Known and emerging factors modulating estrogenic effects of endocrine-disrupting chemicals

Environmental Reviews

Volumn 22, Issue 1, 2014, Pages 87-98

  Zhang, Wanglong ^a   Luo, Yu ^a   Zhang, Li ^a   Cai, Qian ^a   Pan, Xuejun ^a  

^a KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Estrogenic effects; Genomic effects; Nongenomic effects; Xenoestrogen

Indexed keywords

ENDOCRINE DISRUPTING CHEMICALS; ESTROGENIC EFFECT; GENOMIC EFFECTS; NONGENOMIC EFFECTS; PHYSIOLOGICAL RESPONSE; POST-TRANSLATIONAL MODIFICATIONS; SIGNALING MOLECULES; XENOESTROGEN;

PROTEINS;

GENES;

EID: 84897675400     PISSN: 11818700     EISSN: None     Source Type: Journal    
DOI: 10.1139/er-2013-0047     Document Type: Review

References (141)

1. Acconcia F. Ascenzi P. Bocedi A. Spisni E. Tomasi V. Trentalance A. Visca P. Marino M. 2005. Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol. Mol. Biol. Cell 16 (1): 231-237. 10.1091/mbc.E04-07-0547.539167. (Pubitemid 40028339)
2. Acconcia F. Kumar R. 2006. Signaling regulation of genomic and nongenomic functions of estrogen receptors. Cancer Lett. 238 (1): 1-14. 10.1016/j.canlet.2005.06.018. 16084012. (Pubitemid 43851144)
3. Ahmed S. Valen E. Sandelin A. Matthews J. 2009. Dioxin Increases the Interaction Between Aryl Hydrocarbon Receptor and Estrogen Receptor Alpha at Human Promoters. Toxicol. Sci. 111 (2): 254-266. 10.1093/toxsci/kfp144. 19574409.
4. Albanito L. Madeo A. Lappano R. Vivacqua A. Rago V. Carpino A. Oprea T.I. Prossnitz E.R. Musti A.M. Ando S. Maggiolini M. 2007. G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells. Cancer Res. 67 (4): 1859-1866. 10.1158/0008-5472.CAN-06-2909. 17308128. (Pubitemid 46383413)
5. Ali S. Metzger D. Bornert J.M. Chambon P. 1993. Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region. Embo J. 12 (3): 1153-1160. 8458328. (Pubitemid 23095864)
6. Anderson R.G.W. 1998. The caveolae membrane system. Annu. Rev. Biochem. 67: 199-225. 10.1146/annurev.biochem.67.1.199. 9759488. (Pubitemid 28411129)
7. Anstead G.M. Carlson K.E. Katzenellenbogen J.A. 1997. The estradiol pharmacophore: ligand structure-estrogen receptor binding affinity relationships and a model for the receptor binding site. Steroids, 62 (3): 268-303. 10.1016/S0039-128X(96)00242-5. 9071738. (Pubitemid 27114399)
8. Arukwe A. 2001. Cellular and molecular responses to endocrine-modulators and the impact on fish reproduction. Mar. Pollut. Bull. 42 (8): 643-655. 10.1016/S0025-326x(01)00062-5. 11525282.
9. Arukwe A. 2005. Modulation of brain steroidogenesis by affecting transcriptional changes of steroidogenic acute regulatory (StAR) protein and cholesterol side chain cleavage (P450scc) in juvenile Atlantic salmon (Salmo salar) is a novel aspect of nonylphenol toxicity. Environ. Sci. Technol. 39 (24): 9791-9798. 10.1021/es0509937. 16475368. (Pubitemid 41832163)
10. Arukwe A. 2008. Steroidogenic acute regulatory (StAR) protein and cholesterol side-chain cleavage (P450scc)-regulated steroidogenesis as an organ-specific molecular and cellular target for endocrine disrupting chemicals in fish. Cell Biol. Toxicol. 24 (6): 527-540. 10.1007/s10565-008-9069-7. 18398688.
11. Ascenzi P. Bocedi A. Marino M. 2006. Structure-function relationship of estrogen receptor alpha and beta: impact on human health. Mol. Asp. Med. 27 (4): 299-402. 10.1016/j.mam.2006.07.001. (Pubitemid 44255847)
12. Azuma K. Horie K. Inoue S. Ouchi Y. Sakai R. 2004. Analysis of estrogen receptor alpha signaling complex at the plasma membrane. FEBS Lett. 577 (3): 339-344. 10.1016/j.febslet.2004.10.025. 15556606. (Pubitemid 39535310)
13. Bang D.Y. Kyung M. Kim M.J. Jung B.Y. Cho M.C. Choi S.M. Kim Y.W. et al 2012. Human Risk Assessment of Endocrine-Disrupting Chemicals Derived from Plastic Food Containers. Compr. Rev. Food. Sci. Food Saf. 5 (11): 453-470. 10.1111/j.1541-4337.2012.00197.x.
14. Bergman, Å., Heindel, J.J., Jobling, S., Kidd, K.A., Zoeller, R.T. 2013. Executive summary. in State of the Science of Endocrine Disrupting Chemicals-2012: An assessment of the state of the science of endocrine disruptors prepared by a group of experts for the United Nations Environment Programme and World Health Organization. WHO press. ISBN:978 92 4 150503 1
15. Boonyaratanakornkit V. 2011. Scaffolding proteins mediating membrane-initiated extra-nuclear actions of estrogen receptor. Steroids, 76 (9): 877-884. 10.1016/j.steroids.2011.02.017. 21354435.
16. Bouskine A. Nebout M. Brucker-Davis F. Benahmed M. Fenichel P. 2009. Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrogen receptor. Environ. Health Perspect. 117 (7): 1053-1058. 10.1289/ehp.0800367.2717129. 19654912.
17. Boverhof D.R. Kwekel J.C. Humes D.G. Burgoon L.D. Zacharewski T.R. 2006. Dioxin induces an estrogen-like, estrogen receptor-dependent gene expression response in the murine uterus. Mol. Pharmacol. 69 (5): 1599-1606. 10.1124/mol.105.019638. 16467188.
18. Brzozowski A.M. Pike A.C. Dauter Z. Hubbard R.E. Bonn T. Engstrom O. Ohman L. et al 1997. Molecular Basis of Agonism and Antagonism in the Oestrogen Receptor. Nature, 389 (6652): 753-758. 10.1038/39645. 9338790. (Pubitemid 27458965)
19. Cai J.L. Wang C.G. Wu T. Moreno J.M.L. Zhong Y.F. Huang X. Chen Y.X. Zuo Z.H. 2011. Disruption of spermatogenesis and differential regulation of testicular estrogen receptor expression in mice after polychlorinated biphenyl exposure. Toxicology, 287 (1-3): 21-28. 10.1016/j.tox.2011.05.010. 21664404.
20. Caplan A.J. Tsai J. Casey P.J. Douglas M.G. 1992. Farnesylation of Ydj1p Is Required for Function at Elevated Growth Temperatures in Saccharomyces Cerevisiae. J. Biol. Chem. 267 (26): 18890-18895. 1527016.
21. Carlson D.B. Perdew G.H. 2002. A dynamic role for the Ah receptor in cell signaling? Insights from a diverse group of ah receptor interacting proteins. J. Biochem. Mol. Toxicol. 16 (6): 317-325. 10.1002/Jbt.10051. (Pubitemid 36104173)
22. Carroll J.S. Liu X.S. Brodsky A.S. Li W. Meyer C.A. Szary A.J. Eeckhoute J. Shao W.L. Hestermann E.V. Geistlinger T.R. Fox E.A. Silver P.A. Brown M. 2005. Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell, 122 (1): 33-43. 10.1016/j.cell.2005.05.008. 16009131. (Pubitemid 40977938)
23. Chaffin C.L. Peterson R.E. Hutz R.J. 1996. In utero and lactational exposure of female Holtzman rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin: modulation of the estrogen signal. Biol. Reprod. 55 (1): 62-67. 10.1095/biolreprod55.1.62. 8793059. (Pubitemid 26293141)
24. Cheshenko K. Pakdel F. Segner H. Kah O. Eggen R.I.L. 2008. Interference of endocrine disrupting chemicals with aromatase CYP19 expression or activity, and consequences for reproduction of teleost fish. Gen. Comp. Endocrinol. 155 (1): 31-62. 10.1016/j.ygeen.2007.03.005. 17459383. (Pubitemid 350122476)
25. Deblois G. Giguere V. 2003. Ligand-independent coactivation of ER alpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation. J. Steroid Biochem. Mol. Biol. 85 (2-5): 123-131. 10.1016/S0960-0760(03)00225-5. 12943696. (Pubitemid 37020884)
26. Delfosse V. Grimaldi M. Pons J.L. Boulahtouf A. Maire A.L. Cavailles V. Labesse G. Bourguet W. Balaguer P. 2012. Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes. Proc. Natl. Acad. Sci. U. S. A. 109 (37): 14930-14935. 10.1073/pnas.1203574109. 22927406.
27. Deng H. Huang X. Fan J. Wang L. Xia Q. Yang X. Wang Z. Liu L. 2010. A variant of estrogen receptor-alpha, ER-alpha36 is expressed in human gastric cancer and is highly correlated with lymph node metastasis. Oncol. Rep. 24 (1): 171-176. 10.3892/or-00000842. 20514458.
28. Denger S. Reid G. Kos M. Flouriot G. Parsch D. Brand H. Korach K.S. Sonntag-Buck V. Gannon F. 2001. ER alpha gene expression in human primary osteoblasts: evidence for the expression of two receptor proteins. Mol. Endocrinol. 15 (12): 2064-2077. 10.1210/me.15.12.2064. 11731609. (Pubitemid 33141127)
29. Diamanti-Kandarakis E. Bourguignon J.P. Giudice L.C. Hauser R. Prins G.S. Soto A.M. Zoeller R.T. Gore A.C. 2009. Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement. Endocr. Rev. 30 (4): 293-342. 10.1210/Er.2009-0002. 19502515.
30. Dickerson S.M. Gore A.C. 2007. Estrogenic environmental endocrine-disrupting chemical effects on reproductive neuroendocrine function and dysfunction across the life cycle. Rev. Endocr. Metab. Disord. 8 (2): 143-159. 10.1007/s11154-007-9048-y. 17674209. (Pubitemid 47434648)
31. Diotel N. Do Rego J.L. Anglade I. Vaillant C. Pellegrini E. Vaudry H. Kah O. 2011. The Brain of Teleost Fish, a Source, and a Target of Sexual Steroids. Front. Neurosci. 5: 137. 10.3389/fnins.2011.00137. 22194715.
32. Dittmar K.D. Hutchison K.A. Owens-Grillo J.K. Pratt W.B. 1996. Reconstitution of the steroid receptor.hsp90 heterocomplex assembly system of rabbit reticulocyte lysate. J. Biol. Chem. 271 (22): 12833-9. 10.1074/jbc.271.22.12833. 8662785. (Pubitemid 26175857)
33. Divekar S.D. Storchan G.B. Sperle K. Veselik D.J. Johnson E. Dakshanamurthy S. Lajiminmuhip Y.N. Nakles R.E. Huang L. Martin M.B. 2011. The role of calcium in the activation of estrogen receptor-alpha. Cancer Res. 71 (5): 1658-1668. 10.1158/0008-5472.CAN-10-1899.3057389. 21212417.
34. Dong S. Terasaka S. Kiyama R. 2011. Bisphenol A induces a rapid activation of Erk1/2 through GPR30 in human breast cancer cells. Environ. Pollut. 159 (1): 212-218. 10.1016/j.envpol.2010.09.004. 20875696.
35. Donley, C., McClelland, K., McKeen, H.D., Nelson, L., Yakkundi, A., Jithesh, P.V., Burrows, J., et al. 2013 Identification of Rbck1 as a Novel Regulator of Fkbpl: Implications for Tumor Growth and Response to Tamoxifen. Oncogene, 10.1038/onc.2013.306
36. Dutertre M. Smith C.L. 2003. Ligand-independent interactions of p160/steroid receptor coactivators and CREB-binding protein (CBP) with estrogen receptor-alpha: Regulation by phosphorylation sites in the A/B region depends on other receptor domains. Mol. Endocrinol. 17 (7): 1296-1314. 10.1210/Me.2001-0316. 12714702. (Pubitemid 36819952)
37. Elbi C. Walker D.A. Romero G. Sullivan W.P. Toft D.O. Hager G.L. DeFranco D.B. 2004. Molecular chaperones function as steroid receptor nuclear mobility factors. Proc. Natl. Acad. Sci. U. S. A. 101 (9): 2876-2881. 10.1073/pnas.0400116101. 14978266. (Pubitemid 38327704)
38. Etique N. Flament S. Lecomte J. Grillier-Vuissoz I. 2007. Ethanol-induced ligand-independent activation of ERalpha mediated by cyclic AMP/PKA signaling pathway: an in vitro study on MCF-7 breast cancer cells. Int. J. Oncol. 31 (6): 1509-1518. 17982678.
39. Flint A.P. Sheldrick E.L. Fisher P.A. 2002. Ligand-independent activation of steroid receptors. Domest. Anim. Endocrinol. 23 (1-2): 13-24. 10.1016/S0739-7240(02)00141-8. 12142222.
40. Flouriot G. Brand H. Denger S. Metivier R. Kos M. Reid G. Sonntag-Buck V. Gannon F. 2000. Identification of a new isoform of the human estrogen receptor-alpha (hER-alpha) that is encoded by distinct transcripts and that is able to repress hER-alpha activation function 1. Embo J. 19 (17): 4688-4700. 10.1093/emboj/19.17.4688. 10970861.
41. Fogarty E.A. Matulis C.K. Kraus W.L. 2012. Activation of estrogen receptor alpha by raloxifene through an activating protein-1-dependent tethering mechanism in human cervical epithelial cancer cells: a role for c-Jun N-terminal kinase. Mol. Cell. Endocrinol. 348 (1): 331-338. 10.1016/j.mce.2011. 09.032. 21964465.
42. Gao F. Ma X. Ostmann A.B. Das S.K. 2011. GPR30 activation opposes estrogen-dependent uterine growth via inhibition of stromal ERK1/2 and estrogen receptor alpha (ERalpha) phosphorylation signals. Endocrinology, 152 (4): 1434-1447. 10.1210/en.2010-1368. 21303939.
43. Gao H. Katzenellenbogen J.A. Garg R. Hansch C. 1999. Comparative QSAR analysis of estrogen receptor ligands. Chem. Rev. 99 (3): 723-744. 10.1021/cr980018g. 11749430.
44. Garcia-Arencibia M. Davila N. Campion J. Carmen Carranza M. Calle C. 2005. Identification of two functional estrogen response elements complexed with AP-1-like sites in the human insulin receptor gene promoter. J. Steroid Biochem. Mol. Biol. 94 (1-3): 1-14. 10.1016/j.jsbmb.2004.12.020. 15862945. (Pubitemid 40614514)
45. Guo R.X. Wei L.H. Tu Z. Sun P.M. Wang J.L. Zhao D. Li X.P. Tang J.M. 2006. 17 beta-estradiol activates PI3K/Akt signaling pathway by estrogen receptor (ER)-dependent and ER-independent mechanisms in endometrial cancer cells. J. Steroid Biochem. Mol. Biol. 99 (1): 9-18. 10.1016/j.jsbmb.2005.11.013. 16567092. (Pubitemid 44382541)
46. Guo X.M. Razandi M. Pedram A. Kassab G. Levin E.R. 2005. Estrogen induces vascular wall dilation-Mediation through kinase signaling to nitric oxide and estrogen receptors alpha and beta. J. Biol. Chem. 280 (20): 19704-19710. 10.1074/jbc.M501244200. 15764600. (Pubitemid 41379495)
47. Gurevich I. Flores A.M. Aneskievich B.J. 2007. Corepressors of agonist-bound nuclear receptors. Toxicol. Appl. Pharm. 223 (3): 288-298. 10.1016/j.taap.2007.05.019. (Pubitemid 47362217)
48. Hall J.M. McDonnell D.P. Korach K.S. 2002. Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements. Mol. Endocrinol. 16 (3): 469-486. 10.1210/Me.16.3.469. 11875105. (Pubitemid 34214567)
49. Hayashi H. Nishimoto A. Oshima N. Iwamuro S. 2007. Expression of the estrogen receptor alpha gene in the anal fin of Japanese medaka, Oryzias latipes, by environmental concentrations of bisphenol A. J. Toxicol. Sci. 32 (1): 91-96. 10.2131/jts.32.91. 17327697. (Pubitemid 46334073)
50. Holmes K.A. Hurtado A. Brown G.D. Launchbury R. Ross-Innes C.S. Hadfield J. Odom D.T. Carroll J.S. 2012. Transducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cells. Proc. Natl. Acad. Sci. U. S. A. 109 (8): 2748-2753. 10.1073/pnas.1018863108. 21536917.
51. Huang B. Wang B. Ren D. Jin W. Liu J.L. Peng J.H. Pan X.J. 2013. Occurrence, removal and bioaccumulation of steroid estrogens in Dianchi Lake Catchment, China. Environ. Int. 59 (C): 262-273. 10.1016/j.envint.2013.06.018. 23850587.
52. Hurtado A. Holmes K.A. Ross-Innes C.S. Schmidt D. Carroll J.S. 2011. FOXA1 is a key determinant of estrogen receptor function and endocrine response. Nature Genet. 43 (1): U27-U42. 10.1038/Ng.730. 21151129.
53. Hutchinson T.H. Ankley G.T. Segner H. Tyler C.R. 2006. Screening and testing for endocrine disruption in fish-biomarkers as "signposts," not "traffic lights," in risk assessment. Environ. Health Perspect. 114 (Suppl 1): 106-114. 10.1289/ehp.8062.
54. Inoshita H. Masuyama H. Hiramatsu Y. 2003. The different effects of endocrine-disrupting chemicals on estrogen receptor-mediated transcription through interaction with coactivator TRAP220 in uterine tissue. J. Mol. Endocrinol. 31 (3): 551-561. 10.1677/jme.0.0310551. 14664715. (Pubitemid 38054525)
55. Jeng Y.J. Watson C.S. 2011. Combinations of physiologic estrogens with xenoestrogens alter ERK phosphorylation profiles in rat pituitary cells. Environ. Health Perspect. 119 (1): 104-112. 10.1289/ehp.1002512.3018487. 20870566.
56. Jiang H.P. Teng R.Y. Wang Q. Zhang X. Wang H.H. Wang Z.Y. Cao J. Teng L.S. 2008. Transcriptional analysis of estrogen receptor alpha variant mRNAs in colorectal cancers and their matched normal colorectal tissues. J. Steroid Biochem. Mol. Biol. 112 (1-3): 20-24. 10.1016/j.jsbmb.2008.07.004. 18703141.
57. Kang K. Lee S.B. Jung S.H. Cha K.H. Park W.D. Sohn Y.C. Nho C.W. 2009. Tectoridin, a poor ligand of estrogen receptor alpha, exerts its estrogenic effects via an ERK-dependent pathway. Mol. Cells 27 (3): 351-357. 10.1007/s10059-009-0045-8.
58. Kang L. Zhang X. Xie Y. Tu Y. Wang D. Liu Z. Wang Z.Y. 2010. Involvement of estrogen receptor variant ER-alpha36, not GPR30, in nongenomic estrogen signaling. Mol. Endocrinol. 24 (4): 709-721. 10.1210/me.2009-0317. 20197310.
59. Kekatpure V.D. Dannenberg A.J. Subbaramaiah K. 2009. HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling. J. Biol. Chem. 284 (12): 7436-45. 10.1074/jbc.M808999200. 19158084.
60. Kelly M.J. Levin E.R. 2001. Rapid actions of plasma membrane estrogen receptors. Trends Endocrinol. Metab. 12 (4): 152-156. 10.1016/S1043-2760(01) 00377-0. 11295570. (Pubitemid 33713555)
61. Kim J.Y. Oh K.N. Han E.H. Kim D.H. Jeong T.C. Lee E.S. Jeong H.G. 2005. Methoxychlor-induced inducible nitric oxide synthase and proinflammatory cytokines expression in macrophages via NF-kappaB, ERK, and p38 mitogen-activated protein kinases. Biochem. Biophys. Res. Commun. 333 (4): 1234-1240. 10.1016/j.bbrc.2005.06.038. 15979571.
62. Kim S.H. Kim S.H. Kim Y.B. Jeon Y.T. Lee S.C. Song Y.S. 2009. Genistein inhibits cell growth by modulating various mitogen-activated protein kinases and AKT in cervical cancer cells. Ann. N.Y. Acad. Sci. 1171: 495-500. 10.1111/j.1749-6632.2009.04899.x. 19723095.
63. Klotz D.M. Hewitt S.C. Ciana P. Raviscioni M. Lindzey J.K. Foley J. Maggi A. DiAugustine R.P. Korach K.S. 2002. Requirement of estrogen receptor-alpha in insulin-like growth factor-1 (IGF-1)-induced uterine responses and in vivo evidence for IGF-1/estrogen receptor cross-talk. J. Biol. Chem. 277 (10): 8531-8537. 10.1074/jbc.M109592200. 11751931. (Pubitemid 34968316)
64. Laganiere J. Deblois G. Lefebvre C. Bataille A.R. Robert F. Giguere V. 2005. Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response. Proc. Natl. Acad. Sci. U. S. A. 102 (33): 11651-11656. 10.1073/pnas.0505575102. 16087863. (Pubitemid 41170781)
65. Lannigan D.A. 2003. Estrogen receptor phosphorylation. Steroids, 68 (1): 1-9. 10.1016/S0039-128X(02)00110-1. 12475718. (Pubitemid 35418300)
66. Leclercq G. 2012. Calcium-induced activation of estrogen receptor alpha-New insight. Steroids, 77 (10): 924-927. 10.1016/j.steroids.2012.01.012. 22306577.
67. Lee Y.J. Lee H.G. Yang J.H. 2013. Perfluorooctane sulfonate-induced apoptosis of cerebellar granule cells is mediated by ERK 1/2 pathway. Chemosphere, 90 (5): 1597-1602. 10.1016/j.chemosphere.2012.08.033. 22990021.
68. Lee Y.M. Seo J.S. Kim I.C. Yoon Y.D. Lee J.S. 2006. Endocrine disrupting chemicals (bisphenol A, 4-nonylphenol, 4-tert-octylphenol) modulate expression of two distinct cytochrome P450 aromatase genes differently in gender types of the hermaphroditic fish Rivulus marmoratus. Biochem. Biophys. Res. Commun. 345 (2): 894-903. 10.1016/j.bbrc.2006.04.137. 16707107. (Pubitemid 43776978)
69. Levin E.R. 2008. Rapid signaling by steroid receptors. Am. J. Physiol.-Regul. Integr. Comp. Physiol. 295 (5): R1425-R1430. 10.1152/ajpregu.90605.2008. 18784332.
70. Levin E.R. 2009. Plasma membrane estrogen receptors. Trends Endocrinol. Metab. 20 (10): 477-482. 10.1016/j.tem.2009.06.009. 19783454.
71. Li L. Haynes M.P. Bender J.R. 2003. Plasma membrane localization and function of the estrogen receptor alpha variant (ER46) in human endothelial cells. Proc. Natl. Acad. Sci. U. S. A. 100 (8): 4807-4812. 10.1073/pnas. 0831079100. 12682286. (Pubitemid 36457810)
72. Li Y. Luh C.J. Burns K.A. Arao Y. Jiang Z. Teng C.T. Tice R.R. Korach K.S. 2013. Endocrine-disrupting chemicals (EDCs): in vitro mechanism of estrogenic activation and differential effects on ER target genes. Environ. Health Perspect. 121 (4): 459-466, 466e1-6.10.1289/ehp.1205951.3620735. 23384675.
73. Li Z.H. Liu X.Y. Wang N. Chen J.S. Chen Y.H. Huang J.T. Su C.H. Xie F. Yu B. Chen D.J. 2012. Effects of decabrominated diphenyl ether (PBDE-209) in regulation of growth and apoptosis of breast, ovarian, and cervical cancer cells. Environ. Health Perspect. 120 (4): 541-546. 10.1289/ehp.1104051. 22472210.
74. Lin C.Y. Vega V.B. Thomsen J.S. Zhang T. Kong S.L. Xie M. Chiu K.P. Lipovich L. Barnett D.H. Stossi F. Yeo A. George J. Kuznetsov V.A. Lee Y.K. Charn T.H. Palanisamy N. Miller L.D. Cheung E. Katzenellenbogen B.S. Ruan Y. Bourque G. Wei C.L. Liu E.T. 2007. Whole-genome cartography of estrogen receptor alpha binding sites. PLoS Genet. 3 (6): 867-885. 10.1371/journal.pgen.0030087. 1885282.
75. Lin S.L. Yan L.Y. Zhang X.T. Yuan J. Li M. Qiao J. Wang Z.Y. Sun Q.Y. 2010. ER-alpha36, a variant of ER-alpha, promotes tamoxifen agonist action in endometrial cancer cells via the MAPK/ERK and PI3K/Akt pathways. PloS one 5 (2): e9013. 10.1371/journal.pone.0009013.2814868.
76. Liu J.L. Wang R.M. Huang B. Lin C. Wang Y. Pan X.J. 2011. Distribution and bioaccumulation of steroidal and phenolic endocrine disrupting chemicals in wild fish species from Dianchi Lake, China. Environ. Pollut. 159 (10): 2815-2222. 10.1016/j.envpol.2011.05.013. 21645950.
77. Liu J.L. Wang R.M. Huang B. Lin C. Zhou J.L. Pan X.J. 2012. Biological effects and bioaccumulation of steroidal and phenolic endocrine disrupting chemicals in high-back crucian carp exposed to wastewater treatment plant effluents. Environ. Pollut. 162: 325-331. 10.1016/j.envpol.2011.11.036. 22243881.
78. Liu J.M. DeFranco D.B. 1999. Chromatin recycling of glucocorticoid receptors: Implications for multiple roles of heat shock protein 90. Mol. Endocrinol. 13 (3): 355-365. 10.1210/me.13.3.355. 10076993.
79. Liu Z.W. Yu X.Y. Shaikh Z.A. 2008. Rapid activation of ERK1/2 and AKT in human breast cancer cells by cadmium. Toxicol. Appl. Pharmacol. 228 (3): 286-294. 10.1016/j.taap.2007.12.017. 18275979.
80. Lupien M. Eeckhoute J. Meyer C.A. Wang Q.B. Zhang Y. Li W. Carroll J.S. Liu X.S. Brown M. 2008. FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Cell, 132 (6): 958-970. 10.1016/j.cell.2008.01.018. 18358809. (Pubitemid 351391952)
81. Maggiolini M. Picard D. 2010. The unfolding stories of GPR30, a new membrane-bound estrogen receptor. J. Endocrinol. 204 (2): 105-114. 10.1677/JOE-09-0242. 19767412.
82. Markey C.M. Rubin B.S. Soto A.M. Sonnenschein C. 2002. Endocrine disruptors: from Wingspread to environmental developmental biology. J. Steroid. Biochem. Mol. Biol. 83 (1-5): 235-244. 10.1016/S0960-0760(02)00272-8. 12650721. (Pubitemid 37045354)
83. Matthews J. Wihlen B. Tujague M. Wan J. Strom A. Gustafsson J.A. 2006. Estrogen receptor (ER) beta modulates ER alpha-mediated transcriptional activation by altering the recruitment of c-Fos and c-Jun to estrogen-responsive promoters. Mol. Endocrinol. 20 (3): 534-543. 10.1210/me.2005-0140. 16293641. (Pubitemid 43292585)
84. McKenna N.J. Lanz R.B. O'Malley B.W. 1999. Nuclear receptor coregulators: cellular and molecular biology. Endocr. Rev. 20 (3): 321-344. 10.1210/er.20.3.321. 10368774. (Pubitemid 30649811)
85. Meier S. Andersen T.E. Norberg B. Thorsen A. Taranger G.L. Kjesbu O.S. Dale R. Morton H.C. Klungsoyr J. Svardal A. 2007. Effects of alkylphenols on the reproductive system of Atlantic cod (Gadus morhua). Aquat. Toxicol. 81 (2): 207-218. 10.1016/j.aquatox.2006.12.002. 17207868. (Pubitemid 46223589)
86. Metivier R. Stark A. Flouriot G. Hubner M.R. Brand H. Penot G. Manu D. Denger S. Reid G. Kos M. Russell R.B. Kah O. Pakdel F. Gannon F. 2002. A dynamic structural model for estrogen receptor-alpha activation by ligands, emphasizing the role of interactions between distant A and E domains. Mol. Cell 10 (5): 1019-1032. 10.1016/S1097-2765(02)00746-3. (Pubitemid 35453823)
87. Nettles K.W. Bruning J.B. Gil G. Nowak J. Sharma S.K. Hahm J.B. Kulp K. Hochberg R.B. Zhou H. Katzenellenbogen J.A. Katzenellenbogen B.S. Kim Y. Joachmiak A. Greene G.L. 2008. NF kappa B selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses. Nat. Chem. Biol. 4 (4): 241-247. 10.1038/nchembio.76. 18344977. (Pubitemid 351414832)
88. Norman A.W. Mizwicki M.T. Norman D.P. 2004. Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model. Nat. Rev. Drug. Discov. 3 (1): 27-41. 10.1038/nrd1283. 14708019. (Pubitemid 38088696)
89. Okamoto T. Schlegel A. Scherer P.E. Lisanti M.P. 1998. Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane. J. Biol. Chem. 273 (10): 5419-5422. 10.1074/jbc.273.10.5419. 9488658. (Pubitemid 28123999)
90. Ortiz-Zarragoitia M. Cajaraville M.P. 2005. Effects of selected xenoestrogens on liver peroxisomes, vitellogenin levels and spermatogenic cell proliferation in male zebrafish. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 141 (2): 133-144. 10.1016/j.cca.2005.05.010. 16002344. (Pubitemid 41335482)
91. Papaconstantinou A.D. Fisher B.R. Umbreit T.H. Goering P.L. Lappas N.T. Brown K.M. 2001. Effects of beta-estradiol and bisphenol A on heat shock protein levels and localization in the mouse uterus are antagonized by the antiestrogen ICI 182,780. Toxicol. Sci. 63 (2): 173-180. 10.1093/toxsci/63.2.173. 11568360. (Pubitemid 32982790)
92. Papoutsi Z. Zhao C. Putnik M. Gustafsson J.A. Dahlman-Wright K. 2009. Binding of estrogen receptor α/β heterodimers to chromatin in MCF-7 cells. J. Mol. Endocrinol. 43 (2): 65-72. 10.1677/JME-08-0177. 19376833.
93. Pedram A. Razandi M. Levin E.R. 2006. Nature of functional estrogen receptors at the plasma membrane. Mol. Endocrinol. 20 (9): 1996-2009. 10.1210/me.2005-0525. 16645038. (Pubitemid 44286700)
94. Petrovic M. Eljarrat E. Lopez de Alda M.J. Barceló D. 2004. Endocrine disrupting compounds and other emerging contaminants in the environment: a survey on new monitoring strategies and occurrence data. Anal. Bioanal. Chem. 378 (3): 549-562. 10.1007/s00216-003-2184-7. 12955281. (Pubitemid 40877745)
95. Prossnitz E.R. Maggiolini M. 2009. Mechanisms of estrogen signaling and gene expression via GPR30. Mol. Cell. Endocrinol. 308 (1-2): 32-38. 10.1016/j.mce.2009.03.026. 19464786.
96. Qing L. Pallas D.C. Surks H.K. Baur W.E. Mendelsohn M.E. Karas R.H. 2004. Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha. Proc. Natl. Acad. Sci. U. S. A. 101 (49): 17126-17131. 10.1073/pnas.0407492101. 15569929. (Pubitemid 39627785)
97. Quesada I. Fuentes E. Viso-Leon M.C. Soria B. Ripoll C. Nadal A. 2002. Low doses of the endocrine disruptor bisphenol-A and the native hormone 17beta-estradiol rapidly activate transcription factor CREB. Faseb J. 16 (12): 1671-1673. 10.1096/fj.02-0313fje. 12207000.
98. Radice S. Chiesara E. Frigerio S. Fumagalli R. Parolaro D. Rubino T. Marabini L. 2006. Estrogenic effect of procymidone through activation of MAPK in MCF-7 breast carcinoma cell line. Life Sci. 78 (23): 2716-2723. 10.1016/j.lfs.2005.10.008. 16310225. (Pubitemid 44316668)
99. Ramachandran B. Makela S. Cravedi J.P. Berglund M. Hakansson H. Damdimopoulou P. Maggi A. 2011. Estrogen-like effects of diet-derived cadmium differ from those of orally administered CdCl(2) in the ERE-luc estrogen reporter mouse model. Toxicol. Lett. 202 (2): 75-84. 10.1016/j.toxlet.2010.12. 022. 21195146.
100. Razandi M. Pedram A. Greene G.L. Levin E.R. 1999. Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: Studies of ER alpha and ER beta expressed in Chinese hamster ovary cells. Mol. Endocrinol. 13 (2): 307-319. 10.1210/me.13.2.307. 9973260. (Pubitemid 29068005)
101. Razandi M. Pedram A. Levin E.R. 2010. Heat Shock Protein 27 Is Required for Sex Steroid Receptor Trafficking to and Functioning at the Plasma Membrane. Mol. Cell. Biol. 30 (13): 3249-3261. 10.1128/MCB.01354-09. 20439495.
102. Razandi M. Pedram A. Park S.T. Levin E.R. 2003. Proximal events in signaling by plasma membrane estrogen receptors. J. Biol. Chem. 278 (4): 2701-2712. 10.1074/jbc.M205692200. 12421825. (Pubitemid 36801351)
103. Salian S. Doshi T. Vanage G. 2009. Impairment in protein expression profile of testicular steroid receptor coregulators in male rat offspring perinatally exposed to Bisphenol A. Life Sci. 85 (1-2): 11-18. 10.1016/j.lfs.2009.04.005. 19379760.
104. Sanchez E.R. Toft D.O. Schlesinger M.J. Pratt W.B. 1985. Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein. J. Biol. Chem. 260 (23): 12398-12401. 3900074. (Pubitemid 16233437)
105. Sanderson J.T. 2006. The steroid hormone biosynthesis pathway as a target for endocrine-disrupting chemicals. Toxicol. Sci. 94 (1): 3-21. 10.1093/toxsci/kfl051. 16807284. (Pubitemid 44542325)
106. Schodin D.J. Zhuang Y. Shapiro D.J. Katzenellenbogen B.S. 1995. Analysis of mechanisms that determine dominant negative estrogen receptor effectiveness. J. Biol. Chem. 270 (52): 31163-31171. 10.1074/jbc.270.52.31163. 8537380. (Pubitemid 26012204)
107. Scroggins B.T. Robzyk K. Wang D. Marcu M.G. Tsutsumi S. Beebe K. Cotter R.J. Felts S. Toft D. Karnitz L. Rosen N. Neckers L. 2007. An acetylation site in the middle domain of Hsp90 regulates chaperone function. Mol. Cell 25 (1): 151-159. 10.1016/j.molcel.2006.12.008.1839984. (Pubitemid 46049066)
108. Seng D. Hoell A. Mussler B. Eisenbrand G. 2001. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor alpha and beta. Naunyn-Schmiedebergs Arch. Pharmacol. 363: R144.
109. Shanle E.K. Xu W. 2011. Endocrine disrupting chemicals targeting estrogen receptor signaling: identification and mechanisms of action. Chem. Res. Toxicol. 24 (1): 6-19. 10.1021/tx100231n. 21053929.
110. Shanthanagouda A.H. Patil J.G. Nugegoda D. 2013. Effects of Exposure to Oestrogenic Compounds on Aromatase Gene Expression Are Gender Dependent in the Rainbowfish, Melanotaenia Fluviatilis. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2 (157): 162-171. 10.1016/j.cbpc.2012.11.004.
111. Sheng Z.G. Huang W. Liu Y.X. Zhu B.Z. 2013. Bisphenol A at a low concentration boosts mouse spermatogonial cell proliferation by inducing the G protein-coupled receptor 30 expression. Toxicol. Appl. Pharmacol. 267 (1): 88-94. 10.1016/j.taap.2012.12.014. 23274518.
112. Shiau A.K. Barstad D. Loria P.M. Cheng L. Kushner P.J. Agard D.A. Greene G.L. 1998. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell, 95 (7): 927-937. 10.1016/S0092-8674(00)81717-1. 9875847. (Pubitemid 29019045)
113. Shiau A.K. Barstad D. Radek J.T. Meyers M.J. Nettles K.W. Katzenellenbogen B.S. Katzenellenbogen J.A. Agard D.A. Greene G.L. 2002. Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism. Nat. Struct. Biol. 9 (5): 359-364. 10.1038/nsb787. 11953755. (Pubitemid 34462554)
114. Shyu C. Cavileer T.D. Nagler J.J. Ytreberg F.M. 2011. Computational estimation of rainbow trout estrogen receptor binding affinities for environmental estrogens. Toxicol. Appl. Pharm. 250 (3): 322-326. 10.1016/j.taap.2010.11.005.
115. Simpson N.E. Gertz J. Imberg K. Myers R.M. Garabedian M.J. 2012. Research Resource: Enhanced Genome-Wide Occupancy of Estrogen Receptor Alpha by the Cochaperone P23 in Breast Cancer Cells. Mol. Endocrinol. 26 (1): 194-202. 10.1210/me.2011-1068. 22074947.
116. Smith D.F. Toft D.O. 2008. Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions. Mol. Endocrinol. 22 (10): 2229-2240. 10.1210/me.2008-0089. 18451092.
117. Song R.X. Barnes C.J. Zhang Z. Bao Y. Kumar R. Santen R.J. 2004. The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane. Proc. Natl. Acad. Sci. U.S.A. 101 (7): 2076-2081. 10.1073/pnas.0308334100. 14764897. (Pubitemid 38229017)
118. Song R.X. Santen R.J. 2006. Membrane initiated estrogen signaling in breast cancer. Biol. Reprod. 75 (1): 9-16. 10.1095/biolreprod.105.050070. 16571873. (Pubitemid 43946335)
119. Stender J.D. Kim K. Charn T.H. Komm B. Chang K.C.N. Kraus W.L. Benner C. Glass C.K. Katzenellenbogen B.S. 2010. Genome-Wide Analysis of Estrogen Receptor alpha DNA Binding and Tethering Mechanisms Identifies Runx1 as a Novel Tethering Factor in Receptor-Mediated Transcriptional Activation. Mol. Cell. Biol. 30 (16): 3943-3955. 10.1128/MCB.00118-10. 20547749.
120. Takayanagi S. Tokunaga T. Liu X.H. Okada H. Matsushima A. Shimohigashi Y. 2006. Endocrine disruptor bisphenol A strongly binds to human estrogen-related receptor gamma (ERR gamma) with high constitutive activity. Toxicol. Lett. 167 (2): 95-105. 10.1016/j.toxlet.2006.08.012. 17049190. (Pubitemid 44751375)
121. Tellez-Banuelos M.C. Ortiz-Lazareno P.C. Santerre A. Casas-Solis J. Bravo-Cuellar A. Zaitseva G. 2011. Effects of low concentration of endosulfan on proliferation, ERK1/2 pathway, apoptosis and senescence in Nile tilapia (Oreochromis niloticus) splenocytes. Fish. Shellfish. Immunol. 31 (6): 1291-1296. 10.1016/j.fsi.2011.10.003. 22008288.
122. Tetel M.J. 2009. Nuclear Receptor Coactivators: Essential Players for Steroid Hormone Action in the Brain and in Behaviour. J. Neuroendocrinol. 21 (4): 229-237. 10.1111/j.1365-2826.2009.01827.x. 19207820.
123. Thomas R.S. Sarwar N. Phoenix F. Coombes R.C. Ali S. 2008. Phosphorylation at serines 104 and 106 by Erk1/2 MAPK is important for estrogen receptor-alpha activity. J. Mol. Endocrinol. 40 (4): 173-184. 10.1677/JME-07-0165. 18372406. (Pubitemid 351586826)
124. Thrane S. Lykkesfeldt A.E. Larsen M.S. Sorensen B.S. Yde C.W. 2013. Estrogen receptor alpha is the major driving factor for growth in tamoxifen-resistant breast cancer and supported by HER/ERK signaling. Breast Cancer Res. Treat. 139 (1): 71-80. 10.1007/s10549-013-2485-2. 23609470.
125. Tong J.S. Zhang Q.H. Wang Z.B. Li S. Yang C.R. Fu X.Q. Hou Y. Wang Z.Y. Sheng J. Sun Q.Y. 2010. ER-alpha36, a novel variant of ER-alpha, mediates estrogen-stimulated proliferation of endometrial carcinoma cells via the PKCdelta/ERK pathway. PloS one 5 (11): e15408. 10.1371/journal.pone.0015408. 2973969.
126. Tong S.K. Chung B.C. 2003. Analysis of zebrafish cyp19 promoters. J. Steroid Biochem. Mol. Biol. 86 (3-5): 381-386. 10.1016/S0960-0760(03)00347-9. 14623534.
127. Wang J.J. Liu X.L. Wang H.P. Wu T.T. Hu X.Q. Qin F. Wang Z.Z. 2010. Expression of two cytochrome P450 aromatase genes is regulated by endocrine disrupting chemicals in rare minnow Gobiocypris rarus juveniles. Comp. Biochem. Physiol. C-Toxicol. Pharmacol. 152 (3): 313-320. 10.1016/j.cbpc.2010.05.007. 20594974.
128. Wang Z.Y. Zhang X.T. Shen P. Loggie B.W. Chang Y. Deuel T.F. 2006. A variant of estrogen receptor-alpha, hER-alpha 36: Transduction of estrogen-and antiestrogen-dependent membrane-initiated mitogenic signaling. Proc. Natl. Acad. Sci. U.S.A. 103 (24): 9063-9068. 10.1073/pnas.0603339103. 16754886. (Pubitemid 43902533)
129. Watson C.S. Bulayeva N.N. Wozniak A.L. Finnerty C.C. 2005. Signaling from the membrane via membrane estrogen receptor-alpha: estrogens, xenoestrogens, and phytoestrogens. Steroids, 70 (5-7): 364-371. 10.1016/j.steroids.2005.03.002. 15862819. (Pubitemid 40616034)
130. Watson C.S. Jeng Y.J. Kochukov M.Y. 2010. Nongenomic Signaling Pathways of Estrogen Toxicity. Toxicol. Sci. 115 (1): 1-11. 10.1093/toxsci/kfp288. 19955490.
131. Weatherman R.V. Clegg N.J. Scanlan T.S. 2001. Differential Serm Activation of the Estrogen Receptors (Eralpha and Erbeta) at Ap-1 Sites. Chem. Biol. 8 (5): 427-436. 10.1016/S1074-5521(01)00025-4. 11358690. (Pubitemid 32455897)
132. Wong T.T. Ijiri S. Zohar Y. 2006. Molecular biology of ovarian aromatase in sex reversal: complementary DNA and 5′-flanking region isolation and differential expression of ovarian aromatase in the gilthead seabream (Sparus aurata). Biol. Reprod. 74 (5): 857-864. 10.1095/biolreprod.105.045351. 16421234.
133. Wood J.R. Likhite V.S. Loven M.A. Nardulli A.M. 2001. Allosteric modulation of estrogen receptor conformation by different estrogen response elements. Mol. Endocrinol. 15 (7): 1114-1126. 10.1210/me.15.7.1114. 11435612. (Pubitemid 32614066)
134. Wormke M. Stoner M. Saville B. Walker K. Abdelrahim M. Burghardt R. Safe S. 2003. The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes. Mol. Cell. Biol. 23 (6): 1843-1855. 10.1128/MCB.23.6.1843-1855.2003. 12612060. (Pubitemid 36278799)
135. Xie H. Sun M. Liao X.B. Yuan L.Q. Sheng Z.F. Meng J.C. Wang D. Yu Z.Y. Zhang L.Y. Zhou H.D. Luo X.H. Li H. Wu X.P. Wei Q.Y. Tang S.Y. Wang Z.Y. Liao E.Y. 2011. Estrogen receptor alpha36 mediates a bone-sparing effect of 17beta-estrodiol in postmenopausal women. J. Bone. Miner. Res. 26 (1): 156-168. 10.1002/jbmr.169. 20578216.
136. Xu L. Glass C.K. Rosenfeld M.G. 1999. Coactivator and corepressor complexes in nuclear receptor function. Curr. Opin. Genet. Dev. 9 (2): 140-147. 10.1016/S0959-437X(99)80021-5. 10322133. (Pubitemid 29158546)
137. Xu X. Liu Y. Sadamatsu M. Tsutsumi S. Akaike M. Ushijima H. Kato N. 2007. Perinatal bisphenol A affects the behavior and SRC-1 expression of male pups but does not influence on the thyroid hormone receptors and its responsive gene. Neurosci. Res. 58 (2): 149-155. 10.1016/j.neures.2007.02.011. 17412439. (Pubitemid 46843325)
138. Zhang D.P. Trudeau V.L. 2006. Integration of membrane and nuclear estrogen receptor signaling. Comp. Biochem. Physiol. A-Mol. Integr. Physiol. 144 (3): 306-315. 10.1016/j.cbpa.2006.01.025. 16516516. (Pubitemid 43956565)
139. Zhang X.T. Kang L.G. Ding L. Vranic S. Gatalica Z. Wang Z.Y. 2011. A positive feedback loop of ER-alpha36/EGFR promotes malignant growth of ER-negative breast cancer cells. Oncogene, 30 (7): 770-780. 10.1038/onc.2010. 458. 20935677.
140. Zhang Z.P. Teng C.T. 2007. Interplay between estrogen-related receptor alpha (ERR alpha) and gamma (ERR gamma) on the regulation of ERR alpha gene expression. Mol. Cell. Endocrinol. 264 (1-2): 128-141. 10.1016/j.mce.2006.11. 002. 17157980. (Pubitemid 46110941)
141. Zou Y. Ding L. Coleman M. Wang Z.Y. 2009. Estrogen receptor-alpha (ER-alpha) suppresses expression of its variant ER-alpha 36. FEBS Lett. 583 (8): 1368-1374. 10.1016/j.febslet.2009.03.047. 19328202.