Tetrandrine induces apoptosis by activating reactive oxygen species and repressing Akt activity in human hepatocellular carcinoma

International Journal of Cancer

Volumn 129, Issue 6, 2011, Pages 1519-1531

  Liu, Chaoyang ^a   Gong, Ke ^a   Mao, Xin ^a   Li, Wenhua ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Akt; apoptosis; HCC; ROS; tetrandrine

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TETRANDRINE;

ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL STRUCTURE; CHROMATIN; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DNA FRAGMENTATION; DOSE RESPONSE; DRUG EFFICACY; DRUG MEGADOSE; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; LOW DRUG DOSE; MALE; MONOTHERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK REDUCTION; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BENZYLISOQUINOLINES; CARCINOMA, HEPATOCELLULAR; CASPASES; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; ENZYME ACTIVATION; HUMANS; LIVER NEOPLASMS; MALE; MICE; MICE, NUDE; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79959757676     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25817     Document Type: Article

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