Depression and cardiovascular disease in women: Is there a common immunological basis? A theoretical synthesis

Therapeutic Advances in Cardiovascular Disease

Volumn 8, Issue 2, 2014, Pages 56-69

  Wright, Lauren ^a   Simpson, William ^a   Van Lieshout, Ryan J ^a   Steiner, Meir ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

cardiovascular disease; depression; proinflammatory cytokines; regulatory T cells; sex differences

Indexed keywords

ANGIOTENSIN II; CYTOKINE; SEROTONIN;

CARDIOVASCULAR DISEASES; COMPLICATION; DEPRESSION; FEMALE; HUMAN; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IMMUNOLOGY; INFLAMMATION; MALE; PHYSIOLOGY; PREECLAMPSIA; PREGNANCY; REGULATORY T LYMPHOCYTE; SEX DIFFERENCE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; COMORBIDITY; CYTOKINE RELEASE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNE SYSTEM; INFORMATION RETRIEVAL; MEDLINE; NEUROTRANSMISSION; PERINATAL DEPRESSION; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW;

ANGIOTENSIN II; CARDIOVASCULAR DISEASES; CYTOKINES; DEPRESSION; FEMALE; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INFLAMMATION; MALE; PITUITARY-ADRENAL SYSTEM; PRE-ECLAMPSIA; PREGNANCY; SEROTONIN; SEX FACTORS; T-LYMPHOCYTES, REGULATORY;

EID: 84897831356     PISSN: 17539447     EISSN: 17539455     Source Type: Journal    
DOI: 10.1177/1753944714521671     Document Type: Review

References (141)

1. Afshan G. Afzal N. Qureshi S. (2012) CD4+ CD25 (hi) regulatory T cells in healthy males and females mediate gender difference in the prevalence of autoimmune diseases. Clin Lab 58: 567–571.
2. Anacker C. Zunszain P. Carvalho L. Pariante C. (2011) The glucocorticoid receptor: pivot of depression and of antidepressant treatment? Psychoneuroendocrinology 36: 415–425.
3. Andreen L. Nyberg S. Turkmen S. van Wingen G. Fernandez G. Backstrom T. (2009) Sex steroid induced negative mood may be explained by the paradoxical effect mediated by GABA(A) modulators. Psychoneuroendocrinology 34: 1121–1132.
4. Ay-Woan P. Sarah C. LyInn C. Tsyr-Jang C. Ping-Chuan H. (2006) Quality of life in depression: Predictive models. Qual Life Res 15: 39–48.
5. Baghai T. Binder E. Schule C. Salyakina D. Eser D. Lucae S. Bondy B. (2006) Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism. Mol Psychiatry 11: 1003–1015.
6. Bai X. Li J. Zhou L. Li X. (2009) Influence of the menstrual cycle on nonlinear properties of heart rate variability in young women. Am J Physiol 297: H765–H774.
7. Beers D. Henkel J. Zhao W. Wang J. Huang A. Wen S. et al. (2011) Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis. Brain 134: 1293–1314.
8. Best L. Saxena R. Anderson C. Barnes M. Hakonarson H. Falcon G. Keating B. (2013) Two variants of the C-reactive protein gene are associated with risk of pre-eclampsia in an American Indian population. PloS ONE 8: e71231.
9. Bethea C. Mirkes S. Shively C. Adams M. (2000) Steroid regulation of tryptophan hydroxylase protein in the dorsal raphe of macaques. Biol Psychiatry, 47: 562–576.
10. Bhasin P. Kapoor S. (2013) Pregnancy complications and calculated cardiovascular risk in urban women: do we envisage an association? J Urban Health 5: 1–14.
11. Blier P. Ward N. (2003) Is there a role for 5-HT1A agonists in the treatment of depression? Biol Psychiatry 53: 193–203.
12. Blom E. Jansen P. Verhulst F. Hofman A. Raat H. Jaddoe V. et al. (2010) Perinatal complications increase the risk of postpartum depression. The Generation R Study. Int J Obstet Gynaecol 117: 1390–1398.
13. Brown E. Varghese F. McEwen B. (2004) Association of depression with medical illness: does cortisol play a role? Biol Psychiatry 55: 1–9.
14. Cai W. Khaoustov V. Xie Q. Pan T. Le W. Yoffe B. (2005) Interferon-alpha-inducedmodulation of glucocorticoid and serotonin receptors as a mechanism of depression. J Hepatol 42:880–887.
15. Carl-McGrath S. Graentzdoerffer I. Lendeckel U. Ebert M. Roecken C. (2009) Angiotensin II-generating enzymes, angiotensin-converting enzyme (ACE) and mast cell chymase (CMA1), in gastric inflammation may be regulated by H. pylori and associated cytokines. Pathology 41: 419–427.
16. Carnevali L. Mastorci F. Audero E. Graiani G. Rossi S. Macchi E. et al. (2012) Stress-induced susceptibility to sudden cardiac death in mice with altered serotonin homeostasis. PloS ONE 7: e41184.
17. Conrad K. Miles T. Benyo D. (1998) Circulating levels of immunoreactive cytokines in women with pre-eclampsia. Am J Reprod Immunol 40: 102–111.
18. Cote F. Fligny C. Fromes Y. Mallet J. Vodjdani G. (2004) Recent advances in understanding serotonin regulation of cardiovascular function. Trends Mol Med 10: 232–238.
19. D'Agostino R. Sr. Grundy S. Sullivan L. Wilson P. (2001) Validation of the Framingham coronary heart disease prediction scores. J Am Med Assoc 286: 180–187.
20. Dantzer R. O'Connor J. Freund G. Johnson R. Kelley K. (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9: 46–57.
21. Dekker M. Koper J. van Aken M. Pols H. Hofman A. de Jong F. et al. (2008) Salivary cortisol is related to atherosclerosis of carotid arteries. J Clin Endocrinol Metab 93: 3741–3747.
22. Delahaije D. Dirksen C. Peeters L. Smits L. (2013) Anxiety and depression following pre-eclampsia or hemolysis, elevated liver enzymes, and low platelets syndrome. A systematic review. Acta Obstet Gyn Scan 92: 746–761.
23. Dergacheva O. Kamendi H. Wang X. Mendelowitz D. (2011) 5HT1A receptors inhibit glutamate inputs to cardiac vagal neurons post-hypoxia/hypercapnia. Resp Physiol Neurobiol 179: 254–258.
24. de Santis A. DiezRoux A. Hajat A. Aiello A. Golden S. Jenny N. et al. (2012) Associations of salivary cortisol levels with inflammatory markers: the multi-ethnic study of atherosclerosis. Psychoneuroendocrinology 37: 1009–1018.
25. Dowlati Y. Herrmann N. Swardfager W. Liu H. Sham L. Reim E. Lanctôt K. (2010) A meta-analysis of cytokines in major depression. Biol Psychiatry 67: 446–457.
26. Durk T. Panther E. Muller T. Sorichter S. Ferrari D. Pizzirani C. et al. (2005) 5-Hydroxytryptamine modulates cytokine and chemokine production in LPS-primed human monocytes via stimulation of different 5-HTR subtypes. Int Immunol 17: 599–606.
27. Ellis J. Wennerholm U. Bengtsson A. Lilja H. Pettersson A. Sultan B. et al. (2001) Levels of dimethylarginines and cytokines in mild and severe pre-eclampsia. Acta Obstet Gyn Scan 80: 602–608.
28. Fallarino F. Grohmann U. (2011) Using an ancient tool for igniting and propagating immune tolerance: IDO as an inducer and amplifier of regulatory T cell functions. Curr Med Chem 18: 2215–2221.
29. Ferrario C. Strawn W. (2006) Role of the renin–angiotensin-aldosterone system and pro-inflammatory mediators in cardiovascular disease. Am J Cardiol 98: 121–128.
30. Firouzabadi N. Shafiei M. Bahramali E. Ebrahimi S. Bakhshandeh H. Tajik N. (2012) Association of angiotensin-converting enzyme (ACE) gene polymorphism with elevated serum ACE activity and major depression in an Iranian population. Psychiatry Res 200: 336–342.
31. Foks A. Frodermann V. ter Borg M. Habets K. Bot I. Zhao Y. et al. (2011) Differential effects of regulatory T cells on the initiation and regression of atherosclerosis. Atherosclerosis 218: 53–60.
32. Freedland K. Carney R. (2013) Depression as a risk factor for adverse outcomes in coronary heart disease. BMC Med 11: 131.
33. Gadek-Michalska A. Tadeusz J. Rachwalska P. Spyrka J. Bugajski J. (2011) Effect of prior stress on interleukin-1 beta and HPA axis responses to acute stress. Pharmacol Rep 63: 1393–1403.
34. Gavin N. Gaynes B. Lohr K. Meltzer-Brody S. Gartlehner G. Swinson T. (2005) Perinatal depression – a systematic review of prevalence and incidence. Obstet Gyn 106: 1071–1083.
35. Glassman A. (2007) Depression and cardiovascular co-morbidity. Dialogue Clin Neurosci 9: 9–17.
36. Grippo A. Johnson A. (2009) Stress, depression and cardiovascular dysregulation: a review of neurobiological mechanisms and the integration of research from preclinical disease models. Stress 12: 1–21.
37. Groenink L. Pattij T. de Jongh R. van der Guten J. Oosting R. Dirks A. et al. (2003) 5-HT1A receptor knockout mice and mice overexpressing corticotropin-releasing hormone in models of anxiety. Eur J Pharmacol 463: 1–3.
38. Hamer M. Endrighi R. Venuraju S. Lahiri A. Steptoe A. (2012) Cortisol responses to mental stress and the progression of coronary artery calcification in healthy men and women. PloS ONE 7: e31356.
39. Hamer M. Malan L. (2010) Psychophysiological risk markers of cardiovascular disease. Neurosci Biobehav Rev 35: 76–83.
40. Hamon M. Blier P. (2013) Monoamine neurocircuitry in depression and strategies for new treatments. Prog Neuro-Psychoph 45: 54–65.
41. Hansson G. Hermansson A. (2011) The immune system in atherosclerosis. Nat Immunol 12: 204–212.
42. Hensler J. (2003) Regulation of 5-HT1A receptor function in brain following agonist or antidepressant administration. Life Sci 72: 1665–1682.
43. Henry J. (1992) Biological basis of the stress response. Integr Physiol Behav Sci 27: 66–83.
44. Herbert J. (2013) Cortisol and depression: three questions for psychiatry. Psychol Med 43: 449–469.
45. Hermes W. Tamsma J. Grootendorst D. Franx A. van der Post J. van Pampus M. et al. (2013) Cardiovascular risk estimation in women with a history of hypertensive pregnancy disorders at term: a longitudinal follow-up study. BMC Pregnancy Childbirth 13: 126.
46. Himmerich H. Binder E. Kuenzel H. Schuld A. Lucae S. Uhr M. et al. (2006) Successful antidepressant therapy restores the disturbed interplay between TNF-alpha system and HPA axis. Biol Psychiat 60: 882–888.
47. Himmerich H. Milenović S. Fulda S. Plümäkers B. Sheldrick A. Michel T. Rink L. (2010) Regulatory T cells increased while IL-1β decreased during antidepressant therapy. J Psychiat Res 44: 1052–1057.
48. Hoedjes M. Berks D. Vogel I. Franx A. Bangma M. Darlington A. et al. (2011) Postpartum depression after mild and severe pre-eclampsia. J Womens Health 20: 1535–1542.
49. Holsboer F. Ising M. (2008) Central CRH system in depression and anxiety – evidence from clinical studies with CRH< sub> 1 receptor antagonists. Eur J Pharmacol 583: 350–357.
50. Horiuchi J. Atik A. Iigaya K. McDowall L. Killinger S. Dampney R. (2011) Activation of 5-hydroxytryptamine-1A receptors suppresses cardiovascular responses evoked from the paraventricular nucleus. Am J Physiol Regul Integr Comp Physiol 301: R1088–R1097.
51. Huang H. He J. Yuan Y. Aoyagi E. Takenaka H. Itagaki T. et al. (2008) Opposing effects of estradiol and progesterone on the oxidative stress-induced production of chemokine and proinflammatory cytokines in murine peritoneal macrophages. J Med Invest 55: 133–141.
52. Huffman J. Celano C. Beach S. Motiwala S. Januzzi J. (2013) Depression and cardiac disease: epidemiology, mechanisms, and diagnosis. Cardiovasc Psychiat Neurol 2013: 695925.
53. Ito T. Schaffer S. Azuma J. (2013) The effect of taurine on chronic heart failure: actions of taurine against catecholamine and angiotensin II. Amino Acids 31 May (epub ahead of print). doi: 10.1007/s00726-013-1507-z.
54. Jaffre F. Bonnin P. Callebert J. Debbabi H. Setola V. Doly S. et al. (2009) Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy. Circ Res 104: 113–123
55. Jaffre F. Callebert J. Sarre A. Etienne N. Nebigil C. Launay J. et al. (2004) Involvement of the serotonin 5-HT2B receptor in cardiac hypertrophy linked to sympathetic stimulation control of interleukin-6, interleukin-1 beta, and tumor necrosis factor-alpha cytokine production by ventricular fibroblasts. Circulation 110: 969–974.
56. Kageyama K. Suda T. (2008) Regulatory mechanisms underlying corticotropin-releasing factor gene expression in the hypothalamus. Endocrine J 56: 335–344.
57. Katoh N. Soga F. Nara T. Tamagawa-Mineoka R. Nin M. Kotani H. et al. (2006) Effect of serotonin on the differentiation of human monocytes into dendritic cells. Clin Exp Immunol 146: 354–361.
58. Kessler R. Berglund P. Demler O. Jin R. Merikangas K. Walters E. (2005) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Co-morbidity Survey Replication. Arch Gen Psychiat 62: 593.
59. Kim S. Lee H. Lee G. Oh S. Shin M. Shim I. et al. (2012) CD4(+)CD25(+) regulatory T cell depletion modulates anxiety and depression-like behaviors in mice. PloS ONE 7: e42054.
60. Kim D. Sockol L. Sammel M. Kelly C. Moseley M. Epperson C. (2013) Elevated risk of adverse obstetric outcomes in pregnant women with depression. Arch Womens Ment Health 5: 1–8.
61. Klingenberg R. Gerdes N. Badeau R. Gisterå A. Strodthoff D. Ketelhuth D. et al. (2013) Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis. J Clin Invest 123: 1323–1334.
62. Laresgoiti-Servitje E. (2013) A leading role for the immune system in the pathophysiology of pre-eclampsia. J Leukocyte Biol 94: 247–257.
63. Layé S. (2010) Polyunsaturated fatty acids, neuroinflammation and well being. Prostag Leukotr Ess 82: 295–303.
64. Lee J. Lydon J. Kim C. (2012) Progesterone suppresses the mTOR pathway and promotes generation of induced regulatory T cells with increased stability. Eur J Immunol 42: 2683–2696.
65. Li Y. Xiao B. Qiu W. Yang L. Hu B. Tian X. et al. (2010) Altered expression of CD4(+)CD25(+) regulatory T cells and its 5-HT1a receptor in patients with major depression disorder. J Affect Disord 124: 68–75.
66. Liu X. Ji Q. Huang Y. Zeng Q. (2011) Th 17 response promotes angiotensin II-induced atherosclerosis. Med Hypotheses 76: 593–595.
67. Lokuge S. Frey B. Foster J. Soares C. Steiner M. (2010) The rapid effects of estrogen: a mini-review. Behav Pharmacol 21: 465–472.
68. Lupien S. McEwen B. Gunnar M. Heim C. (2009) Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Rev Neurosci 10: 434–445.
69. Mastelari R. de Abreu S. de Aguiar Corrêa F. de Souza H. Martins-Pinge M. (2012) Glutamatergic neurotransmission in the hypothalamus PVN on heart rate variability in exercise trained rats. Autonomic Neurosci 170: 42–47.
70. Mastrogiannis D. Giamouzis G. Dardiotis E. Karayannis G. Chroub-Papavaiou A. Kremeti D. et al. (2012) Depression in patients with cardiovascular disease. Cardiol Res Pract 2012: 794762.
71. Mbachu I. Udigwe G. Okafor C. Umeonunihu O. Ezeama C. Eleje G. (2013) The pattern and obstetric outcome of hypertensive disorders of pregnancy in Nnewi, Nigeria. Nigerian J Med 22: 117–122.
72. McDonald S. Ray J. Teo K. Jung H. Salehian O. Yusuf S. et al. (2013) Measures of cardiovascular risk and subclinical atherosclerosis in a cohort of women with a remote history of pre-eclampsia. Atherosclerosis 229: 234–239.
73. Mendelson S. (2000) The current status of the platelet 5-HT2A receptor in depression. J Affect Disord 57: 13–24.
74. Messerli-Buergy N. Molloy G. Wikman A. Perkins-Porras L. Randall G. Steptoe A. (2012) Cortisol levels and history of depression in acute coronary syndrome patients. Psychol Med 42: 1815–1823.
75. Meyburgh D. Malan L. van Rooyen J. Potgieter J. (2012) Cardiovascular, cortisol and coping responses in urban Africans: the SAPBA study. Cardiovasc J Africa 23: 28–33.
76. Meyer J. (2013) Neurochemical imaging and depressive behaviours. Curr Top Behav Neurosci 14: 101–134.
77. Mitsuhashi M. Tanaka A. Fujisawa C. Kawamoto K. Itakura A. Takaku M. et al. (2001) Necessity of thromboxane A 2 for initiation of platelet-mediated contact sensitivity: dual activation of platelets and vascular endothelial cells. J Immunol 166: 617–623.
78. Möller-Leimkühler A. (2010) Higher co-morbidity of depression and cardiovascular disease in women: a biopsychosocial perspective. World J Biol Psychiatry 11: 922–933.
79. Molvarec A. Szarka A. Walentin S. Beko G. Karadi I. Prohaszka Z. et al. (2011) Serum heat shock protein 70 levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in women with pre-eclampsia. Clinica Chimica Acta 412: 1957–1962.
80. Müller N. Myint A. Schwarz M. (2011) Inflammatory biomarkers and depression. Neurotox Res 19: 308–318.
81. Munk P. Isaksen K. Bronnick K. Kurz M. Butt N. Larsen A. (2012) Symptoms of anxiety and depression after percutaneous coronary intervention are associated with decreased heart rate variability, impaired endothelial function and increased inflammation. Int J Cardiol 158: 173–176.
82. Murphy A. Guyre P. Pioli P. (2010) Estradiol suppresses NF-κB activation through coordinated regulation of let-7a and miR-125b in primary human macrophages. J Immunol 184: 5029–5037.
83. Murray C. Vos T. Lozano R. Naghavi M. Flaxman A. Michaud C. et al. (2013) Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380: 2197–2223.
84. Myint A. Schwarz M. Müller N. (2012) The role of the kynurenine metabolism in major depression. J Neural Transm 119: 245–251.
85. Nemeroff C. Goldschmidt-Clermont P. (2012) Heartache and heartbreak – the link between depression and cardiovascular disease. Nat Rev Cardiol 9: 526–539.
86. Neubauer H. Petrak F. Zahn D. Pepinghege F. Hägele A. Pirkl P. et al. (2013) Newly diagnosed depression is associated with increased beta-thromboglobulin levels and increased expression of platelet activation markers and platelet derived CD40-CD40L. J Psychiatr Res 47: 865–871.
87. Neutel J. (2004) Effect of the renin–angiotensin system on the vessel wall: Using ACE inhibition to improve endothelial function. J Hum Hypertens 18: 599–606.
88. Nishiyama T. (2009) Acute effects of sarpogrelate, a 5-HT2A receptor antagonist on cytokine production in endotoxin shock model of rats. Eur J Pharmacol 614: 122–127.
89. O'Brien S. Fitzgerald P. Scully P. Landers A. Scott L. Dinan T. (2007) Impact of gender and menstrual cycle phase on plasma cytokine concentrations. Neuroimmunomodulation 14: 84–90.
90. Östlund E. Al-Nashi M. Hamad R. Larsson A. Eriksson M. Bremme K. et al. (2013) Normalized endothelial function but sustained cardiovascular risk profile 11 years following a pregnancy complicated by pre-eclampsia. Hypertens Res 36: 1081–1087.
91. Otte C. Marmar C. Pipkin S. Moos R. Browner W. Whooley M. (2004) Depression and 24-hour urinary cortisol in medical outpatients with coronary heart disease: The Heart and Soul Study. Biol Psychiatry 56: 241–247.
92. Palmsten K. Setoguchi S. Margulis A. Patrick A. Hernández-Díaz S. (2012) Elevated risk of pre-eclampsia in pregnant women with depression: depression or antidepressants? Am J Epidemiol 175: 988–997.
93. Ping F. Shang J. Zhou J. Zhang H. Zhang L. (2012) 5-HT1A receptor and apoptosis contribute to interferon-α-induced ‘depressive-like‘ behavior in mice. Neurosci Lett 514: 173–178.
94. Puder J. Freda P. Goland R. Wardlaw S. (2001) Estrogen modulates the hypothalamic–pituitary–adrenal and inflammatory cytokine responses to endotoxin in women. J Clin Endocrinol Metab 86: 2403–2408.
95. Pytliak M. Vargova V. Mechírová V. Felsoci M. (2011) Serotonin receptors – from molecular biology to clinical applications. Physiol Res 60: 15–25.
96. Raison C. Borisov A. Woolwine B. Massung B. Vogt G. Miller A. (2008) Interferon-α effects on diurnal hypothalamic–pituitary–adrenal axis activity: relationship with proinflammatory cytokines and behavior. Mol Psychiatry 15: 535–547.
97. Rallidis L. Varounis C. Sourides V. Charalampopoulos A. Kotakos C. Liakos G. et al. (2011) Mild depression versus C-reactive protein as a predictor of cardiovascular death: a three year follow-up of patients with stable coronary artery disease. Curr Med Res Opin 27: 1407–1413.
98. Ramchandra R. Hood S. Frithiof R. McKinley M. May C. (2013) The role of the paraventricular nucleus of the hypothalamus in the regulation of cardiac and renal sympathetic nerve activity in conscious normal and heart failure sheep. J Physiol 591: 93–107.
99. Roger V. Go A. Llyod-Jones D. Adams R. Berry J. Brown T. et al. (2011) Heart disease and stroke statistics- 2011 update. Circulation 123: e18–e209.
100. Ruiz-Ortega M. Ruperez M. Lorenzo O. Esteban V. Blanco J. Mezzano S. et al. (2002) Angiotensin II regulates the synthesis of pro-inflammatory cytokines and chemokines in the kidney. Kidney Int 62: S12–S22.
101. Ruschitzka F. Taddei S. (2012) Angiotensin-converting enzyme inhibitors: first-line agents in cardiovascular protection?. Eur Heart J 33: 1996–1998.
102. Rutledge T. Vaccarino V. Johnson D. Bittner V. Olson M. Linke S. et al. (2009) Depression and cardiovascular health care costs among women with suspected myocardial ischemia prospective results from the WISE (Women's ischemia syndrome evaluation) study. J Am Coll Cardiol 53: 176–183.
103. Saab Y. Gard P. Yeoman M. Mfarrej B. El-Moalem H. Ingram M. (2007) Renin–angiotensin-system gene polymorphisms and depression. Prog Neuropsychopharmacol Biol Psychiat 31: 1113–1118.
104. Sanner J. Frazier L. (2011) The role of serotonin in depression and clotting in the coronary artery disease population. J Cardiovasc Nurs 26: 423–429.
105. Santner-Nanan B. Peek M. Khanam R. Richarts L. Zhu E. Fazekas de St Groth B. et al. (2009) Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in pre-eclampsia. J Immunol 183: 7023–7030.
106. Sasada T. Kimura M. Yoshida Y. Kanai M. Takabayashi A. (2003) CD4(+)CD25(+) regulatory T cells in patients with gastrointestinal malignancies – possible involvement of regulatory T cells in disease progression. Cancer 98: 1089–1099.
107. Sasamura H. Nakazato Y. Hayashida T. Kitamura Y. Hayashi M. Saruta T. (1997) Regulation of vascular type 1 angiotensin receptors by cytokines. Hypertension 30: 35–41.
108. Schäfer A. Scheurlen M. Seufert J. Keicher C. Weißbrich B. Rieger P. et al. (2010) Platelet serotonin (5-HT) levels in interferon-treatedpatients with hepatitis C and its possible association with interferon-induced depression. J Hepatol 52: 10–15.
109. Schins A. Hamulyak K. Scharpe S. Lousberg R. van Melle J. Crijns H. et al. (2004) Whole blood serotonin and platelet activation in depressed post-myocardial infarction patients. Life Sci 76: 637–650.
110. Schmidt-Ott K. Kagiyama S. Phillips M. (2000) The multiple actions of angiotensin II in atherosclerosis. Regul Peptides 93: 65–77.
111. Schnatz P. Nudy M. Shively C. Powell A. O'Sullivan D. (2011) A prospective analysis of the association between cardiovascular disease and depression in middle-aged women. Menopause 18: 1096–1100.
112. Scorza M. Llado-Pelfort L. Oller S. Cortes R. Puigdemont D. Portella M. et al. (2012) Preclinical and clinical characterization of the selective 5-HT1A receptor antagonist DU-125530 for antidepressant treatment. Br J Pharmacol 167: 1021–1034.
113. Silverman M. Pearce B. Biron C. Miller A. (2005) Immune modulation of the hypothalamic–pituitary–adrenal (HPA) axis during viral infection. Viral Immunol 18: 41–78.
114. Sim Y. Park S. Kang Y. Jung J. Ryu O. Choi M. et al. (2012) Interleukin-1β (IL-1β) increases pain behavior and the blood glucose level: possible involvement of sympathetic nervous system. Pharmacol Biochem Behav 102: 170–176.
115. Skurk T. van Harmelen V. Hauner H. (2004) Angiotensin II stimulates the release of interleukin-6 and interleukin-8 from cultured human adipocytes by activation of NF-kappa B. Arterioscler Thromb Vasc Biol 24: 1199–1203.
116. Sriramula S. Cardinale J. Francis J. (2013) Inhibition of TNF in the brain reverses alterations in RAS components and attenuates angiotensin II-induced hypertension. PloS ONE 8: e63847.
117. Sriramula S. Cardinale J. Lazartigues E. Francis J. (2011) ACE 2 overexpression in the paraventricular nucleus attenuates angiotensin II-induced hypertension. Cardiovasc Res 92: 401–408.
118. Steinborn A. Schmitt E. Kisielewicz A. Rechenberg S. Seissler N. Mahnke K. et al. (2012) Pregnancy-associated diseases are characterized by the composition of the systemic regulatory T cell (Treg) pool with distinct subsets of Tregs. Clin Exp Immunol 167: 84–98.
119. Steiner M. (2011) Serotonin, depression, and cardiovascular disease: sex-specific issues. Acta Physiol (Oxf) 203: 253–258.
120. Steiner M. Dunn E. Born L. (2003) Hormones and mood: from menarche to menopause and beyond. J Affect Disord 74: 67–83.
121. Steiner M. Pearlstein T. Cohen L. Endicott J. Kornstein S. Roberts C. et al. (2006) Expert guidelines for the treatment of severe PMS, PMDD, and comorbidities: the role of SSRIs. J Women Health 15: 57–69.
122. Steptoe A. Kivimäki M. (2012) Stress and cardiovascular disease. Nat Rev Cardiol 9: 360–370.
123. Swenson J. Clinch J. (2000) Assessment of quality of life in patients with cardiac disease: the role of psychosomatic medicine. J Psychosomat Res 48: 405–415.
124. Teles A. Zenclussen A. Schumacher A. (2013) Regulatory T cells are baby's best friends. Am J Reproduct Immunol 69: 331–339.
125. Tilburgs T. Roelen D. van der Mast B. de Groot-Swings G. Kleijburg C. Scherjon S. et al. (2008) Evidence for a selective migration of fetus-specific CD4+ CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy. J Immunol 180: 5737–5745.
126. Toftegaard C. Knigge U. Kjaer A. Watanabe T. Friis-Hansen L. Warberg J. (2002) Effect of interleukin 1 beta on the HPA axis in H-1-receptor knockout mice. Neuroimmunomodulation 10: 344–350.
127. Uchiyama S. Ozaki Y. Satoh K. Kondo K. Nishimaru K. (2007) Effect of sarpogrelate, a 5-HT2A antagonist, on platelet aggregation in patients with ischemic stroke: clinical-pharmacological dose–response study. Cerebrovasc Dis 24: 264–270.
128. Velickovic N. Drakulic D. Petrovic S. Stanojevic I. Milosevic M. Horvat A. (2009) Radiation-induced HPA axis activation is associated with up-regulation of pro-inflammatory cytokines in rat brain. FEBS J 276: 269–270.
129. Verhagen J. Akdis M. Traidl-Hoffmann C. Schmid-Grendelmeier P. Hijnen D. Knol E. et al. (2006) Absence of T-regulatory cell expression and function in atopic dermatitis skin. J Allergy Clin Immunol 117: 176–183.
130. Villalon C. Centurion D. (2007) Cardiovascular responses produced by 5-hydroxytriptamine: A pharmacological update on the receptors / mechanisms involved and therapeutic implications. Naunyn-Schmiedebergs Arch Pharmacol 376: 45–63.
131. Wang Y. Yang F. Liu Y. Gao F. Jiang W. (2011) Acetylsalicylic acid as an augmentation agent in fluoxetine treatment resistant depressive rats. Neurosci Lett 499: 74–79.
132. Watson S. Mackin P. (2006) HPA axis function in mood disorders. Psychiatry 5: 166–170.
133. Weber C. Thayer J. Rudat M. Wirtz P. Zimmermann-Viehoff F. Thomas A. et al. (2010) Low vagal tone is associated with impaired post stress recovery of cardiovascular, endocrine, and immune markers. Eur J Applied Physiol 109: 201–211.
134. White K. Dempsie Y. Nilsen M. Wright A. Loughlin L. MacLean M. (2011) The serotonin transporter, gender, and 17β oestradiol in the development of pulmonary arterial hypertension. Cardiovasc Res 90: 373–382.
135. Wirth M. (2011) Beyond the HPA axis: progesterone-derived neuroactive steroids in human stress and emotion. Front Endocrinol 2: 19.
136. Wulsin L. Musselman D. Otte C. Bruce E. Ali S. Whooley M. (2009) Depression and whole blood serotonin in patients with coronary heart disease from the heart and soul study. Psychosom Med 71: 260–265.
137. Xiong Y. Yuan Z. He L. (2013) Effects of estrogen on CD4+ CD25+regulatory T cell in peripheral blood during pregnancy. Asian Pacific J Trop Med 6: 748–752.
138. Xue B. Johnson A. Hay M. (2013) Sex differences in angiotensin II-and aldosterone-induced hypertension: the central protective effects of estrogen. Am J Physiol Regul Integr Comp Physiol 305: R459–R463.
139. Yuan Y. Shimizu I. Shen M. Aoyagi E. Takenaka H. Itagaki T. et al. (2008) Effects of estradiol and progesterone on the pro-inflammatory cytokine production by mononuclear cells from patients with chronic hepatitis C. World J Gastroenterol 14: 2200–2207.
140. Zill P. Baghai T. Schüle C. Born C. Früstück C. Büttner A. et al. (2012) DNA methylation analysis of the angiotensin converting enzyme (ACE) gene in major depression. PloS ONE 7: e40479.
141. Zunszain P. Anacker C. Cattaneo A. Carvalho L. Pariante C. (2011) Glucocorticoids, cytokines and brain abnormalities in depression. Prog Neuropsychopharmacol Biol Psychiat 35: 722–729.