Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 37, 2012, Pages 14930-14935

  Delfosse, Vanessa ^a   Grimaldi, Marina ^b   Pons, Jean Luc ^a   Boulahtouf, Abdelhay ^b   Le Maire, Albane ^a   Cavailles, Vincent ^b   Labesse, Gilles ^a   Bourguet, William ^a   Balaguer, Patrick ^b  

^a UNIV MONTPELLIER   (France)

^b INSERM   (France)

Author keywords

Crystal structure; Endocrine disruptor; Nuclear receptor; Virtual screening

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ANDROGEN RECEPTOR; BISPHENOL AF; BISPHENOL C; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; PHENOL DERIVATIVE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DOSE RESPONSE; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; PRIORITY JOURNAL; RECEPTOR BINDING; RISK ASSESSMENT; TRANSCRIPTION INITIATION;

ANIMALS; CELL LINE; CHROMATOGRAPHY, GEL; CRYSTALLOGRAPHY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCRINE DISRUPTORS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FLUORESCENCE POLARIZATION; HUMANS; LUCIFERASES; MODELS, MOLECULAR; ONCORHYNCHUS MYKISS; PHENOLS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84866274611     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1203574109     Document Type: Article

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