A novel postsynaptic density protein: The monocarboxylate transporter MCT2 is co-localized with δ-glutamate receptors in postsynaptic densities of parallel fiber-Purkinje cell synapses

Experimental Brain Research

Volumn 137, Issue 1, 2001, Pages 523-534

  Bergersen, Linda ^b   Wærhaug, Ola ^b   Helm, Johannes ^b   Thomas, Marion ^b   Laake, Petter ^b   Davies, Andrew J ^b   Wilson, Mariangela C ^b   Halestrap, Andrew P ^b   Ottersen, Ole P ^b  

^a UNIVERSITY OF OSLO   (Norway)

^b NONE

Author keywords

Cerebellum; Glutamate receptors; Immunocytochemistry; Monocarboxylate transporters; Parallel fiber spine synapses

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; GLUTAMATE RECEPTOR; ION CHANNEL; MOLECULE TRANSPORT AGENT; MONOCARBOXYLATE TRANSPORTER 2; UNCLASSIFIED DRUG; ANTIBODY; CARRIER PROTEIN; GLUTAMATE RECEPTOR DELTA 2; MONOCARBOXYLATE TRANSPORTER; SLC16A7 PROTEIN, RAT;

ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; CEREBELLUM; CONFOCAL MICROSCOPY; CYTOCHEMISTRY; ENDOTHELIUM CELL; ENERGY; GLIA; IMMUNOFLUORESCENCE; IMMUNOGOLD STAINING; MALE; NERVE CELL EXCITABILITY; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PURKINJE CELL; RAT; SIGNAL TRANSDUCTION; SYNAPTIC MEMBRANE; ANIMAL; CHEMISTRY; IMMUNOBLOTTING; IMMUNOELECTRON MICROSCOPY; IMMUNOLOGY; SYNAPSE; ULTRASTRUCTURE; WISTAR RAT;

ANIMALS; ANTIBODIES; CARRIER PROTEINS; IMMUNOBLOTTING; MALE; MICROSCOPY, IMMUNOELECTRON; MONOCARBOXYLIC ACID TRANSPORTERS; PURKINJE CELLS; RATS; RATS, WISTAR; RECEPTORS, GLUTAMATE; SYNAPSES;

EID: 0035114149     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002210000600     Document Type: Article

References (50)

1. + exchanger (NHE5) highly expressed in brain
2. Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes
3. Glutamate transporters in glial plasma membranes: Highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry
4. PDZ proteins organize synaptic signaling pathways
5. The high affinity uptake system for excitatory amino acids in the brain
6. The glutamate transporter EAAT4 in rat cerebellar Purkinje cells: A glutamate-gated chloride channel concentrated near the synapse in parts of the dendritic membrane facing astroglia
7. cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13-2-p12
8. cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1
9. Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats
10. Expression of the monocarboxylate transporter MCT2 by rat brain glia
11. Purification and characterization of a calmodulin-dependent kinase from rat brain cytosol able to phosphorylate tubulin and microtubule-associated proteins
12. Transport of lactate and other monocarboxylates across mammalian plasma membranes
13. The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation
14. Stability of GLUT-1 and GLUT-4 expression in perfused rat muscle stimulated by insulin and exercise
15. Glial formation of pyruvate and lactate from TCA cycle intermediates: Implications for the inactivation of transmitter amino acids?
16. Antisera to glutathione: Characterization and immunocytochemical application to the rat cerebellum
17. Anchoring of glutamate receptors at the synapse
18. Cloning of the monocarboxylate transporter isoform MCT2 from rat testis provides evidence that expression in tissues is species-specific and may involve post-transcriptional regulation
19. Lactate transport in skeletal muscle - Role and regulation of the monocarboxylate transporter
20. The postsynaptic density at glutamatergic synapses
21. Signal transduction molecules at the glutamatergic postsynaptic membrane
22. Biochemical and immunochemical evidence that the "major postsynaptic density protein" is a subunit of a calmodulin-dependent protein kinase
23. CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression
24. Monocarboxylate transporter expression in mouse brain
25. Differential localization of delta glutamate receptors in the rat cerebellum: Co-expression with AMPA receptors in parallel fiber-spine synapses and absence from climbing fiber-spine synapses
26. + exchangers in rat central nervous system
27. Energy on demand
28. Organization of AMPA receptor subunits at a glutamate synapse: A quantitative immunogold analysis of hair cell synapses in the rat organ of Corti
29. Immunoprecipitation, immunoblotting, and immunocytochemistry studies suggest that glutamate receptor delta subunits form novel post-synaptic receptor complexes
30. Role of the lactate transporter (MCT1) in skeletal muscles
31. +-channel proteins in the rat brain
32. Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells
33. Metabolic compartmentation of glutamate and glutamine: Morphological evidence obtained by quantitative immunocytochemistry in rat cerebellum
34. Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization
35. +-ATPase activity in astrocytes via activation of a distinct subunit highly sensitive to ouabain
36. Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle
37. Expression of mono-carboxylate transporter mRNAs in mouse brain: Support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain
38. Monocarboxylate transporter MCT1 is located in the apical membrane and MCT3 in the basal membrane of rat RPE
39. Lactate released by Muller glial cells is metabolized by photoreceptors from mammalian retina
40. +/lactate cotransporter (MCT1)
41. Postsynaptic density-93 interacts with the delta2 glutamate receptor subunit at parallel fiber synapses
42. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis
43. Glutamate receptor anchoring proteins and the molecular organization of excitatory synapses
44. Freeze-substitution and Lowicryl HM20 embedding of fixed rat brain: Suitability for immunogold ultrastructural localization of neural antigens
45. Immunohistochemistry localization of dopamine D1 receptors in rat retina
46. Simultaneous demonstration of multiple antigens by indirect immunofluorescence or immunogold staining. Novel light and electron microscopical double and triple staining method employing primary antibodies from the same species
47. Immunochemi-cal characterization of the non-NMDA glutamate receptor using subunit-specific antibodies. Evidence for a hetero-oligomeric structure in rat brain
48. Lactic acid efflux from white skeletal muscle is catalyzed by the monocarboxylate transporter isoform MCT3
49. Delta-glutamate receptors are differentially distributed at parallel and climbing fiber synapses on Purkinje cells