Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy

Circulation Research

Volumn 104, Issue 1, 2009, Pages 113-123

  Jaffré, Fabrice ^a,b,c   Bonnin, Philippe ^d   Callebert, Jacques ^d,e   Debbabi, Haythem ^d   Setola, Vincent ^a,b,c   Doly, Stéphane ^a,b,c   Monassier, Laurent ^a,b,c   Mettauer, Bertrand ^f   Blaxall, Burns C ^g   Launay, Jean Marie ^d,e   Maroteaux, Luc ^a,c  

^a INSERM   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c INSTITUT DU FER À MOULIN   (France)

^d HÔPITAL LARIBOISIÈRE   (France)

^e Hôpital Lariboisière ^*  (France)

^f Service de Cardiologie   (France)

^g UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Fibroblast; Heart failure; Hypertrophy; Interleukins; Sympathetic nervous system

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; ANGIOTENSINOGEN; EPIDERMAL GROWTH FACTOR RECEPTOR; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; HETERODIMER; INTERLEUKIN 1BETA; INTERLEUKIN 6; ISOPRENALINE; NORADRENALIN; SEROTONIN; SEROTONIN 2B RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; HEPARIN-BINDING EGF-LIKE GROWTH FACTOR; PROTEIN TYROSINE KINASE; SEROTONIN ANTAGONIST; SIGNAL PEPTIDE;

ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIAC PATIENT; CELL STIMULATION; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FIBROBLAST; GENE OVEREXPRESSION; HEART DISEASE; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HUMAN; MALE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; NORADRENALIN BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; ADULT; ANIMAL; BLOOD; CELL CULTURE; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; HEART FAILURE; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE; METABOLISM; MIDDLE AGED; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTEIN ANALYSIS; SECRETION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ADULT; ANGIOTENSIN II; ANIMALS; CELLS, CULTURED; CYTOKINES; FEMALE; FIBROBLASTS; HEART FAILURE; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOPROTERENOL; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MIDDLE AGED; MYOCARDIUM; MYOCYTES, CARDIAC; NOREPINEPHRINE; PROTEIN INTERACTION MAPPING; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, SEROTONIN, 5-HT2B; SEROTONIN ANTAGONISTS; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 59649114815     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.180976     Document Type: Article

References (43)

1. Esposito G, Rapacciuolo A, Naga Prasad SV, Takaoka H, Thomas SA, Koch WJ, Rockman HA. Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress. Circulation. 2002;105:85-92.
2. Hill JA, Karimi M, Kutschke W, Davisson RL, Zimmerman K, Wang Z, Kerber RE, Weiss RM. Cardiac hypertrophy is not a required compensatory response to short-term pressure overload. Circulation. 2000;101: 2863-2869.
3. Frey N, Olson EN. Cardiac hypertrophy: the good, the bad, and the ugly. Annu Rev Physiol. 2003;65:45-79.
4. Heineke J, Molkentin JD. Regulation of cardiac hypertrophy by intra-cellular signalling pathways. Nat Rev Mol Cell Biol. 2006;7:589-600.
5. Molkentin JD, Dorn GWn. Cytoplasmic signaling pathways that regulate cardiac hypertrophy. Annu Rev Physiol. 2001;63:391-426.
6. Lohse MJ, Engelhardt S, Eschenhagen T. What is the role of beta-adrenergic signaling in heart failure? Circ Res. 2003;93:896-906.
7. Salazar NC, Chen J, Rockman HA. Cardiac GPCRs: GPCR signaling in healthy and failing hearts. Biochim Biophys Acta. 2007;1768:1006-1018.
8. Kelm M, Schafer S, Mingers S, Heydthausen M, Vogt M, Motz W, Strauer BE. Left ventricular mass is linked to cardiac noradrenaline in normotensive and hypertensive patients. J Hypertens. 1996;14: 1357-1364.
9. Zen K, Irie H, Doue T, Takamiya M, Yamano T, Sawada T, Azuma A, Matsubara H. Analysis of circulating apoptosis mediators and proinflam-matory cytokines in patients with idiopathic hypertrophic cardiomyopa-thy: comparison between nonobstructive and dilated-phase hypertrophic cardiomyopathy. Int Heart J. 2005;46:231-244.
10. Li G, Li RK, Mickle DA, Weisel RD, Merante F, Ball WT, Christakis GT, Cusimano RJ, Williams WG. Elevated insulin-like growth factor-I and transforming growth factor-beta 1 and their receptors in patients with idiopathic hypertrophic obstructive cardiomyopathy. A possible mechanism. Circulation. 1998;98:144-149.
11. Ushikoshi H, Takahashi T, Chen X, Khai NC, Esaki M, Goto K, Takemura G, Maruyama R, Minatoguchi S, Fujiwara T, Nagano S, Yuge K, Kawai T, Murofushi Y, Fujiwara H, Kosai K. Local overexpression of HB-EGF exacerbates remodeling following myocardial infarction by activating noncardiomyocytes. Lab Invest. 2005;85:862-873.
12. Burger A, Benicke M, Deten A, Zimmer HG. Catecholamines stimulate interleukin-6 synthesis in rat cardiac fibroblasts. Am J Physiol Heart Circ Physiol. 2001;281:H14-H21.
13. Jaffré F, Callebert J, Sarre A, Etienne N, Nebigil CG, Launay JM, Maroteaux L, Monassier L. Involvement of the serotonin 5-HT2B receptor in cardiac hypertrophy linked to sympathetic stimulation: control of interleukin-6, interleukin-1 beta, and tumor necrosis factor-alpha cy-tokine production by ventricular fibroblasts. Circulation. 2004;110: 969-974.
14. Sano M, Fukuda K, Kodama H, Pan J, Saito M, Matsuzaki J, Takahashi T, Makino S, Kato T, Ogawa S. Interleukin-6 family of cytokines mediate angiotensin II-induced cardiac hypertrophy in rodent cardiomyocytes. J Biol Chem. 2000;275:29717-29723.
15. Hirota H, Yoshida K, Kishimoto T, Taga T. Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice. Proc Natl Acad Sci U S A. 1995;92:4862-4866.
16. Sivasubramanian N, Coker ML, Kurrelmeyer KM, MacLellan WR, DeMayo FJ, Spinale FG, Mann DL. Left ventricular remodeling in transgenic mice with cardiac restricted overexpression of tumor necrosis factor. Circulation. 2001;104:826-831.
17. Nishikawa K, Yoshida M, Kusuhara M, Ishigami N, Isoda K, Miyazaki K, Ohsuzu F. Left ventricular hypertrophy in mice with a cardiac-specific overexpression of interleukin-1. Am J Physiol Heart Circ Physiol. 2006; 291:H176-H183.
18. Long CS, Hartogensis WE, Simpson PC. Beta-adrenergic stimulation of cardiac non-myocytes augments the growth-promoting activity of non-myocyte conditioned medium. J Mol Cell Cardiol. 1993;25:915-925.
19. Schafer M, Frischkopf K, Taimor G, Piper HM, Schluter KD. Hyper-trophic effect of selective beta(1)-adrenoceptor stimulation on ventricular cardiomyocytes from adult rat. Am J Physiol Cell Physiol. 2000;279: C495-C503.
20. Schluter KD, Piper HM. Trophic effects of catecholamines and parathyroid hormone on adult ventricular cardiomyocytes. Am J Physiol. 1992;263:H1739-H1746.
21. Nebigil CG, Etienne N, Messaddeq N, Maroteaux L. Serotonin is a novel survival factor of cardiomyocytes: mitochondria as a target of 5-HT2B-receptor signaling. FASEB J. 2003;17:1373-1375.
22. Nebigil CG, Jaffré F, Messaddeq N, Hickel P, Monassier L, Launay JM, Maroteaux L. Overexpression of the serotonin 5-HT2B receptor in heart leads to abnormal mitochondrial function and cardiac hypertrophy. Circulation. 2003;107:3223-3229.
23. Nebigil CG, Hickel P, Messaddeq N, Vonesch J-L, Douchet M-P, Monassier L, György K, Martz R, Andriantsitohaina R, Manivet P, Launay J-M, Maroteaux L. Ablation of serotonin 5-HT2B receptors in mice leads to abnormal cardiac structure and function. Circulation. 2001; 103:2973-2979.
24. Monassier L, Laplante MA, Jaffre F, Bousquet P, Maroteaux L, de Champlain J. Serotonin 5-HT2B receptor blockade prevents reactive oxygen species-induced cardiac hypertrophy in mice. Hypertension. 2008;52:301-307.
25. Nebigil CG, Choi D-S, Dierich A, Hickel P, Le Meur M, Messaddeq N, Launay J-M, Maroteaux L. Serotonin 2B receptor is required for heart development. Proc Natl Acad Sci U S A. 2000;97:9508-9513.
26. Landeen LK, Aroonsakool N, Haga JH, Hu BS, Giles WR. Sphingosine-1- phosphate receptor expression in cardiac fibroblasts is modulated by in vitro culture conditions. Am J Physiol Heart Circ Physiol. 2007;292: H2698-H2711.
27. Tanimoto K, Sugiyama F, Goto Y, Ishida J, Takimoto E, Yagami K, Fukamizu A, Murakami K. Angiotensinogen-deficient mice with hypotension. J Biol Chem. 1994;269:31334-31337.
28. Prenzel N, Zwick E, Daub H, Leserer M, Abraham R, Wallasch C, Ullrich A. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature. 1999;402:884-888.
29. Pierce KL, Luttrell LM, Lefkowitz RJ. New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades. Oncogene. 2001;20:1532-1539.
30. Bader M. Role of the local renin-angiotensin system in cardiac damage: a minireview focussing on transgenic animal models. J Mol Cell Cardiol. 2002;34:1455-1462.
31. Dostal DE, Booz GW, Baker KM. Regulation of angiotensinogen gene expression and protein in neonatal rat cardiac fibroblasts by glucocor-ticoid and beta-adrenergic stimulation. Basic Res Cardiol. 2000;95: 485-490.
32. Ohtsu H, Dempsey PJ, Frank GD, Brailoiu E, Higuchi S, Suzuki H, Nakashima H, Eguchi K, Eguchi S. ADAM17 mediates epidermal growth factor receptor transactivation and vascular smooth muscle cell hypertrophy induced by angiotensin II. Arterioscler Thromb Vasc Biol. 2006;26: e133-137.
33. Gooz M, Gooz P, Luttrell LM, Raymond JR. 5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-alpha-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cells. J Biol Chem. 2006;281:21004-21012.
34. Hinkle CL, Sunnarborg SW, Loiselle D, Parker CE, Stevenson M, Russell WE, Lee DC. Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency. J Biol Chem. 2004;279:24179-24188.
35. Pietri M, Schneider B, Mouillet-Richard S, Ermonval M, Mutel V, Launay J-M, Kellermann O. Reactive oxygen species-dependent TNF-alpha converting enzyme activation trough stimulation of 5-HT2B and alpha1D autoreceptors in neuronal cells. FASEB J. 2005;19: 1078-1087.
36. Bulenger S, Marullo S, Bouvier M. Emerging role of homo-and het-erodimerization in G-protein-coupled receptor biosynthesis and maturation. Trends Pharmacol Sci. 2005;26:131-137.
37. Gavarini S, Becamel C, Chanrion B, Bockaert J, Marin P. Molecular and functional characterization of proteins interacting with the C-terminal domains of 5-HT2 receptors: emergence of 5-HT2 "receptosomes". Biol Cell. 2004;96:373-381.
38. Barki-Harrington L, Luttrell LM, Rockman HA. Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo. Circulation. 2003; 108:1611-1618.
39. Thum T, Galuppo P, Wolf C, Fiedler J, Kneitz S, van Laake LW, Doevendans PA, Mummery CL, Borlak J, Haverich A, Gross C, Engelhardt S, Ertl G, Bauersachs J. MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure. Circulation. 2007;116: 258-267.
40. Koyanagi T, Wong LY, Inagaki K, Petrauskene OV, Mochly-Rosen D. Alteration of gene expression during progression of hypertension-induced cardiac dysfunction in rats. Am J Physiol Heart Circ Physiol. 2008;295: H222-H226.
41. Hall JL, Birks EJ, Grindle S, Cullen ME, Barton PJ, Rider JE, Lee S, Harwalker S, Mariash A, Adhikari N, Charles NJ, Felkin LE, Polster S, George RS, Miller LW, Yacoub MH. Molecular signature of recovery following combination left ventricular assist device (LVAD) support and pharmacologic therapy. Eur Heart J. 2007;28:613-627.
42. Brattelid T, Qvigstad E, Birkeland JA, Swift F, Bekkevold SV, Krobert KA, Sejersted OM, Skomedal T, Osnes JB, Levy FO, Sjaastad I. Serotonin responsiveness through 5-HT(2A) and 5-HT(4) receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle. J Mol Cell Cardiol. 2007;43:767-779.
43. Liang YJ, Lai LP, Wang BW, Juang SJ, Chang CM, Leu JG, Shyu KG. Mechanical stress enhances serotonin 2B receptor modulating brain na-triuretic peptide through nuclear factor-kappaB in cardiomyocytes. Car-diovasc Res. 2006;72:303-312.