Leptin downregulates LPS-induced lung injury: Role of corticosterone and insulin

Cellular Physiology and Biochemistry

Volumn 33, Issue 3, 2014, Pages 835-846

  Landgraf, Maristella A ^a,b   Silva, Reinaldo C ^b   Corrêa Costa, Matheus ^a   Hiyane, Meire I ^a   Carvalho, Maria Helena C ^a   Landgraf, Richardt G ^a,b   Câmara, Niels O S ^a,b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Insulin, corticosterone, acute lung injury; Leptin; Lipopolysaccharide; Lung inflammation

Indexed keywords

CORTICOSTERONE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; INTERCELLULAR ADHESION MOLECULE 1; LEPTIN; LIPOPOLYSACCHARIDE; RANTES; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; CYTOKINE; ICAM1 PROTEIN, MOUSE; NOS2 PROTEIN, MOUSE; KERATINOCYTE DERIVED CHEMOKINE;

ACUTE LUNG INFLAMMATION; ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; HISTOPATHOLOGY; HORMONE SYNTHESIS; INFLAMMATION; LUNG LAVAGE; LUNG PARENCHYMA; LYMPHOCYTE; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED; METABOLISM; PATHOLOGY; ANIMAL CELL; LUNG INJURY; NEUTROPHIL COUNT; PNEUMONIA;

ANIMALIA; MUS;

ACUTE LUNG INJURY; ANIMALS; CORTICOSTERONE; CYTOKINES; INSULIN; INTERCELLULAR ADHESION MOLECULE-1; LEPTIN; LIPOPOLYSACCHARIDES; MALE; MICE; NITRIC OXIDE SYNTHASE TYPE II;

EID: 84897117941     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000358656     Document Type: Article

References (50)

1. Abraham E, Carmody A, Shenkar R, Arcaroli J: Neutrophils as early immunologic effectors in hemorrhage-or endotoxemia-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol 2000;279:L1137-1145.
2. Ware LB, Matthay MA: The Acute Respiratory Distress Syndrome. N Engl J Med 2000;342:1334-1349.
3. Uchiba M, Okajima K, Murakami K, Johno M, Okabe H, Takatsuki K: Attenuation of endotoxin-induced pulmonary vascular injury by antithrombin III. Am J Physiol 1996;270:L921-930.
4. Kabir K, Gelinas JP, Chen M, Chen D, Zhang D, Luo X, Yang JH, Carter D, Rabinovici R: Characterization of a murine model of endotoxin-induced acute lung injury. Shock 2002;17:300-303.
5. Sato K, Kadiiska MB, Ghio AJ, Corbett J, Fann YC, Holland SM, Thurman RG, Mason RP: In vivo lipid derived free radical formation by NADPH oxidase in acute lung injury induced by lipopolysaccharide: a model for ARDS. FASEB J 2002;16:1713-1720.
6. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-432.
7. Ahima RS, Flier JS: Leptin. Annu Rev Physiol 2000;62:413-437.
8. Faggioni R, Feingold KR, Grunfeld C: Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J 2001;15:2565-2571.
9. La Cava A, Matarese G: The weight of leptin in immunity. Nat Rev Immunol 2004;4:371-379.
10. Grunfeld C, Zhao C, Fuller J, Pollack A, Moser A, Friedman J, Feingold KR: Endotoxin and Cytokines Induce Expression of Leptin, the ob Gene Product, in Hamsters. J Clin Invest 1996;97:2152-2157.
11. Bruno A, Pace E, Chanez P, Gras D, Vachier I, Chiappara G, La Guardia M, Gerbino S, Profita M, Gjomarkaj M: Leptin and leptin receptor expression in asthma. J Allergy Clin Immunol 2009;124:230-237.
12. Assad NA, Sood A: Leptin, adiponectin and pulmonary diseases. Biochimie 2012;94:2180-2189.
13. Ubags ND, Vernooy JH, Burg E, Hayes C, Bement J, Dilli E, Zabeau L, Abraham E, Poch KR, Nick JA, Dienz O, Zuñiga J, Wargo MJ, Mizgerd JP, Tavernier J, Rincón M, Poynter ME, Wouters EF, Suratt BT: The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury. Crit Care Med 2014;42:e143-151.
14. Faggioni R, Fantuzzi G, Gabay C, Moser A, Dinarello CA, Feingold KR, Grunfeld C: Leptin deficiency enhances sensitivity to endotoxin induced lethality. Am J Physiol 1999;276:R136-142.
15. Madiehe AM, Mitchell TD, Harris RB: Hyperleptinemia and reduced TNF-alpha secretion cause resistance of db/db mice to endotoxin. Am J Physiol Regul Integr Comp Physiol 2003;284:R763-770.
16. Gultekin FA, Kerem M, Tatlicioglu E, Aricioglu A, Unsal C, Bukan N: Leptin treatment ameliorates acute lung injury in rats with cerulein-induced acute pancreatitis. World J Gastroenterol 2007;13:2932-2938.
17. Dong HY, Xu M, Ji ZY, Wang YX, Dong MQ, Liu ML, Xu DQ, Zhao PT, Liu Y, Luo Y, Niu W, Zhang B, Ye J, Li ZC: Leptin attenuates lipopolysaccharide or oleic Acid-induced acute lung injury in mice. Am J Respir Cell Mol Biol. 2013;49:1057-1063.
18. Pradelles P, Grassi J, Maclouf J: Enzyme immunoassays of eicosanoids using acetylcholine esterase as label: an alternative to radioimmunoassay. Anal Chem 1985;57:1170-1173.
19. Vernooy JH, Dentener MA, van Suylen RJ, Buurman WA, Wouters EF: Intratracheal Instillation of Lipopolysaccharide in Mice Induces Apoptosis in Bronchial Epithelial Cells No Role for Tumor Necrosis Factor-aand Infiltrating Neutrophils. Am J Resp Cell Mol Biol 2001;24:569-576.
20. Morris PE, Glass J, Cross R, Cohen DA: Role of T-lymphocytes in the resolution of endotoxin-induced lung injury. Inflammation 1997;21:269-278.
21. Pham CT: Neutrophil serine proteases: specific regulators of inflammation. Nat Rev Immunol 2006;6:541-550.
22. Grommes J, Soehnlein O: Contribution of Neutrophils to Acute Lung Injury. Mol Med 2011;17:293-307.
23. Nick JA, Young SK, Brown KK, Avdi NJ, Arndt PG, Suratt BT, Janes MS, Henson PM, Worthen GS: Role of p38 mitogen-activated protein kinase in a murine model of pulmonary inflammation. J Immunol 2000;164:2151-2159.
24. Matthay MA, Zimmerman GA: Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management. Am J Respir Cell Mol Biol 2005;33:319-327.
25. VanderMeer TJ, Menconi MJ, O'Sullivan BP, Larkin VA, Wang H, Sofia M, Fink MP: Acute lung injury in endotoxemic pigs: role of leukotriene B4. J Appl Physiol 1995;78:1121-1131.
26. Ito H, Koide N, Hassan F: Lethal endotoxic shock using alpha-galactosylceramide sensitization as a new experimental model of septic shock. Lab Invest 2006;86:254-261.
27. Choi JC, Jung JW, Kwak HW, Song JH, Jeon EJ, Shin JW, Park IW, Choi BW, Kim JY: Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Augments Acute Lung Injury via Its Neutrophil Priming Effects. J Korean Med Sci 2008;23:288-295.
28. Silberstein DS, Owen WF, Gasson JC, DiPersio JF, Golde DW, Bina JC, Soberman R, Austen KF, David JR: Enhancement of human eosinophil cytotoxicity and leukotriene synthesis by biosynthetic (recombinant) granulocyte-macrophage colony-stimulating factor. J Immunol 1986;137:3290-3294.
29. Pickkers P, Sprong T, Eijk Lv, Hoeven Hv, Smits P, Deuren Mv: Vascular endothelial growth factor is increased during the first 48 hours of human septic shock and correlates with vascular permeability. Shock 2005;24:508-512.
30. Kumasaka T, Quinlan WM, Doyle NA, Condon TP, Sligh J, Takei F, Beaudet Al, Bennett CF, Doerschuk CM: Role of the intercellular adhesion molecule-1 (ICAM-1) in endotoxin-induced penumonia evaluated using ICAM-1 antisense oligonucleotides, anti-ICAM-1 monoclonal antibodies and ICAM-1 mutant mice. J Clin Invest 1996;97:2362-2369.
31. Loffreda S, Yang SQ, Lin HZ, Karp CL, Brengman ML, Wang DJ, Klein AS, Bulkley GB, Bao C, Noble PW, Lane MD, Diehl AM: Leptin regulates proinflammatory immune responses. FASEB J 1998;12:57-65.
32. Santos-Alvarez J, Goberna R, Sanchez-Margalet V: Human leptin stimulates proliferation and activation of human circulating monocytes. Cell Immunol 1999;194:6-11.
33. Zarkesh-Esfahani H, Pockley G, Metcalfe RA, Bidlingmaier M, Wu Z, Ajami A, Weetman AP, Strasburger CJ, Ross RJ: High-dose leptin activates human leukocytes via receptor expression on monocytes. J Immunol 2001;167:4593-4599.
34. Bellmeyer A, Martino JM, Chandel NS, Scott Budinger GR, Dean DA, Mutlu GM: Leptin resistance protects mice from hyperoxia-induced acute lung injury. Am J Respir Crit Care Med 2007;175:587-594
35. Xiao E, Xia-Zhang L, Vulliémoz NR, Ferin M, Wardlaw SL: Leptin modulates inflammatory cytokine and neuroendocrine responses to endotoxin in the primate. Endocrinology 2003;144:4350-4353.
36. van der Vliet A, Eiserich JP, Cross CE: Nitric oxide: a proinflammatory mediator in lung disease? Respir Res 2000;1:67-72.
37. Numata M, Suzuki S, Miyazawa N, Miyashita A, Nagashima Y, Inoue S, Kaneko T, Okubo T: Inhibition of iNOS prevents LPS-induced acute lung injury in dogs. J Immunol 1998;160:3031-3037.
38. Trifilieff A, Fujitani Y, Mentz F, Dugas B, Fuentes M, Bertrand C: Inducible nitric oxide synthase inhibitors suppresses airway inflammation in mice through downregulation of chemokine expression. J Immunol 2000;165:1526-1533.
39. de Oliveira Martins J, Meyer-Pflug AR, Alba-Loureiro TC, Melbostad H, Costa da Cruz JW, Coimbra R, Curi R, Sannomiya P: Modulation of lipopolysaccharide-induced acute lung inflammation: role of insulin. Shock 2006;25:260-266.
40. Alba-Loureiro TC, Munhoz CD, Martins JO, Cerchiaro GA, Scavone C, Curi R, Sannomiya P: Neutrophil function and metabolism in individuals with diabetes mellitus. Braz J Med Biol Res 2007;40:1037-1044.
41. Cornell RP: Endogenous gut-derived bacterial endotoxin tonically primes pancreatic secretion secretion of insulin in normal rats. Diabetes 1985;34:1253-1259.
42. Creely SJ, McTernan PG, Kusminski CM, Fisher FM, Da Silva NF, Khanolkar M, Evans M, Harte AL, Kumar S: Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. Am J Physiol Endocrinol Metab 2007;292:E740-747.
43. Fehmann HC, Peiser C, Bode HP, Stamm M, Staats P, Hedetoft C, Lang RE, Göke B: Leptin: a potent inhibitor of insulin secretion. Peptides 1997;18:1267-1273.
44. van Dijk G, Donahey JC, Thiele TE, Scheurink AJ, Steffens AB, Wilkinson CW, Tenenbaum R, Campfield LA, Burn P, Seeley RJ, Woods SC: Central leptin stimulates corticosterone secretion at the onset of the dark phase. Diabetes 1997;46:1911-1914.
45. Malendowicz LK, Macchi C, Nussdorfer GG, Nowak KW: Acute effects of recombinant murine leptin on rat pituitary-adrenocortical function. Endocr Res 1998;24:235-246.
46. Yuen BS, Owens PC, Symonds ME, Keisler DH, McFarlane JR, Kauter KG, McMillen IC: Effects of leptin on fetal plasma adrenocorticotropic hormone and cortisol concentrations and the timing of parturition in the sheep. Biol Reprod 2004;70:1650-1657.
47. McCall AL: Diabetes mellitus and the central nervous system. Int Rev Neurobiol 2002;51:415-453.
48. Spinedi E, Gaillard RC: A regulatory loop between the hypothalamic-pituitary-adrenal (HPA) axis and circulating leptin: a physiological role of ACTH. Endocrinology 1998;9:4016-4020.
49. Chan O, Inouye K, Riddell MC, Vranic M, Matthews SG: Diabetes and the hypothalamic-pituitary-adrenal (HPA) axis. Minerva Endocrinol 2003;28:87-102.
50. Silva PL, Garcia CSNB, Maronas PA, Cagido VR, Negri EM, Damaceno-Rodrigues NR, Ventura GM, Bozza PT, Zin WA, Capelozzi VL, Pelosi P, Rocco PRM: Early short-term versus prolonged low-dose methylprednisolone therapy in acute lung injury. Eur Respir J 2009;33:634-645.