Novel photosensitizers trigger rapid death of malignant human cells and rodent tumor transplants via lipid photodamage and membrane permeabilization

PLoS ONE

Volumn 5, Issue 9, 2010, Pages 1-13

  Moisenovich, Mikhail M ^a   Ol'Shevskaya, Valentina A ^b   Rokitskaya, Tatyana I ^a   Ramonova, Alla A ^a   Nikitina, Roza G ^c   Savchenko, Arina N ^b   Tatarskiy Jr , Victor V ^d   Kaplan, Mikhail A ^c   Kalinin, Valery N ^b   Kotova, Elena A ^a   Uvarov, Oleg V ^e   Agapov, Igor I ^f   Antonenko, Yuri N ^a   Shtil, Alexander A ^d  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b A N NESMEYANOV INSTITUTE OF ORGANOELEMENT COMPOUNDS   (Russian Federation)

^c MEDICAL RADIOLOGICAL RESEARCH CENTER   (Russian Federation)

^d N N BLOKHIN RUSSIAN CANCER RESEARCH CENTER   (Russian Federation)

^e PROKHOROV GENERAL PHYSICS INSTITUTE   (Russian Federation)

^f SHUMAKOV NATIONAL MEDICAL RESEARCH CENTER OF TRANSPLANTOLOGY AND ARTIFICIAL ORGANS   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORIN E6 13(1) N (2 AMINOETHYL)AMIDE 15(2),17(3) DIMETHYL ESTER; CHLORIN E6 13(1) N [2 [N (1 CARBA CLOSO DODECABORAN 1 YL)METHYL]AMINOETHYL]AMIDE 15(2),17(3) DIMETHYL ESTER SODIUM; LIPID; PHOTOSENSITIZING AGENT; PROPIDIUM IODIDE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL DEATH; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; LIPID BILAYER; LYSOSOME; MELANOMA; MEMBRANE CURRENT; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; RAT; RED LIGHT; SARCOMA; ANIMAL; APOPTOSIS; C57BL MOUSE; CANCER TRANSPLANTATION; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; DISEASE MODEL; DRUG EFFECT; FEMALE; LIPID METABOLISM; MALE; METABOLISM; NEOPLASM; PATHOLOGY; PATHOPHYSIOLOGY; PHOTOCHEMOTHERAPY; TUMOR CELL LINE;

MAMMALIA; RODENTIA;

ANIMALS; APOPTOSIS; CELL DEATH; CELL LINE, TUMOR; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; LIPID METABOLISM; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; NEOPLASM TRANSPLANTATION; NEOPLASMS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; RATS; REACTIVE OXYGEN SPECIES;

EID: 77958571344     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012717     Document Type: Article

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