Anti-inflammatory activities of inotilone from Phellinus linteus through the inhibition of MMP-9, NF-κB, and MAPK activation in vitro and in vivo

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Huang, Guan Jhong ^a   Huang, Shyh Shyun ^a   Deng, Jeng Shyan ^b  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b ASIA UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; CATALASE; CYCLOOXYGENASE 2; GELATINASE B; GLUTATHIONE PEROXIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INOTILONE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CARRAGEENAN; FURAN DERIVATIVE; LIPOPOLYSACCHARIDE; MACROLIDE; MMP9 PROTEIN, MOUSE; NOS2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PAW EDEMA; PHELLINUS LINTEUS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; UPREGULATION; WESTERN BLOTTING; ANIMAL; BASIDIOMYCETES; CELL LINE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; EDEMA; INSTITUTE FOR CANCER RESEARCH MOUSE; MACROPHAGE; METABOLISM; MICROBIOLOGY; SIGNAL TRANSDUCTION;

INONOTUS LINTEUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BASIDIOMYCOTA; CARRAGEENAN; CELL LINE; EDEMA; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FURANS; LIPOPOLYSACCHARIDES; MACROLIDES; MACROPHAGES; MALE; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED ICR; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II;

EID: 84860659880     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035922     Document Type: Article

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