Effects of decabrominated diphenyl ether (PBDE-209) in regulation of growth and apoptosis of breast, ovarian, and cervical cancer cells

Environmental Health Perspectives

Volumn 120, Issue 4, 2012, Pages 541-546

  Li, Zhi Hua ^a   Liu, Xiao Yan ^a,d   Wang, Na ^b   Chen, Jing Si ^a   Chen, Yan Hong ^a   Huang, Jin Tao ^c   Su, Chun Hong ^a   Xie, Fukang ^c   Yu, Bin ^a   Chen, Dun Jin ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c SUN YAT SEN UNIVERSITY   (China)

^d Huizhou People's Hospital   (China)

Author keywords

Cell proliferation; Erk1 2; Female reproductive cancer; Pbde 209; Pkc

Indexed keywords

12 (2 CYANOETHYL) 6, 7, 12, 13 TETRAHYDRO 13 METHYL 5 OXOINDOLO [2, 3 A] PYRROLO [3, 4 C] CARBAZOLE; 2 (2 AMINO 3 METHOXYPHENYL) CHROMONE; DECABROMINATED DIPHENYL ETHER; POLYBROMINATED DIPHENYL ETHER; TAMOXIFEN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER GROWTH; CELL CYCLE REGULATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UTERINE CERVIX CANCER; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CHO CELLS; CRICETINAE; CRICETULUS; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HALOGENATED DIPHENYL ETHERS; HELA CELLS; HUMANS; OVARIAN NEOPLASMS; TAMOXIFEN; UTERINE CERVICAL NEOPLASMS;

CRICETULUS GRISEUS;

EID: 84859309758     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1104051     Document Type: Article

References (45)

1. Barber JL, Walsh MJ, Hewitt R, Jones KC, Martin FL. 2006. Low-dose treatment with polybrominated diphenyl ethers (PBDEs) induce altered characteristics in MCF-7 cells. Mutagenesis 21:351-360.
2. Bi X, Qu W, Sheng G, Zhang W, Mai B, Chen D, et al. 2006. Polybrominated diphenyl ethers in South China maternal and fetal blood and breast milk. Environ Pollut 144(3):1024-1030.
3. Birnbaum LS, Staskal DF. 2004. Brominated flame retardants: cause for concern? Environ Health Perspect 112:9-17.
4. Brown DJ, Van Overmeire I, Goeyens L, Denison MS, De Vito MJ, Clark GC. 2004. Analysis of Ah receptor pathway activation by brominated flame retardants. Chemosphere 55:1509-1518.
5. Ceccatelli R, Faass O, Schlumpf M, Lichtensteiger W. 2006. Gene expression and estrogen sensitivity in rat uterus after developmental exposure to polybrominated diphenyl ether PBDE 99 and PCB. Toxicology 220:104-116.
6. Clemens, MJ, Trayner I, Menaya J. 1992. The role of protein kinase C isoenzymes in the regulation of cell proliferation and differentiation. J Cell Sci 103:881-887.
7. Darnerud PO, Eriksen GS, Jóhannesson T, Larsen PB, Viluksela M. 2001. Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology. Environ Health Perspect 109(suppl 1):49-68.
8. Darnerud PO, Risberg S. 2006. Tissue localisation of tetra-and pentabromodiphenyl ether congeners (PBDE-47, -85 and -99) in perinatal and adult C57BL mice. Chemosphere 62:485-493.
9. Fujii T, Nakamura AM, Yokoyama G, Yamaguchi M, Tayama K, Miwa K, et al. 2005. Antineoplaston induces G1 arrest by PKCα and MAPK pathway in SKBR-3 breast cancer cells. Oncol Rep 14:489-494.
10. Guan YF, Sojinu OS, Li SM, Zeng EY. 2009. Fate of polybrominated diphenyl ethers in the environment of the Pearl River Estuary, South China. Environ Pollut 157(7):2166-2172.
11. Hamers T, Kamstra JH, Sonneveld E, Murk AJ, Kester MH, Andersson PL, et al. 2006. In vitro profiling of the endocrine-disrupting potency of brominated flame retardants. Toxicol Sci 92(1):157-173.
12. Hamers T, Kamstra JH, Sonneveld E, Murk AJ, Visser TJ, Van Velzen MJ, et al. 2008. Biotransformation of brominated flame retardants into potentially endocrine-disrupting metabolites, with special attention to 2,2',4,4'-tetrabromodiphenyl ether (BDE-47). Mol Nutr Food Res 52(2):284-298.
13. Helleday T, Tuominen KL, Bergman A, Jenssen D. 1999. Brominated flame retardants induce intragenic recombination in mammalian cells. Mutat Res 439:137-147.
14. Hu XZ, Xu Y, Hu DC, Hui Y, Yang FX. 2007. Apoptosis induction on human hepatoma cells Hep G2 of decabrominated diphenyl ether (PBDE-209). Toxicol Lett 171:19-28.
15. Hug H, Sarre TF. 1993. Protein kinase C isoenzymes: divergence in signal transduction? Biochem J 291:29-43.
16. International Agency for Research on Cancer. 1978. Polychlorinated biphenyls. IARC Monogr Eval Carcinog Risk Chem Hum 18:43-103.
17. International Agency for Research on Cancer. 1991. DDT and associated compounds. IARC Monogr Eval Carcinog Risk Chem Hum 53:179-249.
18. Kalantzi OI, Hewitt R, Ford KJ, Alcock, RE, Thomas GO, Morris JA, et al. 2004. Inter-individual differences in the ability of human milk-fat extracts to enhance the genotoxic potential of the procarcinogen benzo[a]pyrene in MCF-7 breast cells. Environ Sci Technol 38:3614-3622.
19. Khan QA, Dipple A. 2000. Diverse chemical carcinogens fail to induce G1 arrest in MCF-7 cells. Carcinogenesis 21(8):1611-1618.
20. Kuriyama SN, Talsness CE, Grote K, Chahoud I. 2005. Developmental exposure to low dose PBDE 99: effects on male fertility and neurobehavior in rat offspring. Environ Health Perspect 113:149-154.
21. La Guardia MJ, Hale RC, Harvey E. 2006. Detailed polybrominated diphenyl ether (PBDE) congener composition of the widely used penta-, octa-, and deca-PBDE technical fame-retardant mixtures. Environ Sci Technol 40:6247-6254.
22. Li C, Hu Y, Mayr M, Xu Q. 1999. Cyclic strain stress-induced mitogen-activated protein kinase (MAPK) phosphatase 1 expression in vascular smooth muscle cells is regulated by Ras/Rac-MAPK pathways. J Biol Chem 274:25273-25280.
23. Lilienthal H, Hack A, Roth-Harer A, Grande SW, Talsness CE. 2006. Effects of developmental exposure to 2,2 ́,4,4,5 ́-pentabromodiphenyl ether (PBDE-99) on sex steroids, sexual development, and sexually dimorphic behavior in rats. Environ Health Perspect 114:194-201.
24. Llabjani V, Trevisan J, Jones KC, Shore RF, Martin FL. 2010. Binary mixture effects by PBDE congeners (47, 153, 183, or 209) and PCB congeners (126 or 153) in MCF-7 cells: biochemical alterations assessed by IR spectroscopy and multivariate analysis. Environ Sci Technol 44(10):3992-3998.
25. Llabjani V, Trevisan J, Jones KC, Shore RF, Martin FL. 2011. Derivation by infrared spectroscopy with multivariate analysis of bimodal contaminant-induced dose-response effects in MCF-7 cells. Environ Sci Technol 45(14):6129-6135.
26. Mandil R, Ashkenazi E, Blass M, Kronfeld I, Kazimirsky G, Rosenthal G, et al. 2001. Protein kinase C α and protein kinase Cδ play opposite roles in the proliferation and apoptosis of glioma cells. Cancer Res 61:4612-4619.
27. McDonald TA. 2002. A perspective on the potential health risks of PBDEs. Chemosphere 46:745-755.
28. Meerts IA, van Zanden JJ, Luijks EA, van Leeuwen-Bol I, Marsh G, Jakobsson E, et al. 2000. Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro. Toxicol Sci 56:95-104.
29. Mercado-Feliciano M, Bigsby RM. 2008. The polybrominated diphenyl ether mixture DE-71 is mildly estrogenic. Environ Health Perspect 116:605-611.
30. Migliaccio A, Pagano M, Auricchio F. 1993. Immediate and transient stimulation of protein tyrosine phosphorylation by estradiol in MCF-7 cells. Oncogene 8:2183-2191.
31. Monje P, Boland R. 2002. Expression and cellular localization of naturally occurring beta estrogen receptors in uterine and mammary cell lines. J Cell Biochem 86(1):136-144.
32. Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63.
33. Richardson VM, Staskal DF, Ross DG, Diliberto JJ, DeVito MJ, Birnbaum LS. 2008. Possible mechanisms of thyroid hormone disruption in mice by BDE 47, a major polybrominated diphenyl ether congener. Toxicol Appl Pharmacol 226(3):244-250.
34. Shen HM, Ong CN, Shi CY. 1995. Involvement of reactive oxygen species in aflatoxin B1-induced cell injury in cultured rat hepatocytes. Toxicology 99:115-123.
35. Stoker TE, Laws SC, Crofton KM, Hedge JM, Ferrell JM, Cooper RL. 2004. Assessment of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture, in the EDSP male and female pubertal protocols. Toxicol Sci 78:144-155.
36. Talsness CE, Kuriyama SN, Sterner-Kock A, Schnitker P, Grande SW, Shakibaei M, et al. 2008. In utero and lactational exposures to low doses of polybrominated diphenyl ether-47 alter the reproductive system and thyroid gland of female rat offspring. Environ Health Perspect 116:308-314.
37. Talsness CE, Shakibaei M, Kuriyama SN, Wichert Grande S, Sterner-Kock A, Schnitker P, et al. 2005. Ultrastructural changes observed in rat ovaries following in utero and lactational exposure to low doses of a polybrominated flame retardant. Toxicol Lett 157:189-202.
38. Tan J, Cheng SM, Loganath A, Chong YS, Obbard JP. 2007. Polybrominated diphenyl ethers in house dust in Singapore. Chemosphere 66:985-992.
39. Tanaka Y, Gavrielides MV, Mitsuuchi Y, Fujii T, Kazanietz MG. 2003. Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway. J Biol Chem 278:33753-33762.
40. Thomsen C, Stigum H, Frøshaug M, Broadwell SL, Becher G, Eggesbø M. 2010. Determinants of brominated flame retardants in breast milk from a large scale Norwegian study. Environ Int 36(1):68-74.
41. Tian F, Wu H, Li Z, Wang N, Huang J, Li C, et al. 2009. Activated PKCα/ERK1/2 signaling inhibits tamoxifen-induced apoptosis in C6 cells. Cancer Invest 27:802-808.
42. Tseng LH, Lee CW, Pan MH, Tsai SS, Li MH, Chen JR, et al. 2006. Postnatal exposure of the male mouse to 2,2 ́,3,3 ́,4,4 ́,6,6 ́-decabrominated diphenyl ether: decreased epididymal sperm functions without alterations in DNA content and histology in testis. Toxicology 224:33-43.
43. Ukpebor J, Llabjani V, Martin FL, Halsall CJ. 2011. Sublethal genotoxicity and cell alterations by organophosphorus pesticides in MCF-7 cells: implications for environmentally relevant concentrations. Environ Toxicol Chem 30(3):632-639.
44. Zarubin T, Han J. 2005. Activation and signaling of the p38MAP kinase pathway. Cell Res 15:11-18.
45. Zhao GF, Wang ZJ, Zhou HD, Zhao Q. 2009. Burdens of PBBs, PBDEs, and PCBs in tissues of the cancer patients in the e-waste disassembly sites in Zhejiang, China. Sci Total Environ 407(17):4831-4837.