Tetrandrine: A potent abrogator of G2 checkpoint function in tumor cells and its mechanism

Biomedical and Environmental Sciences

Volumn 20, Issue 6, 2007, Pages 495-501

  Sun, Xin Chen ^a,c   Cheng, Hong Yan ^a   Deng, Yu Xia ^a   Shao, Rong Guang ^b   Ma, Jun ^a  

^a SOUTHEAST UNIVERSITY   (China)

^b INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

^c AFFILIATED ZHONGDA HOSPITAL OF SOUTHEAST UNIVERSITY   (China)

Author keywords

Breast cancer cell line MCF 7; Breast cancer cell line MCF 7 ADR; Cell cycle; Colon carcinoma C26 BALB c mice; Colon carcinoma cell line HT 29; Irradiation; P53; Tetrandrine; Western blotting

Indexed keywords

BENZYLISOQUINOLINE DERIVATIVE; CYCLIN B; CYCLIN B1; CYCLIN DEPENDENT KINASE; TETRANDRINE;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CELL CYCLE G2 PHASE; DRUG EFFECT; DRUG SCREENING; HUMAN; MALE; METABOLISM; MOUSE; RADIATION DOSE; TUMOR CELL LINE;

ANIMALS; BENZYLISOQUINOLINES; CDC2-CDC28 KINASES; CELL LINE, TUMOR; CYCLIN B; DRUG SCREENING ASSAYS, ANTITUMOR; G2 PHASE; HUMANS; MALE; MICE; MICE, INBRED BALB C; RADIATION TOLERANCE;

MUS;

EID: 38949179119     PISSN: 08953988     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Sherr C J (1996). Cancer cell cycles. Science 274, 1672-1677.
2. Iliakis G, Wang Y, Guan J, et al. (2003). DNA damage checkpoint control in cells exposes to ionizing radiation. Oncogene 22, 5834-5847.
3. Roninson I B, Broude E V, Chang B D (2001). If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist Updates 4, 303-313.
4. 2 checkpoint. EMBO J17, 2728-2735.
5. 2/M DNA damage checkpoint. Genes Dev 14, 1448-1459.
6. Kastan M B, Lim D S, Kim S T, et al. (2000). Multiple signaling pathways involving ATM. Cold Spring Harb Symp Quant Biol 65, 521-526.
7. Shen Y C, Chou C J, Chiou W F, et al. (2001). Anti-inflammatory effects of the partially purified extract of radix Stephaniae tetrandrae: comparative atudies of its active principles tetrandrine and fangchinoline on human polymorphonuclear leukocyte functions. Mol Pharmacol 60, 1083-1090.
8. Chang K H, Chen M L, Chen H C (1999). Enhancement of radiosensitivity in human gliblastoma U138MG cells by tetrandrine. Neoplasma 46(3), 196-200.
9. Liu N, Zheng X L (1985). Effects of misonidazole and tetrandrine on production and repair of radiation-induced DNA damage in L7712 cells. Zhongguo Yao Li Xue Bao 6(3), 209-213.
10. Xu H P, Wang C Y, Zhu H C, et al. (1995). The effect of tetrandrine and radiation on retinoblastoma cell line HXO-Rb44. Zhongguo Shi Yong Yon Ke Za Zhi 13(11), 668-670. (In Chinese)
11. Gao L S (1980). Study on the effect of Tet and low-dose-rate radiotherapy in lung carcinoma. Journal of Traditional Chinese Medicine 8, 37-39. (In Chinese)
12. O'Connor P M, Kohn K W (1992). A fundamental role for cell cycle regulation in the chemosensitivity of cancer cells? Semin Cancer Biol 3, 409-416.
13. Hartwell L H, Weinert T A (1989). Checkpoints: controls that ensure the order of cell cycle events. Science 246, 629-634.
14. Lau C C, Pardee A B (1982). Mechanism by which caffeine potentiates lethality of nitrogen mustard. Proc Natl Acad Sci USA 79, 2942-2946.
15. Weinert T A, Hartwekk L H (1988). The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science 241, 317-322.
16. O'Connor P M, Kohn K W (1992). A fundamental role for cell cycle regulation in the chemosensitivity of cancer cells? Semin Cancer Biol 3, 409-416.
17. Hartwell L H, Weinert T A (1989). Checkpoints: controls thatensure the order of cell cycle events. Science 246, 629-634.
18. Nurse P (1994). Ordering S phase and M phase in the cell cycle. Cell 79, 547-550.
19. Desai D, Wessling H C, Fisher R P, et al. (1995). Effects of phosphorylation by CAK on cyclin binding by Cdc2 and CDK2. MoI Cell Biol 15, 345-350.
20. Pagano M, Peperkof R, Verde F, et al. (1992). Cyclin A is required at two points in the human cell cycle. EMBO J 11, 961-971.
21. Graves P R, Yu L J, Schwarz J K, et al. (2000). The Chkl protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. The Journal of Biological Chemistry 275(8), 5600-5605.
22. Sherr C J (1994). G1 phase progression: cycling on cue. Cell 79, 551-555.
23. Narayanan P K, Rudnick J M, Walthers E A, et al. (1997). Modulation in cell cycle and cyclin B1 expression in irradiated HeLa cells and normal human skin fibroblasts treated with staurosporine and caffeine. Exp Cel Res 233, 118-127.
24. Akinaga S, Nomura K, Gomi K, et al. (1994). Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma A431 cells. Cancer Chemother Pharmacol 33, 273-280.
25. 2 delay in human brain tumor cells after treatment with camptothecin. Neuro-Oncology 3, 11-21.