Transcriptional analysis of estrogen receptor alpha variant mRNAs in colorectal cancers and their matched normal colorectal tissues

Journal of Steroid Biochemistry and Molecular Biology

Volumn 112, Issue 1-3, 2008, Pages 20-24

  Jiang, Haiping ^a,b   Teng, Rongyue ^a   Wang, Qi ^b   Zhang, Xing ^b   Wang, Haohao ^a   Wang, Zhaoyi ^c   Cao, Jiang ^b   Teng, Lisong ^a  

^a First Affiliated Hospital   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Colorectal cancer; Estrogen receptor alpha variant; Quantitative real time PCR

Indexed keywords

ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR ALPHA 36; ESTROGEN RECEPTOR ALPHA 46; ESTROGEN RECEPTOR ALPHA 66; MESSENGER RNA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CANCER GROWTH; CANCER STAGING; CANCER TISSUE; COLORECTAL CANCER; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MALE; RECEPTOR GENE; WILD TYPE;

ADULT; ALTERNATIVE SPLICING; COLON; COLORECTAL NEOPLASMS; ESTROGEN RECEPTOR ALPHA; FEMALE; HUMANS; LYMPH NODES; MALE; MIDDLE AGED; RECTUM; RNA, MESSENGER; RNA, NEOPLASM;

EID: 55349139288     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2008.07.004     Document Type: Article

References (33)

1. Martha C.T., Jeanette L., and Bhavna B. Expression of estrogen receptor (ER) subtypes and ERβ isoforms in colon cancer. Cancer Res. 61 (2001) 632-640
2. Greenlee R.T., Murra T., Bolden S., and Wingo P.A. Cancer statistics, 2000. CA Cancer J. Clin. 50 (2000) 3-7
3. Ries L.A., Wingo P.A., Miller D.S., Howe H.L., Weir H.K., Rosenberg H.M., Vernon S.W., Cronin K., and Edwards B.K. The annual report to the nation on the status of cancer, 1973-1997. Cancer (Phila) 88 (2000) 2398-2424
4. DeCosse J.J., Ngoi S.S., Jacobson J.S., and Cennerazzo W.J. Gender and colorectal cancer. Eur. J. Cancer Prev. 2 (1993) 105-111
5. Levi F., La Vecchia C., Randimbison L., Te V.C., and Franceschi S. Patterns of large bowel cancer by subsite, age, sex, and marital status. Tumori 77 (1991) 225-246
6. Paganini-Hill A. Estrogen replacement therapy and colorectal cancer risk in elderly women. Dis. Colon Rectum 42 (1999) 1300-1305
7. Nanda K., Bastian L.A., Hasselblad V., and Simel D.L. Hormone replacement therapy and the risk of colorectal cancer: a meta-analysis. Obstet. Gynecol. 93 (1999) 880-888
8. Grodstein F., Newcomb P.A., and Stampfer M.J. Postmenopausal hormone therapy and the risk of colorectal cancer: a review and meta-analysis. Am. J. Med. 106 (1999) 574-582
9. Hebert-Croteau N. A meta-analysis of hormone replacement therapy and colon cancer in women. Cancer Epidemiol. Biomarkers Prev. 7 (1998) 653-659
10. Franceschi S., and La Vecchia C. Colorectal cancer and hormone replacement therapy: an unexpected finding. Eur. J. Cancer Prev. 7 (1998) 427-438
11. Flouriot G., Brand H., Denger S., Metivier R., Kos M., Reid G., Sonntag-Buck V., and Gannon F. Identification of a new isoform of the human estrogen receptor-alpha (hER-α) that is encoded by distinct transcripts and that is able to repress hER-α activation function 1. EMBO J. 19 (2000) 4688-4700
12. Dotzlaw H., Leygue E., Watson P., and Murphy L. Expression of estrogen receptor beta in human breast tumors. J. Clin. Endocrinol. Metab. 82 (1997) 2371-2374
13. McGuire W.L., Chamness G.C., and Fuqua S.A.W. Estrogen receptor variants in clinical breast cancer. Mol. Endocrinol. 5 (1991) 1571-1577
14. Fuqua S.A.W., Fitzgerald S.D., Chammness G.C., Tandon A.K., McDonnell D.P., Nawaz Z., O'Malley B.W., and McGuire W.L. Variant human breast tumor estrogen receptor with constitutive activity. Cancer Res. 51 (1991) 105-109
15. Castles C.G., Fuqua S.A.W., Klot D., and Hill S.M. Expression of a constitutionally active estrogen receptor variant in the estrogen receptor negative BT-20 human breast cancer cell line. Cancer Res. 53 (1993) 593-599
16. Leygue E., Huang A., Murphy L.C., and Watson P.H. Prevalence of estrogen receptor variant messenger RNAs in human breast cancer. Cancer Res. 56 (1996) 4324-4327
17. Poola I., Koduri S., Chatra S., and Clarke R. Identification of twenty alternatively spliced estrogen receptor alpha mRNAs in breast cancer cell lines and tumors using spliced targeted primer approach. J. Steroid Biochem. Mol. Biol. 72 (2000) 249-258
18. Pfeffer U., Fecarotta E., and Vidali G. Coexpression of multiple estrogen receptor variant messenger RNAs in normal and neoplastic breast tissues and MCF-7 cells. Cancer Res. 55 (1995) 2158-2165
19. Gotteland M., Desuty G., Delarue J.C., Liu L., and May E. Human estrogen receptor mRNA variants in both normal and tumor tissues. Mol. Cell. Endocrinol. 112 (1995) 1-13
20. Issa J.P., Ottaviano Y.L., Celano P., Hamilton S.R., Davidson N.E., and Baylin S.B. Methylation of the oestrogen receptor CpG island links aging and neoplasia inhuman colon. Nat. Genet. 7 (1994) 536-540
21. Nita A., Qing L., Avinash L., and Mohan S.B. Aging and DNA methylation in colorectal mucosa and cancer. Cancer Res. 58 (1998) 5489-5494
22. Nancy L.C., Sara H.J., Adelaide M.C., Mark R., and Monica M.B. Estrogen receptors A and B are inhibitory modifiers of Apc-dependent tumorigenesis in the proximal colon of Min/+ mice. Cancer Res. 67 (2007) 2366-2372
23. Denger S., Reid G., Kos M., Flouriot G., Parsch D., Brand H., Korach K.S., Sonntag-Buck V., and Gannon F. ERα gene expression in human primary osteoblasts: evidence for the expression of two receptor proteins. Mol. Endocrinol. 15 (2000) 2064-2077
24. Li L., Haynes M.P., and Bender J.R. Plasma membrane localization and function of the estrogen receptor α variant (ER46) in human endothelial cells. Proc. Natl. Acad. Sci. 100 (2003) 4807-4812
25. Wang Z.Y., Zhang X.T., Shen P., Loggie B.W., Chang Y.C., and Deuel T.F. A variant of estrogen receptor-α, hER-α36: transduction of estrogen- and antiestrogen-dependent membrane-initiated mitogenic signaling. Proc. Natl. Acad. Sci. 103 (2006) 9063-9068
26. Poola I., Clarke R., DeWitty R., and Laffell L.D. Functionally active estrogen receptor isoform profiles in the breast tumors of African American women are distinct from profiles in breast tumors of Caucasian women. Cancer 94 (2002) 615-623
27. -ΔΔCT method. Methods 25 (2001) 402-408
28. Singh S., Sheppard M.C., and Langmanm M.J.S. Sex differences in the incidence of colorectal cancer: an exploration of oestrogen and progesterone receptors. Gut 34 (1993) 611-615
29. Oshima C.T., Wonraht D.R., Catarino R.M., Maltos D., and Forones N.M. Estrogen and progesterone receptors in gastric and colorectal cancer. Hepato-Gastroenterol. 46 (1999) 3155-3158
30. Slattery M.L., Samowitz W.S., and Holden J.A. Estrogen and progesterone receptors in colon tumors. Am. J. Clin. Pathol. 113 (2000) 364-368
31. Poola I., and Yue Q.Q. Estrogen receptor alpha (ERα) mRNA copy numbers in immunohistochemically ERα-positive-, and negative breast cancer tissues. BMC Cancer 7 (2007) 56-66
32. Di Leo A., Messa C., Cavallini A., and Linsalata M. Estrogen and colorectal cancer. Curr. Drug Targets Immune Endocr. Metabol. Disord. 1 (2001) 1-12
33. Cavallini A., Messa C., Pricci M., Caruso M.L., Barone M., and Dileo A. Distribution of estrogen receptor subtypes, expression of their variant forms, and clinicopathological characteristics of human colorectal cancer. Dig. Dis. Sci. 47 (2002) 2720-2728