Silibinin inhibits LPS-induced macrophage activation by blocking p38 MAPK in RAW 264.7 cells

Biomolecules and Therapeutics

Volumn 21, Issue 4, 2013, Pages 258-263

  Youn, Cha Kyung ^a   Park, Seon Joo ^a   Lee, Min Young ^a   Cha, Man Jin ^a   Kim, Ok Hyeun ^a   You, Ho Jin ^a   Chang, In Youp ^a   Yoon, Sang Pil ^b   Jeon, Young Jin ^a  

^a Chosun University College of Medicine   (South Korea)

^b Jeju National University School of Medicine   (South Korea)

Author keywords

Macrophages; Nitric oxide; P38 MAPK; Silibinin

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NITRIC OXIDE; SILIBININ; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE; GENE EXPRESSION; INDUCIBLE NITRIC OXIDE SYNTHASE GENE; MACROPHAGE ACTIVATION; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOUSE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 84881062695     PISSN: 19769148     EISSN: 20054483     Source Type: Journal    
DOI: 10.4062/biomolther.2013.044     Document Type: Article

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