Monocarboxylic acid transporters, MCT1 and MCT2, in cortical astrocytes in vitro and in vivo

American Journal of Physiology - Cell Physiology

Volumn 278, Issue 5 47-5, 2000, Pages

  Hanu, Rekha ^a   McKenna, Mary ^a   O'Neill, Andrea ^a   Resneck, Wendy G ^a   Bloch, Robert J ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

Blood brain barrier; Immunofluorescence; Lactate 660; Plasma membrane

Indexed keywords

CARBOXYLIC ACID; CARRIER PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN;

ANIMAL CELL; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; CELL MEMBRANE; CONTROLLED STUDY; CYTOPLASM; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT;

ANIMALIA;

EID: 0034041755     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.2000.278.5.c921     Document Type: Article

References (11)

1. 13C]aspartate in cultured astrocytes: compartmentation of pyruvate metabolism. Neurosci Lett 237: 117-120, 1997.
2. Bittar PG, Charnay Y, Pellerin L, Bouras C, and Magistretti PJ. Selective distribution of lactate dehydrogenase isozymes in neurons and astrocytes of human brain. J Cereb Blood Flow Metab 16: 1079-1089, 1996.
3. Bixel G and Hamprecht B. Generation of ketone bodies from leucine by cultured astroglial cells. J Neurochem 65: 2450-2461, 1995.
4. Broer S, Rohman B, Pellegri G, Pellerin L, Martin JL, Verleysdonk S, Hamprecht B, and Magistretti PJ. Comparison of lactate transport in astroglial cells and monocarboxylate transporter l (MCT1) expressing Xenopus laevis oocytes. J Biol Chem 272: 30096-30102, 1997.
5. Busch GL, Wiesinger H, Gulbins E, Wagner HJ, Hamprecht B, and Lang F. Effect of astroglial cell swelling on pH of acidic intracellular compartments. Biochim Biophys Acta 1285: 212-218, 1996.
6. Cesar M and Hamprecht B. Immunocytochemical examination of neural rat and mouse primary cultures using monoclonal antibodies raised against pyruvate carboxylase. J Neurochem 64: 2312-2318, 1995.
7. Dombrowski GJ Jr, Swiatek KR, and Chao KL. Lactate, 3-hydroxybutyrate, and glucose as substrates for early postnatal rat brain. Neurochem Res 14: 667-675, 1989.
8. Dringen R, Gebhardt R, and Hamprecht B. Glycogen in astrocytes: possible function as lactate supply for neighboring cells. Brain Res 623: 208-214, 1993.
9. Dringen R, Wiesenger H, and Hamprecht B. Uptake of L-lactate by cultured rat brain neurons. Neurosci Lett 163: 5-7, 1993.
10. Edmond J, Bobbins RA, Bergstrom JD, Cole RA, and de Vellis J. Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture. J Neurosci Res 18: 551-561, 1987.
11. Farrell CL and Pardridge WM. Blood-brain barrier glucose transporter is asymmetrically distributed on brain capillary endothelial lumenal and ablumenal membranes: an electron microscopic immunogold study. Proc Natl Acad Sci USA 88: 5779-5783, 1991.