Sustained and selective suppression of intestinal cholesterol synthesis by Ro 48-8071, an inhibitor of 2,3-oxidosqualene:lanosterol cyclase, in the BALB/c mouse

Biochemical Pharmacology

Volumn 88, Issue 3, 2014, Pages 351-363

  Chuang, Jen Chieh ^a   Valasek, Mark A ^b   Lopez, Adam M ^a   Posey, Kenneth S ^a   Repa, Joyce J ^a,c   Turley, Stephen D ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cholesterol absorption; Enterocyte; Ezetimibe; Liver; Statins

Indexed keywords

CASPASE 3; CASPASE 4; CHOLESTANETRIOL 26 MONOOXYGENASE; CYTOCHROME P450 3A11; ENZYME INHIBITOR; EOSIN; HEMATOXYLIN; KI 67 ANTIGEN; LANOSTEROL SYNTHASE; MESSENGER RNA; NIEMANN PICK C1 LIKE 1 PROTEIN; PROTEIN; RO 48 8071; SIMVASTATIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CHOLESTEROL LIVER LEVEL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; FATTY ACID SYNTHESIS; FEMALE; GENE EXPRESSION; GENE TARGETING; HISTOLOGY; LARGE INTESTINE; LIPID ABSORPTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMALL INTESTINE; STEROL EXCRETION; STOMACH;

CHOLESTEROL ABSORPTION; ENTEROCYTE; EZETIMIBE; LIVER; STATINS;

ANIMALS; AZETIDINES; BENZOPHENONES; CHOLESTEROL; DIET; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INTESTINAL MUCOSA; INTESTINE, SMALL; INTRAMOLECULAR TRANSFERASES; LIVER; MALE; MESOCRICETUS; MICE; MICE, INBRED BALB C; RECEPTORS, LDL; SIMVASTATIN; SPECIES SPECIFICITY;

EID: 84897114655     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.01.031     Document Type: Article

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