Reduction of VLDL secretion decreases cholesterol excretion in niemann-pick C1-like 1 hepatic transgenic mice

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Marshall, Stephanie M ^a,c   Kelley, Kathryn L ^a   Davis, Matthew A ^a   Wilson, Martha D ^a   McDaniel, Allison L ^a   Lee, Richard G ^b   Crooke, Rosanne M ^b   Graham, Mark J ^b   Rudel, Lawrence L ^a   Brown, J Mark ^a,c   Temel, Ryan E ^a,d  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b ISIS PHARMACEUTICALS   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CHOLESTEROL; LIVER PROTEIN; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; TRIGLYCERIDE TRANSFER PROTEIN; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL DIET; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; LIPOGENESIS; LIPOPROTEIN SECRETION; LIVER MICROSOME; MALE; MOUSE; NIEMANN PICK C1 LIKE 1 HEPATIC TRANSGENIC MOUSE; NONHUMAN; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; REGULATORY MECHANISM; SMALL INTESTINE; TRANSGENIC MOUSE; TRANSINTESTINAL CHOLESTEROL EFFLUX;

ANIMALS; CARRIER PROTEINS; CHOLESTEROL; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; HEPATOCYTES; LIPOPROTEINS; LIPOPROTEINS, VLDL; LIVER; MALE; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, TRANSGENIC; OLIGORIBONUCLEOTIDES, ANTISENSE; RECEPTORS, LDL;

EID: 84896775958     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084418     Document Type: Article

References (29)

1. Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, et al. (2010) Heart disease and stroke statistics-2010 update: a report from the American Heart Association. Circulation 121: e46-e215.
2. Davis HR, Tershakovec AM, Tomassini JE, Musliner T (2011) Intestinal sterol transporters and cholesterol absorption inhibition. Curr Opin Lipidol 22: 467-478.
3. Khera AV, Rader DJ (2010) Future therapeutic directions in reverse cholesterol transport. Current atherosclerosis reports 12: 73-81.
4. Temel RE, Brown JM (2012) Biliary and nonbiliary contributions to reverse cholesterol transport. Curr Opin Lipidol 23: 85-90.
5. Brufau G, Groen AK, Kuipers F (2011) Reverse cholesterol transport revisited: contribution of biliary versus intestinal cholesterol excretion. Arterioscler Thromb Vasc Biol 31: 1726-1733.
6. van der Veen JN, van Dijk TH, Vrins CL, van Meer H, Havinga R, et al. (2009) Activation of the liver X receptor stimulates trans-intestinal excretion of plasma cholesterol. J Biol Chem 284: 19211-19219.
7. Kruit JK, Plosch T, Havinga R, Boverhof R, Groot PH, et al. (2005) Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice. Gastroenterology 128: 147-156. (Pubitemid 40039966)
8. van der Velde AE, Vrins CL, van den Oever K, Kunne C, Oude Elferink RP, et al. (2007) Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice. Gastroenterology 133: 967-975. (Pubitemid 47374133)
9. Simmonds WJ, Hofmann AF, Theodor E (1967) Absorption of cholesterol from a micellar solution: intestinal perfusion studies in man. J Clin Invest 46: 874-890.
10. Vrins CL, van der Velde AE, van den Oever K, Levels JH, Huet S, et al. (2009) Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux. J Lipid Res 50: 2046-2054.
11. Cheng SH, Stanley MM (1959) Secretion of cholesterol by intestinal mucosa in patients with complete common bile duct obstruction. Proc Soc Exp Biol Med 101: 223-225.
12. van der Velde AE, Vrins CL, van den Oever K, Seemann I, Oude Elferink RP, et al. (2008) Regulation of direct transintestinal cholesterol excretion in mice. Am J Physiol Gastrointest Liver Physiol 295: G203-G208.
13. Temel RE, Sawyer JK, Yu L, Lord C, Degirolamo C, et al. (2010) Biliary sterol secretion is not required for macrophage reverse cholesterol transport. Cell Metab 12: 96-102.
14. Nijstad N, Gautier T, Briand F, Rader DJ, Tietge UJ (2011) Biliary sterol secretion is required for functional in vivo reverse cholesterol transport in mice. Gastroenterology 140: 1043-1051.
15. Temel RE, Tang W, Ma Y, Rudel LL, Willingham MC, et al. (2007) Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe. J Clin Invest 117: 1968-1978. (Pubitemid 47036331)
16. Vrins CL, Ottenhoff R, van den Oever K, de Waart DR, Kruyt JK, et al. (2012) Trans-intestinal cholesterol efflux is not mediated through high density lipoprotein. J Lipid Res 53: 2017-2023.
17. Plosch T, Kok T, Bloks VW, Smit MJ, Havinga R, et al. (2002) Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1. J Biol Chem 277: 33870-33877.
18. Hussain MM, Shi J, Dreizen P (2003) Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly. J Lipid Res 44: 22-32. (Pubitemid 36114766)
19. Alger HM, Brown JM, Sawyer JK, Kelley KL, Shah R, et al. (2010) Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization. J Biol Chem 285: 14267-14274.
20. Lee RG, Fu W, Graham MJ, Mullick AE, Sipe D, et al. (2013) Comparison of the Pharmacological Profiles of Murine Antisense Oligonucleotides Targeting Apolipoprotein B and Microsomal Triglyceride Transfer Protein. J Lipid Res 54: 602-614.
21. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275.
22. Rayner KJ, Esau CC, Hussain FN, McDaniel AL, Marshall SM, et al. (2011) Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides. Nature 478: 404-407.
23. Temel RE, Lee RG, Kelley KL, Davis MA, Shah R, et al. (2005) Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2. J Lipid Res 46: 2423-2431. (Pubitemid 41532530)
24. Millar JS, Cromley DA, McCoy MG, Rader DJ, Billheimer JT (2005) Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339. J Lipid Res 46: 2023-2028. (Pubitemid 41248500)
25. Chung S, Timmins JM, Duong M, Degirolamo C, Rong S, et al. (2010) Targeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism. J Biol Chem 285: 12197-12209.
26. Crooke ST (2004) Progress in antisense technology. Annual Review of Medicine 55: 61-95. (Pubitemid 38316716)
27. Le May C, Berger JM, Pillot B, Prier X, Letessier E, et al. (2012) LDLR Promotes and PCSK9 Inhibits LDL-Derived Transintestinal Cholesterol Excretion. Arterioscler Thromb Vasc Biol 32: A22.
28. Cai SF, Kirby RJ, Howles PN, Hui DY (2001) Differentiation-dependent expression and localization of the class B type I scavenger receptor in intestine. J Lipid Res 42: 902-909. (Pubitemid 32545845)
29. Bura KS, Lord C, Marshall S, McDaniel A, Thomas G, et al. (2013) Intestinal SR-BI does not impact cholesterol absorption or transintestinal cholesterol efflux in mice. J Lipid Res 54: 1567-1577.