Loss of the mitochondrial bioenergetic capacity underlies the glucose avidity of carcinomas

Cancer Research

Volumn 67, Issue 19, 2007, Pages 9013-9017

  López Ríos, Fernando ^a   Sánchez Aragó, María ^b   García Garía, Elena ^a   Ortega, Álvaro D ^b   Berrendero, José R ^c   Pozo Rodríguez, Francisco ^a   López Encuentra, Ángel ^a   Ballestín, Claudio ^a   Cuezva, José M ^b,c  

^a HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^b CSIC   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GLUCOSE; OLIGOMYCIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ADULT; AGED; ARTICLE; BIOENERGY; CONTROLLED STUDY; FEMALE; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LUNG CARCINOMA; MAJOR CLINICAL STUDY; MALE; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL RESPIRATION; OXIDATIVE PHOSPHORYLATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

ADULT; AEROBIOSIS; AGED; AGED, 80 AND OVER; BLOOD GLUCOSE; CARCINOMA, NON-SMALL-CELL LUNG; ENERGY METABOLISM; FEMALE; FLUORODEOXYGLUCOSE F18; GLUCOSE; GLYCOLYSIS; HCT116 CELLS; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; MITOCHONDRIA; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; OXIDATIVE PHOSPHORYLATION; POSITRON-EMISSION TOMOGRAPHY;

EID: 35148889082     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-1678     Document Type: Article

References (20)

1. Rigo P, Paulus P, Kaschten BJ, et al. Oncological applications of positron emission tomography with fluorine-18 fluorodeoxyglucose. Eur J Nucl Med 1996;23:1641-74.
2. Warburg O. On respiratory impairment in cancer cells. Science 1956;124:269-70.
3. Garber K. Energy deregulation: licensing tumors to grow. Science 2006;312:1158-9.
4. Cuezva JM, Krajewska M, de Heredia ML, et al. The bioenergetic signature of cancer: a marker of tumor progression. Cancer Res 2002;62:6674-81.
5. Isidoro A, Casado E, Redondo A, et al. Breast carcinomas fulfill the Warburg hypothesis and provide metabolic markers of cancer prognosis. Carcinogenesis 2005;26:2095-104.
6. Cuezva JM, Chen G, Alonso AM, et al. The bioenergetic signature of lung adenocarcinomas is a molecular marker of cancer diagnosis and prognosis. Carcinogenesis 2004;25:1157-63.
7. Shin YK, Yoo BC, Chang HJ, et al. Down-regulation of mitochondrial F1F0-ATP synthase in human colon cancer cells with induced 5-fluorouracil resistance. Cancer Res 2005;65:3162-70.
8. 18F]fluorodeoxyglucose positron emission tomography for identifying lymph node mediastinal metastases in potentially respectable non-small-cell lung cancer. J Clin Oncol 2005;23:8348-56.
9. Rossignol R, Gilkerson R, Aggeler R, Yamagata K, Remington SJ, Capaldi RA. Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells. Cancer Res 2004;64:985-93.
10. Govindarajan B, Sligh JE, Vincent BJ, et al. Overexpression of Akt converts radial growth melanoma to vertical growth melanoma. J Clin Invest 2007;117:719-29.
11. 18F] Fluorodeoxyglucose uptake by positron emission tomography predicts outcome of non-small-cell lung cancer. J Clin Oncol 2005;23:1136-43.
12. Semenza GL, Artemov D, Bedi A, et al. "The metabolism of tumours": 70 years later. Novartis Found Symp 2001;240:251-60.
13. Kim JW, Dang CV. Cancer's molecular sweet tooth and the Warburg effect. Cancer Res 2006;66:8927-30.
14. Osthus RC, Shim H, Kim S, et al. Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J Biol Chem 2000;275:21797-800.
15. Matoba S, Kang JG, Patino WD, et al. p53 regulates mitochondrial respiration. Science 2006;312:1650-3.
16. Polyak K, Li Y, Zhu H, et al. Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat Genet 1998;20:291-3.
17. Baysal BE, Ferrell RE, Willett-Brozick JE, et al. Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Science 2000;287:848-51.
18. Wang T, Marquardt C, Foker J. Aerobic glycolysis during lymphocyte proliferation. Nature 1976;261:702-5.
19. Sakamaki T, Casimiro MC, Ju X, et al. Cyclin d1 determines mitochondrial function in vivo. Mol Cell Biol 2006;26:5449-69.
20. Martinez-Diez M, Santamaria G, Ortega AD, Cuezva JM. Biogenesis and dynamics of mitochondria during the cell cycle: significance of 3′UTRs. PLoS ONE 2006;1:e107.