Regulatory mechanisms underlying corticotropin-releasing factor gene expression in the hypothalamus

Endocrine Journal

Volumn 56, Issue 3, 2009, Pages 335-344

  Kageyama, Kazunori ^a   Suda, Toshihiro ^a  

^a HIROSAKI UNIVERSITY   (Japan)

Author keywords

Corticotropin releasing factor; Cyclic AMP; Hypothalamus; Receptor; Stress

Indexed keywords

ADENYLATE CYCLASE; ARGIPRESSIN; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; CYCLIC AMP DEPENDENT PROTEIN KINASE; ESTRADIOL; ESTROGEN; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; INTERLEUKIN 6;

ADENOHYPOPHYSIS; CRF GENE; ENZYME ACTIVATION; GENE; GENE EXPRESSION; GENE REPRESSION; GENE SEQUENCE; GENETIC TRANSCRIPTION; HORMONE SYNTHESIS; HUMAN; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; NEGATIVE FEEDBACK; NERVE CELL; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY MECHANISM; REGULATORY SEQUENCE; REVIEW; SERUM RESPONSIVE ELEMENT; STRESS; THALAMUS MIDLINE NUCLEUS;

ANIMALS; ARGININE VASOPRESSIN; CORTICOTROPIN-RELEASING HORMONE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DEXAMETHASONE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGENS; FEEDBACK; FORSKOLIN; GENE EXPRESSION REGULATION; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; HYPOTHALAMUS; INTERLEUKIN-6; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; PITUITARY-ADRENAL SYSTEM; PROMOTER REGIONS, GENETIC; SERUM RESPONSE ELEMENT;

EID: 67650447356     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.K09E-075     Document Type: Review

References (59)

1. Vale W, Spiess J, Rivier C, Rivier J (1981) Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science 213: 1394-1397. (Pubitemid 12243637)
2. Whitnall MH (1993) Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system. Prog Neurobiol 40: 573-629.
3. Suda T, yajima F, Tomori N, demura H, Shizume K (1985) In vitro study of immunoreactive corticotropin- releasing factor release from the rat hypothalamus. Life Sci 37: 1499-1505.
4. Seasholtz AF, Thompson RC, douglass JO (1988) Identification of a cyclic adenosine monophosphate-responsive element in the rat corticotropin-releasing hormone gene. Mol Endocrinol 2: 1311-1319.
5. Spengler D, Rupprecht R, Van LP, Holsboer F (1992) Identification and characterization of a 3',5'-cyclic adenosine monophosphate-responsive element in the human corticotropin-releasing hormone gene promoter. Mol Endocrinol 6: 1931-1941.
6. Nomura m, ueta y, Serino R, Kabashima N, Shibuya I, yamashita H (1996) PaCaP type I receptor gene expression in the paraventricular and supraoptic nuclei of rats. Neuroreport 8: 67-70.
7. Shioda S, Shuto y, Somogyvari-Vigh a, Legradi g, Onda H, Coy dH, Nakajo S, arimura a (1997) Localization and gene expression of the receptor for pituitary adenylate cyclase-activating polypeptide in the rat brain. Neurosci Res 28: 345-354.
8. miyata a, arimura a, dahl RR, minamino N, uehara a, Jiang L, Culler MD, Coy DH (1989) Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells. Biochem Biophys Res Commun 164: 567-574.
9. grinevich V, Fournier a, Pelletier g (1997) effects of pituitary adenylate cyclase-activating polypeptide (PaCaP) on corticotropin-releasing hormone (CRH) gene expression in the rat hypothalamic paraventricular nucleus. Brain Res 773: 190-196.
10. yao m, denver RJ (2007) Regulation of vertebrate corticotropin-releasing factor genes. Gen Comp Endocrinol 153: 200-216.
11. Kageyama K, Hanada K, Iwasaki y, Sakihara S, Nigawara T, Kasckow J, Suda T (2007) Pituitary adenylate cyclase-activating polypeptide stimulates corticotropin- releasing factor, vasopressin, and interleukin- 6 gene transcription in hypothalamic 4B cells. J Encocrinol 195: 199-211.
12. yamamori e, asai m, yoshida m, Takano K, Itoi K, Oiso y, Iwasaki y (2004) Calcium/calmodulin kinase IV pathway is involved in the transcriptional regulation of the corticotropin-releasing hormone gene promoter in neuronal cells. J Mol Endocrinol 33: 639-649.
13. Kageyama K, Hanada K, Takayasu S, Iwasaki y, Sakihara S, Nigawara T, Kasckow J, Suda T (2008) Involvement of regulatory elements on corticotropin-releasing factor gene promoter in hypothalamic 4B cells. J Endocrinol Invest 31: 1079-1085.
14. agarwal a, Halvorson LM, Legradi g (2005) Pituitary adenylate cyclase-activating polypeptide (PaCaP) mimics neuroendocrine and behavioral manifestations of stress: evidence for PKa-mediated expression of the corticotropin-releasing hormone (CRH) gene. Brain Res Mol Brain Res 138: 45-57.
15. Cheng YH, Nicholson RC, King B, Chan EC, Fitter JT, Smith R (2000) glucocorticoid stimulation of corticotropin- releasing hormone gene expression requires a cyclic adenosine 3',5'-monophosphate regulatory element in human primary placental cytotrophoblast cells. J Clin Endocrinol Metab 85: 1937-1945.
16. aoki y, Iwasaki y, Katahira m, Oiso y, Saito H (1997) Regulation of the rat proopiomelanocortin gene expression in atT-20 cells. II: effects of the pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal polypeptide. Endocrinology 138: 1930-1934.
17. Boutillier AL, Monnier D, Koch B, Loeffler JP (1994) Pituitary adenyl cyclase-activating peptide: a hypophysiotropic factor that stimulates proopiomelanocortin gene transcription, and proopiomelanocortin- derived peptide secretion in corticotropic cells. Neuroendocrinology 60: 493-502. (Pubitemid 24321284)
18. Shioda S, yada T, Nakajo S, Nakaya K, Nakai y, arimura a (1997) Pituitary adenylate cyclase-activating polypeptide (PaCaP): a novel regulator of vasopressin- containing neurons. Brain Res 765: 81-90.
19. Takaki a, Huang QH, Somogyvari-Vigh a, arimura a (1994) Immobilization stress may increase plasma interleukin- 6 via central and peripheral catecholamines. Neuroimmunomodulation 1: 335-342.
20. Zhou d, Kusnecov AW, Shurin MR, dePaoli m, Rabin BS (1993) exposure to physical and psychological stressors elevates plasma interleukin 6: relationship to the activation of hypothalamic-pituitary-adrenal axis. Endocrinology 133: 2523-2530.
21. Schimpl a, Wecker e (1972) Replacement of T-cell function by a T-cell product. Nat New Biol 237: 15-17.
22. Castell JV, gomez-Lechon MJ, david m, andus T, geiger T, Trullenque R, Fabra R, Heinrich PC (1989) Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes. FEBS Lett 242: 237-239.
23. Venihaki m, dikkes P, Carrigan a, Karalis KP (2001) Corticotropin- releasing hormone regulates IL-6 expression during inflammation. J Clin Invest 108: 1159-1166.
24. Karalis K, muglia LJ, Bae d, Hilderbrand JA (1997) CRH and the immune system. J Neuroimmunol 72: 131-136.
25. Turnbull AV & Rivier CL (1999) Regulation of the hypothalamic- pituitary-adrenal axis by cytokines: actions and mechanisms of action. Physiol Rev 79: 1-71.
26. ghorbel MT, Sharman g, Leroux m, Barrett T, donovan DM, Becker KG, murphy d (2003) microarray analysis reveals interleukin-6 as a novel secretory product of the hypothalamo-neurohypophyseal system. J Biol Chem 278: 19280-19285.
27. Navarra P, Tsagarakis S, Faria MS, Rees LH, Besser gm, grossman AB (1991) Interleukins-1 and -6 stimulate the release of corticotropin-releasing hormone-41 from rat hypothalamus in vitro via the eicosanoid cyclooxygenase pathway. Endocrinology 128: 37-44.
28. Vallieres L, Rivest S (1999) Interleukin-6 is a needed proinflammatory cytokine in the prolonged neural activity and transcriptional activation of corticotropinreleasing factor during endotoxemia. Endocrinology 140: 3890-3903. (Pubitemid 30647082)
29. magiakou ma, mastorakos g, Webster e, Chrousos GP (1997) The hypothalamic-pituitary-adrenal axis and the female reproductive system. Ann N Y Acad Sci 816: 42-56.
30. Ochedalski T, Subburaju S, Wynn PC, aguilera g (2007) Interaction between oestrogen and oxytocin on hypothalamic-pituitary-adrenal axis activity. J Neuroendocrinol 19: 189-197.
31. Fonseca e, Basurto L, Velazquez S, Zarate a (2001) Hormone replacement therapy increases aCTH/dehydroepiandrosterone sulfate in menopause. Maturitas 39: 57-62.
32. altemus m, Roca C, galliven e, Romanos C, deuster P (2001) Increased vasopressin and adrenocorticotropin responses to stress in the midluteal phase of the menstrual cycle. J Clin Endocrinol Metab 86: 2525-2530.
33. Nakano y, Suda T, Sumitomo T, Tozawa F, demura H (1991) effects of sex steroids on beta-endorphin release from rat hypothalamus in vitro. Brain Res 553: 1-3.
34. dibbs KI, anteby e, mallon MA, Sadovsky y, adler S (1997) Transcriptional regulation of human placental corticotropin-releasing factor by prostaglandins and estradiol. Biol Reprod 57: 1285-1292.
35. Vamvakopoulos NC, Chrousos GP (1993) evidence of direct estrogenic regulation of human corticotropin-releasing hormone gene expression. Potential implications for the sexual dimorphism of the stress response and immune/inflammatory reaction. J Clin Invest 92: 1896-1902.
36. Shughrue PJ, Lane MV, merchenthaler I (1997) Comparative distribution of estrogen receptor-alpha and -beta mRNa in the rat central nervous system. J Comp Neurol 388: 507-525.
37. Laflamme N, Nappi RE, drolet g, Labrie C, Rivest S (1998) expression and neuropeptidergic characterization of estrogen receptors (eRalpha and eRbeta) throughout the rat brain: anatomical evidence of distinct roles of each subtype. J Neurobiol 36: 357-378.
38. mitra SW, Hoskin e, yudkovitz J, Pear L, Wilkinson HA, Hayashi S, Pfaff DW, Ogawa S, Rohrer SP, Schaeffer JM, mcewen BS, alves SE (2003) Immunolocalization of estrogen receptor beta in the mouse brain: comparison with estrogen receptor alpha. Endocrinology 144: 2055-2067.
39. Price RH Jr, Lorenzon N, Handa RJ (2000) differential expression of estrogen receptor beta splice variants in rat brain: identification and characterization of a novel variant missing exon 4. Brain Res Mol Brain Res 80: 260-268. (Pubitemid 30687345)
40. Ogura e, Kageyama K, Hanada K, Kasckow J, Suda T (2008) effects of estradiol on regulation of corticotropin- releasing factor gene and interleukin-6 production via estrogen receptor type beta in hypothalamic 4B cells. Peptides 29: 456-464.
41. miller WJ, Suzuki S, miller LK, Handa R, uht RM (2004) estrogen receptor (eR) beta isoforms rather than eRalpha regulate corticotropin-releasing hormone promoter activity through an alternate pathway. J Neurosci 24: 10628-10635.
42. Tellam DJ, Perone MJ, dunn IC, Radovick S, Brennand J, Rivier JE, Castro MG, Lovejoy DA (1998) direct regulation of gnRH transcription by CRFlike peptides in an immortalized neuronal cell line. Neuroreport 9: 3135-3140.
43. Liu MM, albanese C, anderson CM, Hilty K, Webb P, uht RM, Price RH Jr, Pestell RG, Kushner PJ (2002) Opposing action of estrogen receptors alpha and beta on cyclin d1 gene expression. J Biol Chem 277: 24353-24360.
44. Chen XN, Zhu H, meng QY, Zhou JN (2008) estrogen receptor-alpha and -beta regulate the human corticotropin- releasing hormone gene through similar pathways. Brain Res 1223: 1-10.
45. malkoski SP, dorin RI (1999) Composite glucocorticoid regulation at a functionally defined negative glucocorticoid response element of the human corticotropin- releasing hormone gene. Mol Endocrinol 13: 1629-1644.
46. guardiola-diaz HM, Kolinske JS, gates LH, Seasholtz AF (1996) Negative glucorticoid regulation of cyclic adenosine 3', 5'-monophosphate-stimulated corticotropin- releasing hormone-reporter expression in atT-20 cells. Mol Endocrinol 10: 317-329.
47. Karagianni N, Tsawdaroglou N (1994) The c-fos serum response element (SRe) confers negative response to glucocorticoids. Oncogene 9: 2327-2334. (Pubitemid 24228684)
48. King BR, Smith R, Nicholson RC (2002) Novel glucocorticoid and camP interactions on the CRH gene promoter. Mol Cell Endocrinol 194: 19-28. (Pubitemid 35291916)
49. Jacobson L, Sharp FR, dallman MF (1990) Induction of fos-like immunoreactivity in hypothalamic corticotropin- releasing factor neurons after adrenalectomy in the rat. Endocrinology 126: 1709-1719.
50. Legradi g, Holzer d, Kapcala LP, Lechan RM (1997) glucocorticoids inhibit stress-induced phosphorylation of CReB in corticotropin-releasing hormone neurons of the hypothalamic paraventricular nucleus. Neuroendocrinology 66: 86-97.
51. van der Laan S, Lachize SB, Vreugdenhil e, de Kloet ER, meijer OC (2008) Nuclear receptor coregulators differentially modulate induction and glucocorticoid receptor-mediated repression of the corticotropin-releasing hormone gene. Endocrinology 149: 725-732.
52. ma XM, aguilera g (1999) differential regulation of corticotropin- releasing hormone and vasopressin transcription by glucocorticoids. Endocrinology 140: 5642-5650.
53. Foulkes NS, Borrelli e, Sassone-Corsi P (1991) CRem gene: use of alternative dNa-binding domains generates multiple antagonists of camP-induced transcription. Cell 64: 739-749.
54. molina CA, Foulkes NS, Lalli e, Sassone-Corsi P (1993) Inducibility and negative autoregulation of CRem: an alternative promoter directs the expression of ICeR, an early response repressor. Cell 75: 875-886.
55. Lalli e, Sassone-Corsi P (1994) Signal transduction and gene regulation: the nuclear response to camP. J Biol Chem 269: 17359-17362.
56. Krebs DL, Hilton DJ (2000) SOCS: physiological suppressors of cytokine signaling. J Cell Sci 113: 2813-2819.
57. auernhammer CJ, Bousquet C, melmed S (1999) autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter. Proc Natl Acad Sci USA 96: 6964-6969.
58. Ram PA, Waxman DJ (1999) SOCS/CIS protein inhibition of growth hormone-stimulated STaT5 signaling by multiple mechanisms. J Biol Chem 274: 35553-35561.
59. Schmitz J, Weissenbach m, Haan S, Heinrich PC, Schaper F (2000) SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. J Biol Chem 275: 12848-12856.