Effects of estradiol and progesterone on the proinflammatory cytokine production by mononuclear cells from patients withchronic hepatitis C

World Journal of Gastroenterology

Volumn 14, Issue 14, 2008, Pages 2200-2207

  Yuan, Ying ^a   Shimizu, Ichiro ^b   Shen, Mi ^a   Aoyagi, Eriko ^b   Takenaka, Hidetaka ^b   Itagaki, Tatuzo ^b   Urata, Mari ^b   Sannomiya, Katsutaka ^b   Kohno, Nao ^b   Tamaki, Katsuyoshi ^b   Shono, Masayuki ^c   Takayama, Tetsuji ^b  

^a NANTONG UNIVERSITY   (China)

^b Institute of Health Biosciences   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Chemokine; Estradiol; Mononuclear cell; Progesterone; Proinflammatory cytokine

Indexed keywords

CYTOKINE; ESTRADIOL; HYDROGEN PEROXIDE; INTERLEUKIN 1BETA; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; PROGESTERONE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATITIS C; HORMONE ACTION; HUMAN; HUMAN CELL; LIVER INJURY; MACROPHAGE ACTIVATION; MAJOR CLINICAL STUDY; MALE; OXIDATIVE STRESS; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN ANALYSIS; PROTEIN SYNTHESIS INHIBITION; AGED; BIOLOGICAL MODEL; BLOOD; CASE CONTROL STUDY; INFLAMMATION; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; POSTMENOPAUSE; PREMENOPAUSE;

AGED; CASE-CONTROL STUDIES; CYTOKINES; ESTRADIOL; FEMALE; HEPATITIS C, CHRONIC; HUMANS; INFLAMMATION; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; POSTMENOPAUSE; PREMENOPAUSE; PROGESTERONE;

EID: 49249098011     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.14.2200     Document Type: Article

References (30)

1. McMahon BJ, Alberts SR, Wainwright RB, Bulkow L, Lanier AP. Hepatitis B-related sequelae. Prospective study in 1400 hepatitis B surface antigen-positive Alaska native carriers. Arch Intern Med 1990; 150: 1051-1054
2. Poynard T, Ratziu V, Charlotte F, Goodman Z, McHutchison J, Albrecht J. Rates and risk factors of liver fibrosis progression in patients with chronic hepatitis c. J Hepatol 2001; 34: 730-739
3. Pfeilschifter J, Koditz R, Pfohl M, Schatz H. Changes in proinflammatory cytokine activity after menopause. Endocr Rev 2002; 23: 90-119
4. Pinkus R, Weiner LM, Daniel V. Role of oxidants and antioxidants in the induction of AP-1, NF-kappaB, and glutathione S-transferase gene expression. J Biol Chem 1996; 271: 13422-13429
5. Omoya T, Shimizu I, Zhou Y, Okamura Y, Inoue H, Lu G, Itonaga M, Honda H, Nomura M, Ito S. Effects of idoxifene and estradiol on NF-kappaB activation in cultured rat hepatocytes undergoing oxidative stress. Liver 2001; 21: 183-191
6. Inoue H, Shimizu I, Lu G, Itonaga M, Cui X, Okamura Y, Shono M, Honda H, Inoue S, Muramatsu M, Ito S. Idoxifene and estradiol enhance antiapoptotic activity through estrogen receptor-beta in cultured rat hepatocytes. Dig Dis Sci 2003; 48: 570-580
7. Shimizu I. Impact of oestrogens on the progression of liver disease. Liver Int 2003; 23: 63-69
8. Shimizu I, Kohno N, Tamaki K, Shono M, Huang HW, He JH, Yao DF. Female hepatology: favorable role of estrogen in chronic liver disease with hepatitis B virus infection. World J Gastroenterol 2007; 13: 4295-4305
9. Bouman A, Heineman MJ, Faas MM. Sex hormones and the immune response in humans. Hum Reprod Update 2005; 11: 411-423
10. Rojkind M, Dominguez-Rosales JA, Nieto N, Greenwel P. Role of hydrogen peroxide and oxidative stress in healing responses. Cell Mol Life Sci 2002; 59: 1872-1891
11. Karasu Z, Tekin F, Ersoz G, Gunsar F, Batur Y, Ilter T, Akarca US. Liver fibrosis is associated with decreased peripheral platelet count in patients with chronic hepatitis B and C. Dig Dis Sci 2007; 57: 1535-1539
12. Rogers A, Eastell R. The effect of 17beta-estradiol on production of cytokines in cultures of peripheral blood. Bone 2001; 29: 30-34
13. Rachon D, Mysliwska J, Suchecka-Rachon K, Wieckiewicz J, Mysliwski A. Effects of oestrogen deprivation on interleukin-6 production by peripheral blood mononuclear cells of postmenopausal women. J Endocrinol 2002; 172: 387-395
14. Kishihara Y, Hayashi J, Yoshimura E, Yamaji K, Nakashima K, Kashiwagi S. IL-1 beta and TNF-alpha produced by peripheral blood mononuclear cells before and during interferon therapy in patients with chronic hepatitis C. Dig Dis Sci 1996; 41: 315-321
15. Huang H, He J, Yuan Y, Aoyagi E, Takenaka H, Itagaki T, Sannomiya K, Tamaki K, Harada N, Shono M, Shimizu I, Takayama T. Opposing effects of estradiol and progesterone on the oxidative stress-induced production of chemokine and proinflammatory cytokines in murine peritoneal macrophages. J Med Invest 2008; 55: 133-141
16. Kilbourne EJ, Scicchitano MS. The activation of plasminogen activator inhibitor-1 expression by IL-1beta is attenuated by estrogen in hepatoblastoma HepG2 cells expressing estrogen receptor alpha. Thromb Haemost 1999; 81: 423-427
17. Ozveri ES, Bozkurt A, Haklar G, Cetinel S, Arbak S, Yegen C, Yegen BC. Estrogens ameliorate remote organ inflammation induced by burn injury in rats. Inflamm Res 2001; 50: 585-591
18. Loy RA, Loukides JA, Polan ML. Ovarian steroids modulate human monocyte tumor necrosis factor alpha messenger ribonucleic acid levels in cultured human peripheral monocytes. Fertil Steril 1992; 58: 733-739
19. Konecna L, Yan MS, Miller LE, Scholmerich J, Falk W, Straub RH. Modulation of IL-6 production during the menstrual cycle in vivo and in vitro. Brain Behav Immun 2000; 14: 49-61
20. Schwarz E, Schafer C, Bode JC, Bode C. Influence of the menstrual cycle on the LPS-indwed cytokine response of monocytes. Cytokine 2000; 12: 413-416
21. Bouman A, Schipper M, Heineman MJ, Faas M. 17beta-estradiol and progesterone do not influence the production of cytokines from lipopolysaccharide-stimulated monocytes in humans. Fertil Steril 2004; 82 Suppl 3: 1212-1219
22. Ralston SH, Russell RG, Gowen M. Estrogen inhibits release of tumor necrosis factor from peripheral blood mononuclear cells in postmenopausal women. J Bone Miner Res 1990; 5: 983-988
23. Morishita M, Miyagi M, Iwamoto Y. Effects of sex hormones on production of interleukin-1 by human peripheral monocytes. J Periodontol 1999; 70: 757-760
24. Brannstrom M, Friden BE, Jasper M, Norman RJ. Variations in peripheral blood levels of immunoreactive tumor necrosis factor alpha (TNFalpha) throughout the menstrual cycle and secretion of TNFalpha from the human corpus luteum. Eur J Obstet Gynecol Reprod Biol 1999; 83: 213-217
25. Cheng X, Shimizu I, Yuan Y, Wei M, Shen M, Huang H, Urata M, Sannomiya K, Fukuno, H, Hashimoto-Tamaoki T, Ito S. Effects of estradiol and progesterone on tumor necrosis factor alpha-induced apoptosis in human hepatoma HuH-7 cells. Life Sci 2006; 79: 1988-1994
26. Takano S, Yokosuka O, Imazeki F, Tagawa M, Omata M. Incidence of hepatocelluIar carcinoma in chronic hepatitis B and C: a prospective study of 251 patients. Hepatology 1995; 21: 650-655
27. Shiratori Y, Shiina S, Imamura M, Kato N, Kanai F, Okudaira T, Teratani T, Tohgo G, Toda N, Ohashi M. Characteristic difference of hepatocellular carcinoma between hepatitis B- and C-viral infection in Japan. Hepatology 1995; 22: 1027-1033
28. You LR, Chen CM, Lee YH. Hepatitis C virus core protein enhances NF-kappaB signal pathway triggering by lymphotoxin-beta receptor ligand and tumor necrosis factor alpha. J Virol 1999; 73: 1672-1681
29. Shimizu I, Ito S. Protection of estrogens against the progression of chronic liver disease. Hepatol Res 2007; 37: 239-247
30. Itagaki T, Shimizu I, Cheng X, Yuan Y, Oshio A, Tamaki K, Fukuno H, Honda H, Okamura Y, Ito S. Opposing effects of oestradiol and progesterone on intracellular pathways and activation processes in the oxidative stress induced activation of cultured rat hepatic stellate cells. Gut 2005; 54: 1782-1789