α-Iso-cubebenol inhibits inflammation-mediated neurotoxicity and amyloid beta 1-42 fibril-induced microglial activation

Journal of Pharmacy and Pharmacology

Volumn 66, Issue 1, 2014, Pages 93-105

  Park, Sun Young ^a   Park, Tae Gyeong ^a   Lee, Sang Joon ^a   Bae, Yoe Sik ^b   Ko, Min J ^a   Choi, Young Whan ^a  

^a Pusan National University   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

iso cubebenol; amyloid ; microglia; neuroinflammation; nuclear factor B; reactive oxygen species

Indexed keywords

ALPHA ISOCUBEBENOL; AMYLOID BETA PROTEIN[1-42]; ANTIINFLAMMATORY AGENT; CHEMOKINE; CYCLOOXYGENASE 2; CYTOKINE; GELATINASE B; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUROPROTECTIVE AGENT; PLANT EXTRACT; PROSTAGLANDIN E2; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; CELL ACTIVATION; CELL NUCLEUS; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FRUIT; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION;

AMYLOID Β; MICROGLIA; NEUROINFLAMMATION; NUCLEAR FACTOR-ΚB; REACTIVE OXYGEN SPECIES; Α-ISO-CUBEBENOL;

AMYLOID BETA-PEPTIDES; ANIMALS; CELL LINE; CELL SURVIVAL; CHEMOKINE CCL2; CYCLOOXYGENASE 2; DINOPROSTONE; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; INTERLEUKIN-6; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED ICR; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASES; NEUROPROTECTIVE AGENTS; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; SESQUITERPENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84891019534     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12160     Document Type: Article

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