Immunohistological localisation of human FAT1 (hFAT) protein in 326 breast cancers. Does this adhesion molecule have a role in pathogenesis?

Pathology

Volumn 38, Issue 2, 2006, Pages 125-131

  Kwaepila, Nantana ^a   Burns, Gordon ^b   Leong, Anthony S Y ^a  

^a JOHN HUNTER HOSPITAL   (Australia)

^b UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

Adhesion proteins; Breast cancer; Carcinogenesis; hFAT; Immunohistochemistry

Indexed keywords

AVIDIN; BETA CATENIN; BIOTIN; CELL ADHESION MOLECULE; HFAT 1 PROTEIN; PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN;

ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER GRADING; CANCER INFILTRATION; CANCER INVASION; CARCINOMA IN SITU; CELL MIGRATION; CONTROLLED STUDY; DUCTAL CARCINOMA IN SITU; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LOBULAR CARCINOMA IN SITU; MAJOR CLINICAL STUDY; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TISSUE SECTION;

EID: 33645554761     PISSN: 00313025     EISSN: 14653931     Source Type: Journal    
DOI: 10.1080/00313020600559975     Document Type: Article

References (22)

1. Mahoney PA, Weber U, Onofrechuk P, Biessmann H, Bryant PJ, Goodman CS. The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily. Cell 1991; 67: 853-88.
2. Dunne J, Hanby MH, Poulsom R, et al. Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-35 and encodes a putative adhesion molecule. Genomics 1995; 30: 207-23.
3. Yap AS, Brieher WM, Gumbiner BM. Molecular and functional analysis of cadherin-based adherens junctions. Annu Rev Cell Dev Biol 1997; 13: 119-46.
4. Gamallo C, Palacios J, Suarez A, et al. Correlation of E-cadherin expression with differentiation grade and histological type in breast carcinoma. Am J Pathol 1993; 142: 987-93.
5. Siitonen SM, Kononen JT, Helin HJ, Rantala IS, Holli KA, Isola JJ. Reduced E-cadherin expression is associated with invasiveness and unfavorable prognosis in breast cancer. Am J Clin Pathol 1996; 105: 394-02.
6. Sormunen R, Leong AS-Y, Vaaraniemi JP, Fernando SSE, Eskelinen SM. Immunolocalization of Fodrin, E-cadherin and beta-catenin adhesion complex in infiltrating ductal carcinoma of the breast - comparison with an in vitro model. J Pathol 1999; 187: 416-23.
7. Nieman MT, Prudoff RS, Johnson KR, Wheelock MJ. N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol 1999; 147: 631-43.
8. Hazan RB, Phillips GR, Qiao RF, Norton L, Aaronson SA. Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion and metastasis. J Cell Biol 2000; 148: 779-90.
9. Bryant PJ, Huettner B, Held Jr LI, Ryerse J, Szidonya J. Mutations at the fat locus interfere with cell proliferation control and epithelial morphogenesis in Drosophila. Dev Biol 1998; 129: 541-54.
10. Moeller MJ, Soofi A, Braun GS, et al. Protocadherin FAT1 binds Ena/VASP proteins and is necessary for actin dynamics and cell polarization. EMBO J 2004; 23: 3769-79.
11. Tanoue T, Takeichi M. New insights into Fat cadherins. J Cell Sci 2005; 118: 2347-53.
12. Tavassoli FA, Devilee P. World Health Organization Classification of Tumours. Tumours of the Breast and Female Genital Organs. Lyon: IARC Press, 2003.
13. Elston CW, Ellis JO. Pathological prognostic factors in breast cancer: experience from a long study with long-term follow-up. Histopathology 1991; 19: 403-10.
14. Connolly JL, Boyages J, Nixon AJ, et al. Predictors of recurrence after conservative surgery and radiation therapy for invasive breast cancer. Mod Pathol 1998; 11: 134-9.
15. Wood B, Leong AS-Y. The biology and diagnostic applications of cadherins in neoplasia: a review. Pathology 2003; 35: 101-5.
16. Down M, Power M, Smith SI, et al. Cloning and expression of the large zebrafish protocadherin gene. Fat. Gene Expr Patterns 2005; 5: 483-90.
17. Ma D, Yang CH, McNeill MA, Simon MA, Axelrod JD. Fidelity in planar cell polarity signalling. Nature 2003; 421: 543-7.
18. Castillejo-Lopez C, Martinez WM, Baumgartner S. The fat-like gene of Drosophila is the true orthologue of vertebrate Fat cadherins and is involved in the formation of tubular organs. J Biol Chem 2004; 279: 24034-43.
19. Sherwood DR, Butler JA, Kramer JM, Sternberg PW. Fos-1 promotes basement-membrane removal during anchor-cell invasion in C elegans. Cell 2005; 121: 951-62.
20. Ciani L, Patel A, Allen ND, Ffrench-Constant C. Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant cyclopia and anophthalmia phenotype. Mol Cell Biol 2003; 23: 3575-82.
21. Leong AS-Y, Sormunen RT, Vinyuvat S, Hamdani RW, Suthipintawong C. Biologic markers in ductal carcinoma in situ and concurrent infiltrating carcinoma. Am J Clin Pathol 2001; 115: 709-18.
22. Tanoue T, Takeichi M. Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact. J Cell Biol 2004; 165: 517-28.