Upregulation of heme oxygenase-1 via PI3K/Akt and Nrf-2 signaling pathways mediates the anti-inflammatory activity of Schisandrin in Porphyromonas gingivalis LPS-stimulated macrophages

Immunology Letters

Volumn 139, Issue 1-2, 2011, Pages 93-101

  Park, Sun Young ^a   Park, Da Jung ^a   Kim, Young Hun ^a   Kim, YoungHee ^a   Kim, Sun Gun ^a   Shon, Kwang Jae ^a   Choi, Young Whan ^a   Lee, Sang Joon ^a  

^a Pusan National University   (South Korea)

Author keywords

Heme oxygenase 1; NF B; Nrf 2; Porphyromonas gingivalis LPS; Pro inflammatory cytokine; Schisandrin

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; HEME OXYGENASE 1; HERBACEOUS AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SCHISANDRIN; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STRAIN; CONTROLLED STUDY; DOWN REGULATION; DRUG ISOLATION; DRUG PURIFICATION; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVATION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SCHISANDRA CHINENSIS; SCHISANDRACEAE; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CELL NUCLEUS; CYCLOOCTANES; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HEME OXYGENASE-1; INFLAMMATION; INFLAMMATION MEDIATORS; LIGNANS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-E2-RELATED FACTOR 2; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; POLYCYCLIC COMPOUNDS; PORPHYROMONAS GINGIVALIS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 79960698211     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2011.05.007     Document Type: Article

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