Stimulation of GSH synthesis to prevent oxidative stress-induced apoptosis by hydroxytyrosol in human retinal pigment epithelial cells: Activation of Nrf2 and JNK-p62/SQSTM1 pathways

Journal of Nutritional Biochemistry

Volumn 23, Issue 8, 2012, Pages 994-1006

  Zou, Xuan ^a,b   Feng, Zhihui ^c,d,f   Li, Yuan ^d   Wang, Ying ^e   Wertz, Karin ^e   Weber, Peter ^e   Fu, Yan ^a,b   Liu, Jiankang ^d  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^d XI'AN JIAOTONG UNIVERSITY   (China)

^e DSM RESOLVE   (Netherlands)

^f UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Glutamyl cysteine ligase (GCL); Buthionine S,R sulfoximine (BSO); Heme oxygenase 1 (HO 1); Mitochondrial function; NAD(P)H:quinone oxidoreductase (NQO 1); Tert Butyl hydroperoxide (t BHP)

Indexed keywords

GLUTATHIONE; HYDROXYTYROSOL; OLIVE OIL; PROTEIN P62; TRANSCRIPTION FACTOR NRF2;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; OLIVE; OXIDATIVE STRESS; PIGMENT CELL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTIOXIDANTS; APOPTOSIS; CELL LINE; GLUTATHIONE; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PHENYLETHYL ALCOHOL; RETINAL PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION;

EID: 84864010629     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2011.05.006     Document Type: Article

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