Brain distribution of 6-mercaptopurine is regulated by the efflux transport system in the blood-brain barrier

Life Sciences

Volumn 66, Issue 7, 2000, Pages 649-662

  Deguchi, Yoshiharu ^a   Yokoyama, Yoshinari ^a   Sakamoto, Tatsuichiro ^b   Hayashi, Hideki ^a   Naito, Takafumi ^a   Yamada, Shizuo ^a   Kimura, Ryohei ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b SHIZUOKA CHILDREN'S HOSPITAL   (Japan)

Author keywords

6 mercaptopurine; Blood brain barrier; Efflux transport; Microdialysis

Indexed keywords

MERCAPTOPURINE; N ETHYLMALEIMIDE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CANCER CHEMOTHERAPY; DRUG PROTEIN BINDING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; MALE; MICRODIALYSIS; NONHUMAN; RAT; TISSUE DISTRIBUTION;

6-MERCAPTOPURINE; ANIMALS; BLOOD PROTEINS; BLOOD-BRAIN BARRIER; BRAIN; ETHYLMALEIMIDE; MALE; METABOLIC CLEARANCE RATE; MICRODIALYSIS; PROBENECID; PROTEIN BINDING; RATS; RATS, WISTAR;

EID: 0034614361     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(99)00637-2     Document Type: Article

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