Tetrandrine blocks autophagic flux and induces apoptosis via energetic impairment in cancer cells

Cell Death and Disease

Volumn 5, Issue 3, 2014, Pages

  Qiu, W ^a,b   Su, M ^c   Xie, F ^a,b   Ai, J ^d   Ren, Y ^a   Zhang, J ^a,b   Guan, R ^a,b   He, W ^e   Gong, Y ^a,b   Guo, Y ^a,b  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b NATIONAL UROLOGICAL CANCER CENTER   (China)

^c PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

Author keywords

Apoptosis; Autophagy; Lysosomes; Metabolism; Tetrandrine

Indexed keywords

3 METHYLADENINE; BECLIN 1; CASPASE 3; GLUCOSE; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3 TYPE II; PROTEIN; PYRUVIC ACID; SC 201492; SEQUESTOSOME 1; TETRANDRINE; TRICARBOXYLIC ACID; UNCLASSIFIED DRUG;

ACIDITY; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CELL ENERGY; CONTROLLED STUDY; ENZYME ACTIVATION; GENE SILENCING; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LYSOSOME; MALE; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; TUMOR XENOGRAFT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BENZYLISOQUINOLINES; CASPASE 3; CITRIC ACID CYCLE; ENERGY METABOLISM; FEMALE; GLUCOSE; HELA CELLS; HEP G2 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; LYSOSOMES; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, NUDE; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASMS; OXIDATIVE PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84897406550     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.84     Document Type: Article

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