Effect of erythropoietin on hepcidin expression in hemojuvelin-mutant mice

Blood Cells, Molecules, and Diseases

Volumn 44, Issue 4, 2010, Pages 257-261

  Krijt, Jan ^a   Jonášová, Anna ^b   Neuwirtová, Radana ^b   Nečas, Emanuel ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

BMP6; Erythropoietin; Hemojuvelin; Hepcidin; Iron

Indexed keywords

BONE MORPHOGENETIC PROTEIN; ERYTHROPOIETIN; HEMOJUVELIN; HEPCIDIN; IRON; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; C57BL 6 MOUSE; CONTROLLED STUDY; DOWN REGULATION; ERYTHROPOIESIS; EXPERIMENTAL MOUSE; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; IN VIVO STUDY; IRON OVERLOAD; IRON STORAGE; IRRADIATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BONE MORPHOGENETIC PROTEIN 6; DOWN-REGULATION; ERYTHROPOIESIS; ERYTHROPOIETIN, RECOMBINANT; FEMALE; FERRIC COMPOUNDS; GENE EXPRESSION REGULATION; IRON OVERLOAD; LIVER; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; POLYSACCHARIDES; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

MUS;

EID: 77950300851     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2010.02.012     Document Type: Article

References (27)

1. Beutler E. Iron storage disease: facts, fiction and progress. Blood Cells Mol. Dis. 2007, 39:140-147.
2. Andrews N.C. Forging a field: the golden age of iron biology. Blood 2008, 112:219-230.
3. Nemeth E., Ganz T. The role of hepcidin in iron metabolism. Acta Haematol. 2009, 122:78-86.
4. Pigeon C., Ilyin G., Courselaud B., et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J. Biol. Chem. 2001, 276:7811-7819.
5. Nicolas G., Chauvet C., Viatte L., et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J. Clin. Invest. 2002, 110:1037-1044.
6. Frazer D.M., Inglis H.R., Wilkins S.J., et al. Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis. Gut 2004, 53:1509-1515.
7. Latunde-Dada G.O., McKie A.T., Simpson R.J. Animal models with enhanced erythropoiesis and iron absorption. Biochim. Biophys. Acta 2006, 1762:414-423.
8. Finch C. Regulators of iron balance in humans. Blood 1994, 84:1697-1702.
9. Nicolas G., Viatte L., Bennoun M., et al. Hepcidin, a new iron regulatory peptide. Blood Cells Mol. Dis. 2002, 29:327-335.
10. Tanno T., Bhanu N.V., Oneal P.A., et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat. Med. 2007, 13:1096-1101.
11. Cazzola M., Della Porta M.G., Malcovati L. Clinical relevance of anemia and transfusion iron overload in myelodysplastic syndromes. Hematology Am. Soc. Hematol. Educ. Program 2008, 166-175.
12. Cermák J. Erythropoietin administration may potentiate mobilization of storage iron in patients on oral iron chelation therapy. Hemoglobin 2006, 30:105-112.
13. Murphy P.T., Mitra S., Gleeson M., et al. Urinary hepcidin excretion in patients with low grade myelodysplastic syndrome. Br. J. Haematol. 2009, 144:451-452.
14. Vokurka M., Krijt J., Sulc K., Necas E. Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis. Physiol. Res. 2006, 55:667-674.
15. Pak M., Lopez M.A., Gabayan V., et al. Suppression of hepcidin during anemia requires erythropoietic activity. Blood 2006, 108:3730-3735.
16. Nemeth E. Iron regulation and erythropoiesis. Curr. Opin. Hematol. 2008, 15:169-175.
17. Huang H., Constante M., Layoun A., Santos M.M. Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli. Blood 2009, 113:3593-3599.
18. Kautz L., Meynard D., Monnier A., et al. Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood 2008, 112:1503-1509.
19. Meynard D., Kautz L., Darnaud V., et al. Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat. Genet. 2009, 41:478-481.
20. Andriopoulos B., Corradini E., Xia Y., et al. BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat. Genet. 2009, 41:482-487.
21. Tanno T., Porayette P., Sripichai O., et al. Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood 2009, 114:181-186.
22. Pinto J.P., Ribeiro S., Pontes H., et al. Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha. Blood 2008, 111:5727-5733.
23. Niederkofler V., Salie R., Arber S. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J. Clin. Invest. 2005, 115:2180-2186.
24. Wang R.H., Li C., Xu X., et al. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab. 2005, 2:399-409.
25. Yu P.B., Hong C.C., Sachidanandan C., et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat. Chem. Biol. 2008, 4:33-41.
26. Casanovas G., Mleczko-Sanecka K., Altamura S., et al. Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD. J. Mol. Med. 2009, 87:471-480.
27. Ramey G., Deschemin J.C., Vaulont S. Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes. Haematologica 2009, 94:765-772.