Antiproliferative and uncoupling effects of delocalized, lipophilic, cationic gallic acid derivatives on cancer cell lines. Validation in vivo in singenic mice

Journal of Medicinal Chemistry

Volumn 57, Issue 6, 2014, Pages 2440-2454

  Jara, José A ^a   Castro Castillo, Vicente ^c   Saavedra Olavarría, Jorge ^c   Peredo, Liliana ^a   Pavanni, Mario ^a   Jaña, Fabián ^a   Letelier, María Eugenia ^b   Parra, Eduardo ^d   Becker, María Inés ^e   Morello, Antonio ^a   Kemmerling, Ulrike ^a   Maya, Juan Diego ^a   Ferreira, Jorge ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

^c UNIVERSIDAD METROPOLITANA DE CIENCIAS DE LA EDUCACIÓN   (Chile)

^d UNIVERSIDAD DE TARAPACÁ   (Chile)

^e Development of Science and Technology Foundation (FUCITED)   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALKYL GROUP; ANTINEOPLASTIC AGENT; CARBON; GALLIC ACID DERIVATIVE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRIPHENYLPHOSPHONIUM; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VIVO STUDY; LIPOPHILICITY; MALE; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATION; OXYGEN CONSUMPTION; PROTEIN EXPRESSION; SURVIVAL RATE; YOUNG ADULT;

ADENOSINE TRIPHOSPHATE; ANALYSIS OF VARIANCE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASE INHIBITORS; CATIONS; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; GALLIC ACID; HUMANS; L-LACTATE DEHYDROGENASE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIAL SWELLING; NADP; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; REPRODUCIBILITY OF RESULTS; UNCOUPLING AGENTS;

EID: 84897425340     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500174v     Document Type: Article

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