Two Variants of the C-Reactive Protein Gene Are Associated with Risk of Pre-Eclampsia in an American Indian Population

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Best, Lyle G ^a,b   Saxena, Richa ^c   Anderson, Cindy M ^d   Barnes, Michael R ^e   Hakonarson, Hakon ^f   Falcon, Gilbert ^a   Martin, Candelaria ^a   Castillo, Berta Almoguera ^f   Karumanchi, Ananth ^g   Keplin, Kylie ^a   Pearson, Nichole ^a   Lamb, Felicia ^a   Bercier, Shellee ^a   Keating, Brendan J ^f  

^a Turtle Mountain Community College   (United States)

^b UNIVERSITY OF NORTH DAKOTA SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF NORTH DAKOTA   (United States)

^e QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^f CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^g HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN;

ADULT; AMERICAN INDIAN; ARTICLE; BODY MASS; C REACTIVE PROTEIN GENE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MATERNAL AGE; NULLIPARA; PREECLAMPSIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INDIANS, NORTH AMERICAN; POLYMORPHISM, SINGLE NUCLEOTIDE; PRE-ECLAMPSIA; PREGNANCY; RISK FACTORS; YOUNG ADULT;

EID: 84881150671     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071231     Document Type: Article

References (65)

1. Young BC, Levine RJ, Karumanchi SA, (2010) Pathogenesis of preeclampsia. Annu Rev Pathol 5: 173-192 10.1146/annurev-pathol-121808-102149.
2. Lindheimer MD, Taler SJ, Cunningham FG, (2010) Hypertension in pregnancy. J Am Soc Hypertens 4: 68-78 10.1016/j.jash.2010.03.002.
3. Mignini LE, Villar J, Khan KS, (2006) Mapping the theories of preeclampsia: The need for systematic reviews of mechanisms of the disease. Am J Obstet Gynecol 194: 317-321 10.1016/j.ajog.2005.08.065.
4. Livingston JC, Maxwell BD, (2003) Preeclampsia: Theories and speculations. Wien Klin Wochenschr 115: 145-8.
5. Baumwell S, Karumanchi SA, (2007) Pre-eclampsia: Clinical manifestations and molecular mechanisms. Nephron Clin Pract 106: c72-81.
6. Maynard S, Epstein FH, Karumanchi SA, (2008) Preeclampsia and angiogenic imbalance. Annu Rev Med 59: 61-78 10.1146/annurev.med.59.110106.214058.
7. Sibai B, Dekker G, Kupferminc M, (2005) Pre-eclampsia. Lancet 365: 785-99.
8. Visser N, van Rijn BB, Rijkers GT, Franx A, Bruinse HW, (2007) Inflammatory changes in preeclampsia: Current understanding of the maternal innate and adaptive immune response. Obstet Gynecol Surv 62: 191-201 10.1097/01.ogx.0000256779.06275.c4.
9. Chesley LC, Annitto JE, Cosgrove RA, (1968) The familial factor in toxemia of pregnancy. Obstet Gynecol 32: 303-311.
10. Sutherland A, Cooper DW, Howie PW, Liston WA, MacGillivray I, (1981) The incidence of severe pre-eclampsia amongst mothers and mothers-in-law of pre-eclamptics and controls. Br J Obstet Gynaecol 88: 785-791.
11. Arngrimsson R, Bjornsson S, Geirsson RT, Bjornsson H, Walker JJ, et al. (1990) Genetic and familial predisposition to eclampsia and pre-eclampsia in a defined population. Br J Obstet Gynaecol 97: 762-769.
12. Lie RT, Rasmussen S, Brunborg H, Gjessing HK, Lie-Nielsen E, et al. (1998) Fetal and maternal contributions to risk of pre-eclampsia: Population based study. BMJ 316: 1343-1347.
13. Nilsson E, Salonen Ros H, Cnattingius S, Lichtenstein P, (2004) The importance of genetic and environmental effects for pre-eclampsia and gestational hypertension: A family study. BJOG 111: 200-206.
14. Cnattingius S, Reilly M, Pawitan Y, Lichtenstein P, (2004) Maternal and fetal genetic factors account for most of familial aggregation of preeclampsia: A population-based swedish cohort study. Am J Med Genet A 130: 365-71.
15. Folgero T, Storbakk N, Torbergsen T, Oian P, (1996) Mutations in mitochondrial transfer ribonucleic acid genes in preeclampsia. Am J Obstet Gynecol 174: 1626-1630.
16. Arngrimsson R, Siguroardottir S, Frigge ML, Bjarnadottir RI, Jonsson T, et al. (1999) A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13. Hum Mol Genet 8: 1799-1805.
17. Moses EK, Lade JA, Guo G, Wilton AN, Grehan M, et al. (2000) A genome scan in families from Australia and New Zealand confirms the presence of a maternal susceptibility locus for pre-eclampsia, on chromosome 2. Am J Hum Genet 67: 1581-1585 10.1086/316888.
18. Laivuori H, Lahermo P, Ollikainen V, Widen E, Haiva-Mallinen L, et al. (2003) Susceptibility loci for preeclampsia on chromosomes 2p25 and 9p13 in Finnish families. Am J Hum Genet 72: 168-177 10.1086/345311.
19. Roten LT, Johnson MP, Forsmo S, Fitzpatrick E, Dyer TD, et al. (2009) Association between the candidate susceptibility gene ACVR2A on chromosome 2q22 and pre-eclampsia in a large Norwegian population-based study (the HUNT study). Eur J Hum Genet 17: 250-257 10.1038/ejhg.2008.158; 10.1038/ejhg.2008.158.
20. Johnson MP, Roten LT, Dyer TD, East CE, Forsmo S, et al. (2009) The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations. Hum Genet 126: 655-666 10.1007/s00439-009-0714-x.
21. Founds SA, Conley YP, Lyons-Weiler JF, Jeyabalan A, Hogge WA, et al. (2009) Altered global gene expression in first trimester placentas of women destined to develop preeclampsia. Placenta 30: 15-24 10.1016/j.placenta.2008.09.015.
22. Ilekis JV, Reddy UM, Roberts JM, (2007) Preeclampsia-a pressing problem: An executive summary of a National Institute of Child Health and Human Development workshop. Reprod Sci 14: 508-523 10.1177/1933719107306232.
23. Levy MT, Jacober SJ, Sowers JR, (1994) Hypertensive disorders of pregnancy in Southwestern Navajo Indians. Arch Intern Med 154: 2181-2183.
24. Tanaka M, Jaamaa G, Kaiser M, Hills E, Soim A, et al. (2007) Racial disparity in hypertensive disorders of pregnancy in New York State: A 10-year longitudinal population-based study. Am J Public Health 97: 163-170 10.2105/AJPH.2005.068577.
25. Du Clos TW, Mold C, (2004) C-reactive protein: An activator of innate immunity and a modulator of adaptive immunity. Immunol Res 30: 261-277 10.1385/IR:30:3:261.
26. Blake GJ, Ridker PM, (2002) Inflammatory bio-markers and cardiovascular risk prediction. J Intern Med 252: 283-294.
27. Thilaganathan B, Wormald B, Zanardini C, Sheldon J, Ralph E, et al. (2010) Early-pregnancy multiple serum markers and second-trimester uterine artery doppler in predicting preeclampsia. Obstet Gynecol 115: 1233-1238 10.1097/AOG.0b013e3181dd5137.
28. Cebesoy FB, Balat O, Dikensoy E, Kalayci H, Ibar Y, (2009) CA-125 and CRP are elevated in preeclampsia. Hypertens Pregnancy 28: 201-211 10.1080/10641950802601187.
29. Guven MA, Coskun A, Ertas IE, Aral M, Zencirci B, et al. (2009) Association of maternal serum CRP, IL-6, TNF-alpha, homocysteine, folic acid and vitamin B12 levels with the severity of preeclampsia and fetal birth weight. Hypertens Pregnancy 28: 190-200 10.1080/10641950802601179.
30. Sesso HD, Buring JE, Rifai N, Blake GJ, Gaziano JM, et al. (2003) C-reactive protein and the risk of developing hypertension. JAMA 290: 2945-2951 10.1001/jama.290.22.2945.
31. Best LG, Nadeau M, Davis K, Lamb F, Bercier S, et al. (2012) Genetic variants, immune function, and risk of pre-eclampsia among American Indians. Am J Reprod Immunol 67: 152-159 10.1111/j.1600-0897.2011.01076.x; 10.1111/j.1600-0897.2011.01076.x.
32. U.S. Department of Health and Human Services, National Institute of Health, National Heart, Lung and Blood Institute (2000) Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol 183: S1-S22.
33. Lindheimer MD, Taler SJ, Cunningham FG, (2009) American Society of Hypertension (2009) ASH position paper: Hypertension in pregnancy. J Clin Hypertens (Greenwich) 11: 214-225 10.1111/j.1751-7176.2009.00085.x; 10.1111/j.1751-7176.2009.00085.x.
34. Bodnar LM, Catov JM, Roberts JM (2007) Racial/ethnic differences in the monthly variation of preeclampsia incidence. Am J Obstet Gynecol 196324 e1-5.
35. Keating BJ, Tischfield S, Murray SS, Bhangale T, Price TS, et al. (2008) Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One 3: e3583 10.1371/journal.pone.0003583; 10.1371/journal.pone.0003583.
36. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, et al. (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38: 904-909 10.1038/ng1847.
37. Genomes Project Consortium (2010) Abecasis GR, Altshuler D, Auton A, Brooks LD, et al. (2010) A map of human genome variation from population-scale sequencing. Nature 467: 1061-1073 10.1038/nature09534; 10.1038/nature09534.
38. Ward LD, Kellis M, (2012) HaploReg: A resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res 40: D930-4 10.1093/nar/gkr917; 10.1093/nar/gkr917.
39. Boyle AP, Hong EL, Hariharan M, Cheng Y, Schaub MA, et al. (2012) Annotation of functional variation in personal genomes using Regulomedb. Genome Res 22: 1790-1797 10.1101/gr.137323.112; 10.1101/gr.137323.112.
40. ENCODE Project Consortium (2012) Dunham I, Kundaje A, Aldred SF, Collins PJ, et al. (2012) An integrated encyclopedia of DNA elements in the human genome. Nature 489: 57-74 10.1038/nature11247; 10.1038/nature11247.
41. ACOG Committee on Obstetric Practice (2002) ACOG practice bulletin. diagnosis and management of preeclampsia and eclampsia. number 33, January 2002. American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet 77: 67-75.
42. Choi YS, Hur J, Jeong S, (2007) Beta-catenin binds to the downstream region and regulates the expression C-reactive protein gene. Nucleic Acids Res 35: 5511-5519 10.1093/nar/gkm547.
43. Kestlerova A, Feyereisl J, Frisova V, Mechurova A, Sula K, et al. (2012) Immunological and biochemical markers in preeclampsia. J Reprod Immunol 96: 90-94 10.1016/j.jri.2012.10.002; 10.1016/j.jri.2012.10.002.
44. Derzsy Z, Prohaszka Z, Rigo J Jr, Fust G, Molvarec A, (2010) Activation of the complement system in normal pregnancy and preeclampsia. Mol Immunol 47: 1500-1506 10.1016/j.molimm.2010.01.021.
45. Gandevani SB, Banaem LM, Mohamadi B, Moghadam NA, Asghari M, (2012) Association of high-sensitivity C-reactive protein serum levels in early pregnancy with the severity of preeclampsia and fetal birth weight. J Perinat Med 0: 1-5 10.1515/jpm-2011-0190; 10.1515/jpm-2011-0190.
46. Rebelo F, Schlussel MM, Vaz JS, Franco-Sena AB, Pinto TJ,et al. (2012) C-reactive protein and later preeclampsia: Systematic review and meta-analysis taking into account the weight status. J Hypertens. 10.1097/HJH.0b013e32835b0556.
47. Emerging Risk Factors Collaboration (2012) Kaptoge S, Di Angelantonio E, Pennells L, Wood AM, et al. (2012) C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med 367: 1310-1320 10.1056/NEJMoa1107477; 10.1056/NEJMoa1107477.
48. Dehghan A, Dupuis J, Barbalic M, Bis JC, Eiriksdottir G, et al. (2011) Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation 123: 731-738 10.1161/CIRCULATIONAHA.110.948570.
49. Carlson CS, Aldred SF, Lee PK, Tracy RP, Schwartz SM, et al. (2005) Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels. Am J Hum Genet 77: 64-77 10.1086/431366.
50. Benjamin EJ, Dupuis J, Larson MG, Lunetta KL, Booth SL, et al. (2007) Genome-wide association with select biomarker traits in the Framingham Heart Study. BMC Med Genet 8Suppl 1: S11 10.1186/1471-2350-8-S1-S11.
51. National Center for Biotechnology Information (NCBI) dbSNP Short Genetic Variations rs3093068, http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=3093068. Accessed 2013 July 5.
52. Lee CC, You NC, Song Y, Hsu YH, Manson J, et al. (2009) Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: Findings from the Women's Health Initiative observational cohort. Clin Chem 55: 351-360 10.1373/clinchem.2008.117176.
53. Kardys I, de Maat MP, Klaver CC, Despriet DD, Uitterlinden AG, et al. (2007) Usefulness of combining complement factor H and C-reactive protein genetic profiles for predicting myocardial infarction (from the rotterdam study). Am J Cardiol 100: 646-648 10.1016/j.amjcard.2007.03.079.
54. Kim IK, Ji F, Morrison MA, Adams S, Zhang Q, et al. (2008) Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration. Mol Vis 14: 1487-1495.
55. [National Center for Biotechnology Information (NCBI) dbSNP Short Genetic Variations rs876538 http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=876538, Accessed 2013, July 5.
56. Perry TE, Muehlschlegel JD, Liu KY, Fox AA, Collard CD, et al. (2009) C-reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery. BMC Med Genet 10: 38 10.1186/1471-2350-10-38.
57. eQTL resources@the pritchard lab. http://eqtl.uchicago.edu/cgi-bin/gbrowse/eqtl/ Accessed 2013, July 5.
58. Feng X, Xiao J, Longville B, Tan AX, Wu XN, et al. (2009) Complement factor H Y402H and C-reactive protein polymorphism and photodynamic therapy response in age-related macular degeneration. Ophthalmology 116: 1908-12.e1 10.1016/j.ophtha.2009.03.011.
59. Best LG, North KE, Tracy RP, Lee ET, Howard BV, et al. (2004) Genetic determination of acute phase reactant levels: The Strong Heart Study. Hum Hered 58: 112-116 10.1159/000083032.
60. Kathiresan S, Larson MG, Vasan RS, Guo CY, Gona P, et al. (2006) Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level. Circulation 113: 1415-1423 10.1161/CIRCULATIONAHA.105.591271.
61. Paternoster DM, Fantinato S, Stella A, Nanhorngue KN, Milani M, et al. (2006) C-reactive protein in hypertensive disorders in pregnancy. Clin Appl Thromb Hemost 12: 330-337 10.1177/1076029606291382.
62. Kucukgoz Gulec U, Tuncay Ozgunen F, Baris Guzel A, Buyukkurt S, Seydaoglu G, et al. (2012) An analysis of C-reactive protein, procalcitonin, and D-dimer in pre-eclamptic patients. Am J Reprod Immunol 68: 331-337 10.1111/j.1600-0897.2012.01171.x; 10.1111/j.1600-0897.2012.01171.x.
63. Gammill HS, Powers RW, Clifton RG, Van Dorsten JP, Klebanoff MA, et al. (2010) Does C-reactive protein predict recurrent preeclampsia? Hypertens Pregnancy 29: 399-409 10.3109/10641950903214633; 10.3109/10641950903214633.
64. Qiu C, Luthy DA, Zhang C, Walsh SW, Leisenring WM, et al. (2004) A prospective study of maternal serum C-reactive protein concentrations and risk of preeclampsia. Am J Hypertens 17: 154-160.
65. Salihu HM, De La Cruz C, Rahman S, August EM, (2012) Does maternal obesity cause preeclampsia? A systematic review of the evidence. Minerva Ginecol 64: 259-280.