Identification of a novel anti-inflammatory compound, α-cubebenoate from Schisandra chinensis

Journal of Ethnopharmacology

Volumn 153, Issue 1, 2014, Pages 242-249

  Kang, Saeromi ^a   Lee, Kyoung Pil ^a   Park, Soo Jin ^a   Noh, Dae Young ^a   Kim, Jung Min ^a   Moon, Hyung Ryong ^a   Lee, Young Geun ^a   Choi, Young Whan ^a   Im, Dong Soon ^a  

^a Pusan National University   (South Korea)

Author keywords

Anti inflammation; COX 2; iNOS; Macrophages; Schisandra chinensis; Cubebenoate

Indexed keywords

ALPHA CUBEBENOATE; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; PROSTAGLANDIN E2; UNCLASSIFIED DRUG; ALPHA-CUBEBENOATE; SESQUITERPENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG STRUCTURE; ENZYME INDUCTION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PERITONITIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHISANDRA CHINENSIS; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; FRUIT; ISOLATION AND PURIFICATION; METABOLISM; SCHISANDRA;

SCHISANDRA CHINENSIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOTTING, WESTERN; CYCLOOXYGENASE 2; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; FRUIT; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C57BL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RNA, MESSENGER; SCHISANDRA; SESQUITERPENES, GUAIANE;

EID: 84897108086     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.02.027     Document Type: Article

References (35)

1. Belonosov, I.S., Konstantinov, A.A., 1959. The effect of Schisandra and Ginseng root upon capillary resistance. In: Proceedings of the Khabarovsk Medical Institute, vol. 42, pp. 60-62.
2. F.L. Chiu, and J.K. Lin Tomatidine inhibits iNOS and COX-2 through suppression of NF-κB and JNK pathways in LPS-stimulated mouse macrophages FEBS Lett. 582 2008 2407 2412
3. E.J. Cho, H.J. An, J.S. Shin, H.E. Choi, J. Ko, Y.W. Cho, H.M. Kim, J.H. Choi, and K.T. Lee Roxatidine suppresses inflammatory responses via inhibition of NF-κB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages J. Cell. Biochem. 112 2011 3648 3659
4. W. Cho, J.W. Nam, H.J. Kang, T. Windono, E.K. Seo, and K.T. Lee Zedoarondiol isolated from the rhizoma of Curcuma heyneana is involved in the inhibition of iNOS, COX-2 and pro-inflammatory cytokines via the downregulation of NF-κB pathway in LPS-stimulated murine macrophages Int. Immunopharmacol. 9 2009 1049 1057
5. Y.W. Choi, H.J. Kim, S.S. Park, J.H. Chung, H.W. Lee, S.O. Oh, B.S. Kim, J.B. Kim, H.Y. Chung, B.P. Yu, C.D. Kim, and S. Yoon Inhibition of endothelial cell adhesion by the new anti-inflammatory agent α-iso-cubebene Vasc. Pharmacol. 51 2009 215 224
6. H.Y. Chung, E.K. Lee, Y.J. Choi, J.M. Kim, D.H. Kim, Y. Zou, C.H. Kim, J. Lee, H.S. Kim, N.D. Kim, J.H. Jung, and B.P. Yu Molecular inflammation as an underlying mechanism of the aging process and age-related diseases J. Dent. Res. 90 2011 830 840
7. L.Y. Guo, T.M. Hung, K.H. Bae, E.M. Shin, H.Y. Zhou, Y.N. Hong, S.S. Kang, H.P. Kim, and Y.S. Kim Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill Eur. J. Pharmacol. 591 2008 293 299
8. G.J. Huang, S.S. Huang, and J.S. Deng Anti-inflammatory activities of inotilone from Phellinus linteus through the inhibition of MMP-9, NF-κB, and MAPK activation in vitro and in vivo PLoS One 7 2012 e35922
9. Y.S. Jung, S.K. Lee, C.Y. Ok, E.J. Cho, J.S. Park, Y.W. Choi, and Y.S. Bae Role of CXCR2 on the immune modulating activity of α-iso-cubebenol a natural compound isolated from the Schisandra chinensis fruit Biochem. Biophys. Res. Commun. 431 2013 433 436
10. J.I. Kang, S.C. Kim, S.C. Han, H.J. Hong, Y.J. Jeon, B. Kim, Y.S. Koh, E.S. Yoo, and H.K. Kang Hair-loss preventing effect of Grateloupia elliptica Biomol. Ther. 20 2013 118 124
11. O.H. Kang, J.G. Choi, J.H. Lee, and D.Y. Kwon Luteolin isolated from the flowers of Lonicera japonica suppresses inflammatory mediator release by blocking NF-κB and MAPKs activation pathways in HMC-1 cells Molecules 15 2010 385 398
12. J.E. Kim, S.G. Kim, J.S. Goo, Park da, J. Lee, Y.J. Hwang, I.S. Lee, H.R. Choi, S.I. Lee, Y.J. Oh, C.H. Choi, and Y.W. Hwang, D.Y. The α-iso-cubebenol compound isolated from Schisandra chinensis induces p53-independent pathway-mediated apoptosis in hepatocellular carcinoma cells Oncol. Rep. 28 2012 1103 1109
13. K.N. Kim, S.J. Heo, W.J. Yoon, S.M. Kang, G. Ahn, T.H. Yi, and Y.J. Jeon Fucoxanthin inhibits the inflammatory response by suppressing the activation of NF-κB and MAPKs in lipopolysaccharide-induced RAW 264.7 macrophages Eur. J. Pharmacol. 649 2010 369 375
14. K.S. Kim, D.S. Lee, G.S. Bae, S.J. Park, D.G. Kang, H.S. Lee, H. Oh, and Y.C. Kim The inhibition of JNK MAPK and NF-κB signaling by tenuifoliside A isolated from Polygala tenuifolia in lipopolysaccharide-induced macrophages is associated with its anti-inflammatory effect Eur. J. Pharmacol. 721 2013 267 276
15. S.C. Kim, S.H. Kang, S.J. Jeong, S.H. Kim, H.S. Ko, and S.H. Kim Inhibition of c-Jun N-terminal kinase and nuclear factor κB pathways mediates fisetin-exerted anti-inflammatory activity in lipopolysccharide-treated RAW264.7 cells Immunopharmacol. Immunotoxicol. 34 2012 645 650
16. H.N. Lee, J.K. Kundu, Y.N. Cha, and Y.J. Surh Resolvin D1 stimulates efferocytosis through p50/p50-mediated suppression of tumor necrosis factor-α expression J. Cell Sci. 126 2013 4037 4047
17. J.W. Lee, N.H. Kim, J.Y. Kim, J.H. Park, S.Y. Shin, Y.S. Kwon, H.J. Lee, S.S. Kim, and W.J. Chun Aromadendrin inhibits lipopolysaccharide-induced nuclear translocation of NF-κB and phosphorylation of JNK in RAW 264.7 macrophage cells Biomol. Ther. 21 2013 216 221
18. S.K. Lee, S.D. Kim, M. Kook, H.Y. Lee, J.S. Park, Y.H. Park, J.S. Kang, W.J. Jung, Y.W. Choi, and Y.S. Bae Therapeutic effects of α-iso-cubebenol, a natural compound isolated from the Schisandra chinensis fruit, against sepsis Biochem. Biophys. Res. Commun. 427 2012 547 552
19. Y.J. Lee, S.Y. Park, S.G. Kim, J. Park da, J.S. Kang, S.J. Lee, S. Yoon, Y.H. Kim, Y.S. Bae, and Y.W. Choi Identification of a novel compound that inhibits iNOS and COX-2 expression in LPS-stimulated macrophages from Schisandra chinensis Biochem. Biophys. Res. Commun. 391 2010 1687 1692
20. Y.J. Lee, J.W. Shim, Y.H. Park, H.Y. Lee, S.D. Kim, Y.W. Choi, and Y.S. Bae Identification of a novel compound that stimulates intracellular calcium increase and CXCL8 production in human neutrophils from Schisandra chinensis Biochem. Biophys. Res. Commun. 379 2009 928 932
21. G.T. Liu Pharmacological actions and clinical use of fructus schizandrae Chin. Med. J. (Engl.) 102 1989 740 749
22. M. Maes Inflammatory and oxidative and nitrosative stress pathways underpinning chronic fatigue, somatization and psychosomatic symptoms Curr. Opin. Psychiatry 22 2009 75 83
23. M.D. Mashkovskij Medicinal Drugs-Manual on Pharmacotherapy for Doctors 14th ed. 2000 New Wave Publishing House Moscow.
24. J. Michaud, D.S. Im, and T. Hla Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation J. Immunol. 184 2010 1475 1483
25. G. Morris, M. Berk, P. Galecki, and M. Maes The emerging role of autoimmunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs) Mol. Neurobiol. 2013
26. A. Panossian, and G. Wikman Pharmacology of Schisandra chinensis Bail.: an overview of Russian research and uses in medicine J. Ethnopharmacol. 118 2008 183 212
27. S.Y. Park, J. Park da, Y.H. Kim, Y. Kim, Y.W. Choi, and S.J. Lee Schisandra chinensis α-iso-cubebenol induces heme oxygenase-1 expression through PI3K/Akt and Nrf2 signaling and has anti-inflammatory activity in Porphyromonas gingivalis lipopolysaccharide-stimulated macrophages Int. Immunopharmacol. 11 2011 1907 1915
28. S.Y. Park, J. Park da, Y.H. Kim, Y. Kim, S.G. Kim, K.J. Shon, Y.W. Choi, and S.J. Lee Upregulation of heme oxygenase-1 via PI3K/Akt and Nrf-2 signaling pathways mediates the anti-inflammatory activity of Schisandrin in Porphyromonas gingivalis LPS-stimulated macrophages Immunol. Lett. 139 2011 93 101
29. S.Y. Park, T.G. Park, S.J. Lee, Y.S. Bae, M.J. Ko, and Y.W. Choi α-Iso-cubebenol inhibits inflammation-mediated neurotoxicity and amyloid β 1-42 fibril-induced microglial activation J. Pharm. Pharmacol. 66 1 2014 93 105
30. D.B. Reddy, and P. Reddanna Chebulagic acid (CA) attenuates LPS-induced inflammation by suppressing NF-κB and MAPK activation in RAW 264.7 macrophages Biochem. Biophys. Res. Commun. 381 2009 112 117
31. K.J. Senthil Kumar, and S.Y. Wang Lucidone inhibits iNOS and COX-2 expression in LPS-induced RAW 264.7 murine macrophage cells via NF-κB and MAPKs signaling pathways Planta Med. 75 2009 494 500
32. W.J. Yoon, S.J. Heo, S.C. Han, H.J. Lee, G.J. Kang, H.K. Kang, J.W. Hyun, Y.S. Koh, and E.S. Yoo Anti-inflammatory effect of sargachromanol G isolated from Sargassum siliquastrum in RAW 264.7 cells Arch. Pharm. Res. 35 2012 1421 1430
33. C.K. Youn, S.J. Park, M.Y. Lee, M.J. Cha, O.H. Kim, H.J. You, I.Y. Chang, S.P. Yoon, and Y.J. Jeon Silibinin inhibits LPS-induced macrophage activation by blocking p38 MAPK in RAW 264.7 cells Biomol. Ther. 21 2013 258 263
34. M.R. Yun, F. Okajima, and D.S. Im The action mode of lysophosphatidylcholine in human monocytes J. Pharmacol. Sci. 94 2004 45 50
35. H.Y. Zhou, E.M. Shin, L.Y. Guo, U.J. Youn, K. Bae, S.S. Kang, L.B. Zou, and Y.S. Kim Anti-inflammatory activity of 4-methoxyhonokiol is a function of the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-κB, JNK and p38 MAPK inactivation Eur. J. Pharmacol. 586 2008 340 349