Transducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 8, 2012, Pages 2748-2753

  Holmes, Kelly A ^a   Hurtado, Antoni ^a   Brown, Gordon D ^a   Launchbury, Rosalind ^a   Ross Innes, Caryn S ^a   Hadfield, James ^b   Odom, Duncan T ^a,c   Carroll, Jason S ^a,c  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b Genomics Core   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; ESTROGEN RECEPTOR; PHOSPHOPROTEIN; RNA POLYMERASE II; TRANSDUCIN LIKE ENHANCER PROTEIN 1; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; BREAST CANCER; CANCER CELL; CELL DIVISION; CELL STRAIN MCF 7; CHROMATIN; CONTROLLED STUDY; GENE EXPRESSION; GENE SILENCING; GENOME; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; RECEPTOR BINDING; TRANSCRIPTION REGULATION;

BINDING SITES; BREAST NEOPLASMS; CELL LINE, TUMOR; CHROMATIN; ESTROGEN RECEPTOR ALPHA; ESTROGENS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATOCYTE NUCLEAR FACTOR 3-ALPHA; HUMANS; PROTEIN BINDING; REPRESSOR PROTEINS; TRANSCRIPTION, GENETIC;

EID: 84863393402     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1018863108     Document Type: Article

References (27)

1. Sorlie T, et al. (2001) Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 98:10869-10874. (Pubitemid 32878711)
2. Ali S, Coombes RC (2002) Endocrine-responsive breast cancer and strategies for combating resistance. Nat Rev Cancer 2:101-112. (Pubitemid 37328797)
3. Cirillo LA, et al. (1998) Binding of the winged-helix transcription factor HNF3 to a linker histone site on the nucleosome. EMBO J 17:244-254. (Pubitemid 28041065)
4. Cirillo LA, et al. (2002) Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4. Mol Cell 9:279-289. (Pubitemid 34195554)
5. Carroll JS, et al. (2005) Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell 122:33-43. (Pubitemid 40977938)
6. Laganiere J, et al. (2005) Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response. Proc Natl Acad Sci USA 102:11651-11656. (Pubitemid 41170781)
7. Lupien M, et al. (2008) FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Cell 132:958-970. (Pubitemid 351391952)
8. Hurtado A, Holmes KA, Ross-Innes CS, Schmidt D, Carroll JS (2011) FOXA1 is a key determinant of estrogen receptor function and endocrine response. Nat Genet 43:27-33.
9. Palaparti A, Baratz A, Stifani S (1997) The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3. J Biol Chem 272:26604-26610. (Pubitemid 27458883)
10. Sekiya T, Zaret KS (2007) Repression by Groucho/TLE/Grg proteins: genomic site recruitment generates compacted chromatin in vitro and impairs activator binding in vivo. Mol Cell 28:291-303. (Pubitemid 47600002)
11. Cinnamon E, Paroush Z (2008) Context-dependent regulation of Groucho/TLE-mediated repression. Curr Opin Genet Dev 18:435-440. (Pubitemid 50262327)
12. Cai Y, Brophy PD, Levitan I, Stifani S, Dressler GR (2003) Groucho suppresses Pax2 transactivation by inhibition of JNK-mediated phosphorylation. EMBO J 22:5522-5529. (Pubitemid 37279961)
13. Hurtado A, et al. (2008) Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen. Nature 456:663-666.
14. Hentschke M, Borgmeyer U (2003) Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma. Biochem Biophys Res Commun 312:975-982. (Pubitemid 37490911)
15. Fisher AL, Caudy M (1998) Groucho proteins: Transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates. Genes Dev 12:1931-1940. (Pubitemid 28323867)
16. Shang Y, Hu X, DiRenzo J, Lazar MA, Brown M (2000) Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 103:843-852.
17. Carroll JS, et al. (2006) Genome-wide analysis of estrogen receptor binding sites. Nat Genet 38:1289-1297. (Pubitemid 44646291)
18. Zhang Y, et al. (2008) Model-based Analysis of ChIP-Seq (MACS). Genome Biol 9: R137-R137.9.
19. Narita M, et al. (2006) A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell 126:503-514. (Pubitemid 44163608)
20. Prall OW, Rogan EM, Musgrove EA, Watts CK, Sutherland RL (1998) c-Myc or cyclin D1 mimics estrogen effects on cyclin E-Cdk2 activation and cell cycle reentry. Mol Cell Biol 18:4499-4508. (Pubitemid 28343034)
21. Musgrove EA, et al. (2008) Identification of functional networks of estrogen- and c-Myc-responsive genes and their relationship to response to tamoxifen therapy in breast cancer. PLoS One 3:e2987.
22. Eeckhoute J, et al. (2009) Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers. Genome Res 19:372-380.
23. Schmidt D, et al. (2009) ChIP-seq: Using high-throughput sequencing to discover protein-DNA interactions. Methods 48:240-248.
24. Dunning MJ, Smith ML, Ritchie ME, Tavare S (2007) beadarray: R classes and methods for Illumina bead-based data. Bioinformatics 23:2183-2184. (Pubitemid 47394121)
25. Cairns JM, Dunning MJ, Ritchie ME, Russell R, Lynch AG (2008) BASH: A tool for managing BeadArray spatial artefacts. Bioinformatics 24:2921-2922.
26. Gentleman RC, et al. (2004) Bioconductor: Open software development for computational biology and bioinformatics. Genome Biol 5:R80-R80.16.
27. Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: A practical and powerful approach to multiple testing. J R Stat Soc Series B Stat Methodol 57:289-300.