Identification of a novel compound that inhibits iNOS and COX-2 expression in LPS-stimulated macrophages from Schisandra chinensis

Biochemical and Biophysical Research Communications

Volumn 391, Issue 4, 2010, Pages 1687-1692

  Lee, You Jin ^a   Park, Sun Young ^a   Kim, Sun Gun ^a   Park, Da Jung ^a   Kang, Jum Soon ^a   Lee, Sang Joon ^a   Yoon, Sik ^b   Kim, Young Hun ^a   Bae, Yoe Sik ^c   Choi, Young Whan ^a  

^a Pusan National University   (South Korea)

^b Pusan National University School of Medicine   (South Korea)

^c Dong A University   (South Korea)

Author keywords

iso cubebenol; COX 2; iNOS; LPS; Macrophage; NF B

Indexed keywords

ALPHA ISO CUBEBENOL; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; ENDOTOXIN; HERBACEOUS AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROSTAGLANDIN E2; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACTERIAL INFECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG IDENTIFICATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SCHISANDRA CHINENSIS; SCHISANDRACEAE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; ENZYME INHIBITORS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; SCHISANDRA; TERPENES;

BACTERIA (MICROORGANISMS); SCHISANDRA CHINENSIS;

EID: 74449085913     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.12.131     Document Type: Article

References (25)

1. Chang G.T., Kang S.K., Kim J.H., Chung K.H., Chang Y.C., and Kim C.H. Inhibitory effect of the Korean herbal medicine, Dae-Jo-Whan, on platelet-activating factor-induced platelet aggregation. J. Ethnopharmacol. 102 (2005) 430-439
2. Choi Y.W., Takamatsu S., Khan S.I., Srinivas P.V., Ferreira D., Zhao J., and Khan I.A. Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans. J. Nat. Prod. 69 (2006) 356-359
3. Chen D.F., Zhang S.X., Xie L., Xie J.X., Chen K., Kashiwada Y., Zhou B.N., Wang P., Cosentino L.M., and Lee K.H. Anti-AIDS agents: XXVI. Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues. Bioorg. Med. Chem. 5 (1997) 1715-1723
4. Kuo Y.H., Kuo L.M., and Chen C.F. Four new C19 homolignans, schiarisanrins A, B, and D and cytotoxic schiarisanrin C, from Schizandra arisanensis. J. Org. Chem. 62 (1997) 6242-6245
5. Choi Y.W., Kim H.J., Park S.S., Chung J.H., Lee H.W., Oh S.O., Kim B.S., Kim J.B., Chung H.Y., Yu B.P., Kim C.D., and Yoon S. Inhibition of endothelial cell adhesion by the new anti-inflammatory agent alpha-iso-cubebene. Vascul. Pharmacol. 51 (2009) 215-224
6. Lee Y.J., Shim J.W., Lee Y.J., Park Y.H., Lee H.Y., Kim S.D., Choi Y.W., and Bae Y.S. Identification of a novel compound that stimulates intracellular calcium increase and CXCL8 production in human neutrophils from Schisandra chinensis. Biochem. Biophys. Res. Commun. 379 (2009) 928-932
7. Wu M.D., Huang R.L., Kuo L.M., Hung C.C., Ong C.W., and Kuo Y.H. The anti-HBsAg (human type B hepatitis, surface antigen) and anti-HBeAg (human type B hepatitis, e antigen) C18 dibenzocyclooctadiene lignans from Kadsura matsudai and Schizandra arisanensis. Chem. Pharm. Bull. (Tokyo) 51 (2003) 1233-1236
8. Chiu P.Y., Mak D.H., Poon M.K., and Ko K.M. In vivo antioxidant action of a lignin enriched extract of Schisandra fruit and an anthraquinone-containing extract of Polygonum root in comparison with schisandrin B and emodin. Planta Med. 68 (2002) 951-956
9. Yasukawa K., Ikeya Y., Mitsuhashi H., Iwasaki M., Aburada M., Nakagawa S., Takeuchi M., and Takido M. Gomisin A inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Oncology 49 (1992) 68-71
10. Kinne R.W., Brauer R., Stuhlmuller B., Palombo-Kinne E., and Burmester G.R. Macrophages in rheumatoid arthritis. Arthritis Res. 2 (2000) 189-202
11. MacMicking J., Xie Q.W., and Nathan C. Nitric oxide and macrophage function. Annu. Rev. Immunol. 15 (1997) 323-350
12. Liu S.F., and Malik A.B. NF-κB activation as a pathological mechanism of septic shock and inflammation. Am. J. Physiol. Lung Cell. Mol. Physiol. 290 (2006) L622-L645
13. Schmidt H.H., and Kelm M. Determination of nitrite and nitrate by Griess reaction. In: Feelisch M., and Stamler J.S. (Eds). Methods in Nitric Oxide Research (1996), Wiley, New York 491-497
14. 4 intoxication model. J. Ethnopharmacol. 67 (1999) 61-68
15. Bae Y.S., Yi H.J., Lee H.Y., Jo E.J., Kim J.I., Lee T.G., Ye R.D., Kwak J.Y., and Ryu S.H. Differential activation of formyl peptide receptor-like 1 by peptide ligands. J. Immunol. 171 (2003) 6807-6813
16. Lappas M., Permezel M., Georgiou H.M., and Rice G.E. Nuclear factor kappa B regulation of pro-inflammatory cytokines in human gestational tissues in vitro. Biol. Reprod. 67 (2002) 668-673
17. Baeuerle P.A., and Baltimore D. NF-kappa B: ten years after. Cell 87 (1996) 13-20
18. Park H.J., Lee H.J., Choi M.S., Son D.J., Song H.S., Song M.J., Lee J.M., Han S.B., Kim Y.S., and Hong J.T. JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappa B activation by melittin. J. Inflamm. 29 (2008) 5-7
19. Martel-Pelletier J., Pelletier J.P., and Fahmi H. Cyclooxygenase-2 and prostaglandins in articular tissues. Semin. Arthritis Rheum. 33 (2003) 155-167
20. Rudders S., Gaspar J., Madore R., Voland C., Grall F., Patel A., Pellacani A., Perrella M.A., Libermann T.A., and Oettgen P. ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-κB to regulate the inducible nitric-oxide synthase gene. J. Biol. Chem. 276 (2001) 3302-3309
21. Kuprash D.V., Udalova I.A., Turetskaya R.L., Kwiatkowski D., Rice N.R., and Nedospasov S.A. Similarities and differences between human and murine TNF promoters in their response to lipopolysaccharide. J. Immunol. 162 (1999) 4045-4052
22. Kim Y.H., Lee S.H., Lee J.Y., Choi S.W., Park J.W., and Kwon T.K. Triptolide inhibits murine-inducible nitric oxide synthase expression by down-regulating lipopolysaccharide-induced activity of nuclear factor-kappa B and c-Jun NH2-terminal kinase. Eur. J. Pharmacol. 494 (2004) 1-9
23. Moon D.O., Choi Y.H., Kim N.D., Park Y.M., and Kim G.Y. Anti-inflammatory effects of beta-lapachone in lipopolysaccharide-stimulated BV2 microglia. Int. Immunopharmacol. 7 (2007) 506-514
24. Kim J.H., Kim D.H., Baek S.H., Lee H.J., Kim M.R., Kwon H.J., and Lee C.H. Rengyolone inhibits inducible nitric oxide synthase expression and nitric oxide production by down-regulation of NF kappa B and p38 MAP kinase activity in LPS-stimulated RAW 264.7 cells. Biochem. Pharmacol. 71 (2006) 1198-1205
25. Pergola C., Rossi A., Dugo P., Cuzzocrea S., and Sautebin L. Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract. Nitric Oxide 15 (2006) 30-39