Serum heat shock protein 70 levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in women with preeclampsia

Clinica Chimica Acta

Volumn 412, Issue 21-22, 2011, Pages 1957-1962

  Molvarec, Attila ^a   Szarka, András ^a   Walentin, Szilvia ^b   Beko, Gabriella ^b   Karádi, István ^b   Prohászka, Zoltán ^b,c   Rigó, János ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Heat shock protein 70; HSPA1A; Inflammation; Preeclampsia; Pregnancy

Indexed keywords

ANGIOGENIC FACTOR; CELL ADHESION MOLECULE; CHEMOKINE; CYTOKINE; FMS LIKE TYROSINE KINASE 1; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; HEAT SHOCK PROTEIN 70; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 12P70; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; PLACENTAL GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; ARTICLE; ASSAY; CASE CONTROL STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ELECTROCHEMILUMINESCENCE IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MULTIPLEX SUSPENSION ASSAY; PATHOGENESIS; PREECLAMPSIA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

ADULT; ANGIOGENIC PROTEINS; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CELL ADHESION MOLECULES; CYTOKINES; FEMALE; HSP70 HEAT-SHOCK PROTEINS; HUMANS; PRE-ECLAMPSIA; PREGNANCY;

EID: 80051704079     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2011.06.042     Document Type: Article

References (40)

1. Redman C.W., Sacks G.P., Sargent I.L. Preeclampsia: an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 1999, 180:499-506.
2. Saito S., Shiozaki A., Nakashima A., Sakai M., Sasaki Y. The role of the immune system in preeclampsia. Mol Aspects Med 2007, 28:192-209.
3. Szarka A., Rigo J., Lazar L., Beko G., Molvarec A. Circulating cytokines, chemokines and adhesion molecules in normal pregnancy and preeclampsia determined by multiplex suspension array. BMC Immunol 2010, 11:59.
4. Maynard S.E., Min J.Y., Merchan J., et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 2003, 111:649-658.
5. Kampinga H.H., Hageman J., Vos M.J., et al. Guidelines for the nomenclature of the human heat shock proteins. Cell Stress Chaperones 2009, 14:105-111.
6. Hightower L.E. Heat shock, stress proteins, chaperones, and proteotoxicity. Cell 1991, 66:191-197.
7. Pockley A.G., Shepherd J., Corton J.M. Detection of heat shock protein 70 (Hsp70) and anti-Hsp70 antibodies in the serum of normal individuals. Immunol Invest 1998, 27:367-377.
8. Molvarec A., Rigo J., Nagy B., et al. Serum heat shock protein 70 levels are decreased in normal human pregnancy. J Reprod Immunol 2007, 74:163-169.
9. Molvarec A., Tamasi L., Losonczy G., Madach K., Prohaszka Z., Rigo J. Circulating heat shock protein 70 (HSPA1A) in normal and pathological pregnancies. Cell Stress Chaperones 2010, 15:237-247.
10. Molvarec A., Prohaszka Z., Nagy B., et al. Association of elevated serum heat-shock protein 70 concentration with transient hypertension of pregnancy, preeclampsia and superimposed preeclampsia: a case-control study. J Hum Hypertens 2006, 20:780-786.
11. Molvarec A., Rigo J., Lazar L., et al. Increased serum heat-shock protein 70 levels reflect systemic inflammation, oxidative stress and hepatocellular injury in preeclampsia. Cell Stress Chaperones 2009, 14:151-159.
12. Molvarec A., Prohaszka Z., Nagy B., et al. Association of increased serum heat shock protein 70 and C-reactive protein concentrations and decreased serum alpha(2)-HS glycoprotein concentration with the syndrome of hemolysis, elevated liver enzymes, and low platelet count. J Reprod Immunol 2007, 73:172-179.
13. Madach K., Molvarec A., Rigo J., et al. Elevated serum 70kDa heat shock protein level reflects tissue damage and disease severity in the syndrome of hemolysis, elevated liver enzymes, and low platelet count. Eur J Obstet Gynecol Reprod Biol 2008, 139:133-138.
14. von Dadelszen P., Magee L.A., Roberts J.M. Subclassification of preeclampsia. Hypertens Pregnancy 2003, 22:143-148.
15. Pockley A.G. Heat shock proteins as regulators of the immune response. Lancet 2003, 362:469-476.
16. Asea A. Stress proteins and initiation of immune response: chaperokine activity of hsp72. Exerc Immunol Rev 2005, 11:34-45.
17. Dybdahl B., Wahba A., Lien E., et al. Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4. Circulation 2002, 105:685-690.
18. Njemini R., Lambert M., Demanet C., Mets T. Elevated serum heat-shock protein 70 levels in patients with acute infection: use of an optimized enzyme-linked immunosorbent assay. Scand J Immunol 2003, 58:664-669.
19. Kimura F., Itoh H., Ambiru S., et al. Circulating heat-shock protein 70 is associated with postoperative infection and organ dysfunction after liver resection. Am J Surg 2004, 187:777-784.
20. Dybdahl B., Slordahl S.A., Waage A., Kierulf P., Espevik T., Sundan A. Myocardial ischaemia and the inflammatory response: release of heat shock protein 70 after myocardial infarction. Heart 2005, 91:299-304.
21. Njemini R., Demanet C., Mets T. Inflammatory status as an important determinant of heat shock protein 70 serum concentrations during aging. Biogerontology 2004, 5:31-38.
22. Njemini R., Bautmans I., Onyema O.O., Van Puyvelde K., Demanet C., Mets T. Circulating heat shock protein 70 in health, aging and disease. BMC Immunol 2011, 12:24.
23. Theriault J.R., Mambula S.S., Sawamura T., Stevenson M.A., Calderwood S.K. Extracellular HSP70 binding to surface receptors present on antigen presenting cells and endothelial/epithelial cells. FEBS Lett 2005, 579:1951-1960.
24. Liu Y., Li N., You L., Liu X., Li H., Wang X. HSP70 is associated with endothelial activation in placental vascular diseases. Mol Med 2008, 14:561-566.
25. Pockley A.G., Calderwood S.K., Multhoff G. The atheroprotective properties of Hsp70: a role for Hsp70-endothelial interactions?. Cell Stress Chaperones 2009, 14:545-553.
26. Prohaszka Z., Fust G. Immunological aspects of heat-shock proteins-the optimum stress of life. Mol Immunol 2004, 41:29-44.
27. Bausero M.A., Gastpar R., Multhoff G., Asea A. Alternative mechanism by which IFN-gamma enhances tumor recognition: active release of heat shock protein 72. J Immunol 2005, 175:2900-2912.
28. Njemini R., Lambert M., Demanet C., Vanden Abeele M., Vandebosch S., Mets T. The induction of heat shock protein 70 in peripheral mononuclear blood cells in elderly patients: a role for inflammatory markers. Hum Immunol 2003, 64:575-585.
29. Kingston A.E., Hicks C.A., Colston M.J., Billingham M.E. A 71-kD heat shock protein (hsp) from Mycobacterium tuberculosis has modulatory effects on experimental rat arthritis. Clin Exp Immunol 1996, 103:77-82.
30. Tanaka S., Kimura Y., Mitani A., et al. Activation of T cells recognizing an epitope of heat-shock protein 70 can protect against rat adjuvant arthritis. J Immunol 1999, 163:5560-5565.
31. Cooper A.M., Khader S.A. IL-12p40: an inherently agonistic cytokine. Trends Immunol 2007, 28:33-38.
32. Saito S. Th17 cells and regulatory T cells: new light on pathophysiology of preeclampsia. Immunol Cell Biol 2010, 88:615-617.
33. Jirecek S., Hohlagschwandtner M., Tempfer C., Knofler M., Husslein P., Zeisler H. Serum levels of heat shock protein 70 in patients with preeclampsia: a pilot-study. Wien Klin Wochenschr 2002, 114:730-732.
34. Fukushima A., Kawahara H., Isurugi C., et al. Changes in serum levels of heat shock protein 70 in preterm delivery and pre-eclampsia. J Obstet Gynaecol Res 2005, 31:72-77.
35. Hunter-Lavin C., Davies E.L., Bacelar M.M., Marshall M.J., Andrew S.M., Williams J.H. Hsp70 release from peripheral blood mononuclear cells. Biochem Biophys Res Commun 2004, 324:511-517.
36. Boutet M., Roland L., Thomas N., Bilodeau J.F. Specific systemic antioxidant response to preeclampsia in late pregnancy: the study of intracellular glutathione peroxidases in maternal and fetal blood. Am J Obstet Gynecol 2009, 200(530):e1-e7.
37. Padmini E., Lavanya S., Uthra V. Preeclamptic placental stress and over expression of mitochondrial HSP70. Clin Chem Lab Med 2009, 47:1073-1080.
38. Barut F., Barut A., Dogan Gun B., et al. Expression of heat shock protein 70 and endothelial nitric oxide synthase in placental tissue of preeclamptic and intrauterine growth-restricted pregnancies. Pathol Res Pract 2010, 206:651-656.
39. Roland-Zejly L., Moisan V., St-Pierre I., Bilodeau J.F. Altered placental glutathione peroxidase mRNA expression in preeclampsia according to the presence or absence of labor. Placenta 2011, 32:161-167.
40. Futagami S., Hiratsuka T., Shindo T., et al. Extracellular HSP70 blocks CD40L-induced apoptosis and tubular formation in endothelial cells. J Gastroenterol Hepatol 2008, 23(Suppl. 2):S222-S228.