim DH. mTOR regulation of autophagy. FEBS Lett 2010; 584:1287-95; PMID:20083114; http://dx.doi.org/10.1016/j.febslet. 2010.01.017
    • (2010) FEBS Lett , vol.584 , pp. 1287-1295
    • Jung, C.H.1    Ro, S.H.2    Cao, J.3    Otto, N.M.4    Kim, D.H.5
  • 38
    • 58149463424 scopus 로고    scopus 로고
    • MTOR-dependent signalling in Alzheimer's disease
    • PMID:19210753
    • Pei JJ, Hugon J. mTOR-dependent signalling in Alzheimer's disease. J Cell Mol Med 2008; 12(6B):2525-32; PMID:19210753; http://dx.doi.org/10.1111/j.1582- 4934.2008.00509.x
    • (2008) J Cell Mol Med , vol.12 , Issue.6 B , pp. 2525-2532
    • Pei, J.J.1    Hugon, J.2
  • 39
    • 77956305343 scopus 로고    scopus 로고
    • Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease
    • PMID:20376313
    • Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, et al. Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One 2010; 5:e9979; PMID:20376313; http://dx.doi.org/10.1371/journal.pone.0009979
    • (2010) PLoS One , vol.5
    • Spilman, P.1    Podlutskaya, N.2    Hart, M.J.3    Debnath, J.4    Gorostiza, O.5    Bredesen, D.6
  • 40
    • 75749127850 scopus 로고    scopus 로고
    • Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease
    • PMID:20089925
    • Malagelada C, Jin ZH, Jackson-Lewis V, Przedborski S, Greene LA. Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease. J Neurosci 2010; 30:1166-75; PMID:20089925; http://dx.doi.org/10.1523/JNEUROSCI.3944-09.2010
    • (2010) J Neurosci , vol.30 , pp. 1166-1175
    • Malagelada, C.1    Jin, Z.H.2    Jackson-Lewis, V.3    Przedborski, S.4    Greene, L.A.5
  • 41
    • 0041589248 scopus 로고    scopus 로고
    • Alpha-Synuclein is degraded by both autophagy and the proteasome
    • PMID:12719433
    • Webb JL, Ravikumar B, Atkins J, Skepper JN, Rubinsztein DC. Alpha-Synuclein is degraded by both autophagy and the proteasome. J Biol Chem 2003; 278:25009-13; PMID:12719433; http://dx.doi.org/10.1074/jbc.M300227200
    • (2003) J Biol Chem , vol.278 , pp. 25009-25013
    • Webb, J.L.1    Ravikumar, B.2    Atkins, J.3    Skepper, J.N.4    Rubinsztein, D.C.5
  • 42
    • 74249103961 scopus 로고    scopus 로고
    • Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3
    • PMID:20007218
    • Menzies FM, Huebener J, Renna M, Bonin M, Riess O, Rubinsztein DC. Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3. Brain 2010; 133:93-104; PMID:20007218; http://dx.doi.org/10.1093/brain/awp292
    • (2010) Brain , vol.133 , pp. 93-104
    • Menzies, F.M.1    Huebener, J.2    Renna, M.3    Bonin, M.4    Riess, O.5    Rubinsztein, D.C.6
  • 43
    • 31544454404 scopus 로고    scopus 로고
    • Rapamycin alleviates toxicity of different aggregate-prone proteins
    • PMID:16368705
    • Berger Z, Ravikumar B, Menzies FM, Oroz LG, Underwood BR, Pangalos MN, et al. Rapamycin alleviates toxicity of different aggregate-prone proteins. Hum Mol Genet 2006; 15:433-42; PMID:16368705; http://dx.doi.org/10.1093/hmg/ddi458
    • (2006) Hum Mol Genet , vol.15 , pp. 433-442
    • Berger, Z.1    Ravikumar, B.2    Menzies, F.M.3    Oroz, L.G.4    Underwood, B.R.5    Pangalos, M.N.6
  • 44
    • 79952628267 scopus 로고    scopus 로고
    • The Beclin 1 network regulates autophagy and apoptosis
    • PMID:21311563
    • Kang R, Zeh HJ, Lotze MT, Tang D. The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ 2011; 18:571-80; PMID:21311563; http://dx.doi.org/10.1038/cdd.2010.191
    • (2011) Cell Death Differ , vol.18 , pp. 571-580
    • Kang, R.1    Zeh, H.J.2    Lotze, M.T.3    Tang, D.4
  • 46
    • 0034608663 scopus 로고    scopus 로고
    • Differential expression of Bax and Bcl-2 in the brains of hamsters infected with 263K scrapie agent
    • PMID:10852224
    • Park SK, Choi SI, Jin JK, Choi EK, Kim JI, Carp RI, et al. Differential expression of Bax and Bcl-2 in the brains of hamsters infected with 263K scrapie agent. Neuroreport 2000; 11:1677-82; PMID:10852224; http://dx.doi.org/10.1097/ 00001756-200006050-00017
    • (2000) Neuroreport , vol.11 , pp. 1677-1682
    • Park, S.K.1    Choi, S.I.2    Jin, J.K.3    Choi, E.K.4    Kim, J.I.5    Carp, R.I.6
  • 47
    • 69449095508 scopus 로고    scopus 로고
    • Cytosolic prion protein induces apoptosis in human neuronal cell SH-SY5Y via mitochondrial disruption pathway
    • PMID:19643043
    • Wang X, Dong CF, Shi Q, Shi S, Wang GR, Lei YJ, et al. Cytosolic prion protein induces apoptosis in human neuronal cell SH-SY5Y via mitochondrial disruption pathway. BMB Rep 2009; 42:444-9; PMID:19643043; http://dx.doi.org/10. 5483/BMBRep.2009.42.7.444
    • (2009) BMB Rep , vol.42 , pp. 444-449
    • Wang, X.1    Dong, C.F.2    Shi, Q.3    Shi, S.4    Wang, G.R.5    Lei, Y.J.6
  • 48
    • 79954424574 scopus 로고    scopus 로고
    • Human prion protein mutants with deleted and inserted octarepeats undergo different pathways to trigger cell apoptosis
    • PMID:20526696
    • Xu K, Wang X, Shi Q, Chen C, Tian C, Li XL, et al. Human prion protein mutants with deleted and inserted octarepeats undergo different pathways to trigger cell apoptosis. J Mol Neurosci 2011; 43:225-34; PMID:20526696; http://dx.doi.org/10.1007/s12031-010-9387-0
    • (2011) J Mol Neurosci , vol.43 , pp. 225-234
    • Xu, K.1    Wang, X.2    Shi, Q.3    Chen, C.4    Tian, C.5    Li, X.L.6
  • 49
    • 65549099222 scopus 로고    scopus 로고
    • All-you-can-eat: Autophagy in neurodegeneration and neuroprotection
    • PMID:19348680
    • Jaeger PA, Wyss-Coray T. All-you-can-eat: autophagy in neurodegeneration and neuroprotection. Mol Neurodegener 2009; 4:16; PMID:19348680; http://dx.doi.org/10.1186/1750-1326-4-16
    • (2009) Mol Neurodegener , vol.4 , pp. 16
    • Jaeger, P.A.1    Wyss-Coray, T.2
  • 50
    • 57649195400 scopus 로고    scopus 로고
    • Autophagy and multivesicular bodies: Two closely related partners
    • PMID:19008921
    • Fader CM, Colombo MI. Autophagy and multivesicular bodies: two closely related partners. Cell Death Differ 2009; 16:70-8; PMID:19008921; http://dx.doi.org/10.1038/cdd.2008.168
    • (2009) Cell Death Differ , vol.16 , pp. 70-78
    • Fader, C.M.1    Colombo, M.I.2
  • 51
    • 66349120877 scopus 로고    scopus 로고
    • Autophagy protects neuron from Abeta-induced cytotoxicity
    • PMID:19270530
    • Hung SY, Huang WP, Liou HC, Fu WM. Autophagy protects neuron from Abeta-induced cytotoxicity. Autophagy 2009; 5:502-10; PMID:19270530; http://dx.doi.org/10.4161/auto.5.4.8096
    • (2009) Autophagy , vol.5 , pp. 502-510
    • Hung, S.Y.1    Huang, W.P.2    Liou, H.C.3    Fu, W.M.4
  • 52
    • 0026605853 scopus 로고
    • Lysosomes as key organelles in the pathogenesis of prion encephalopathies
    • PMID:1355530
    • Laszlo L, Lowe J, Self T, Kenward N, Landon M, McBride T, et al. Lysosomes as key organelles in the pathogenesis of prion encephalopathies. J Pathol 1992; 166:333-41; PMID:1355530; http://dx.doi.org/10.1002/path.1711660404
    • (1992) J Pathol , vol.166 , pp. 333-341
    • Laszlo, L.1    Lowe, J.2    Self, T.3    Kenward, N.4    Landon, M.5    McBride, T.6
  • 53
    • 0034001444 scopus 로고    scopus 로고
    • Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation
    • PMID:10775631
    • Doh-Ura K, Iwaki T, Caughey B. Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation. J Virol 2000; 74:4894-7; PMID:10775631; http://dx.doi.org/10.1128/JVI.74.10.4894- 4897.2000
    • (2000) J Virol , vol.74 , pp. 4894-4897
    • Doh-Ura, K.1    Iwaki, T.2    Caughey, B.3
  • 54
    • 34447530804 scopus 로고    scopus 로고
    • Prions of fungi: Inherited structures and biological roles
    • PMID:17632572
    • Wickner RB, Edskes HK, Shewmaker F, Nakayashiki T. Prions of fungi: inherited structures and biological roles. Nat Rev Microbiol 2007; 5:611-8; PMID:17632572; http://dx.doi.org/10.1038/nrmicro1708
    • (2007) Nat Rev Microbiol , vol.5 , pp. 611-618
    • Wickner, R.B.1    Edskes, H.K.2    Shewmaker, F.3    Nakayashiki, T.4
  • 55
    • 79961133270 scopus 로고    scopus 로고
    • MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response
    • PMID:21782231
    • Hou F, Sun L, Zheng H, Skaug B, Jiang QX, Chen ZJ. MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response. Cell 2011; 146:448-61; PMID:21782231; http://dx.doi.org/10.1016/j. cell.2011.06.041
    • (2011) Cell , vol.146 , pp. 448-461
    • Hou, F.1    Sun, L.2    Zheng, H.3    Skaug, B.4    Jiang, Q.X.5    Chen, Z.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.