Reprogramming the chemodiversity of terpenoid cyclization by remolding the active site contour of epi-isozizaene synthase

Biochemistry

Volumn 53, Issue 7, 2014, Pages 1155-1168

  Li, Ruiqiong ^a   Chou, Wayne K W ^b   Himmelberger, Julie A ^c   Litwin, Kevin M ^a   Harris, Golda G ^a   Cane, David E ^b   Christianson, David W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b BROWN UNIVERSITY   (United States)

^c DESALES UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC RESIDUES; CYCLIZATION PRODUCTS; CYCLIZATION REACTIONS; FARNESYL DIPHOSPHATE; HYDROPHOBIC ACTIVE SITES; ISOPRENOID SUBSTRATES; REACTION CASCADES; WILD-TYPE ENZYMES;

ENZYMES; HYDROPHOBICITY; LIPIDS;

CYCLIZATION;

BETA ACORADIENE SYNTHASE; BETA CEDRENE SYNTHASE; BETA CURCUMENE SYNTHASE; BETA FARNESENE; BETA FARNESENE SYNTHASE; EPI ISOZIZAENE SYNTHASE; GAMMA BISABOLENE SYNTHASE; SESQUITERPENE; SESQUITERPENE SYNTHASE; SYNTHETASE; TERPENOID; UNCLASSIFIED DRUG; ZIZAENE SYNTHASE;

ARTICLE; CRYSTAL STRUCTURE; CYCLIZATION; ENZYME ACTIVE SITE; MUTANT; MUTATION; PRIORITY JOURNAL; WILD TYPE;

BACTERIAL PROTEINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; STREPTOMYCES COELICOLOR; TERPENES;

EID: 84896870562     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi401643u     Document Type: Article

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