Biosynthesis of the sesquiterpene antibiotic albaflavenone in streptomyces coelicolor. mechanism and stereochemistry of the enzymatic formation of epi-isozizaene

Journal of the American Chemical Society

Volumn 131, Issue 18, 2009, Pages 6332-6333

  Lin, Xin ^a   Cane, David E ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE RESIDUES; BINDING DOMAIN; CATALYZED OXIDATION; CYTOCHROME P450; DEUTERATIONS; ENZYMATIC FORMATION; FARNESYL DIPHOSPHATE; GC-MS ANALYSIS; METHYL MIGRATIONS; MULTI-STEP; MUTANT PROTEINS; SESQUITERPENES; SITE DIRECTED MUTAGENESIS; STREPTOMYCES COELICOLOR; SYNTHASES; WILD TYPES;

ANTIBIOTICS; BIOCHEMISTRY; DEUTERIUM; ENZYME ACTIVITY; ENZYMES; HYDROCARBONS; QUENCHING; RAPID SOLIDIFICATION; STEREOCHEMISTRY;

CYCLIZATION;

ALBAFLAVENONE; ANTIBIOTIC AGENT; CATION; CYTOCHROME P450; DEUTERIUM; EPIISOZIZAENE; EPIISOZIZAENE SYNTHASE; FARNESYL DIPHOSPHATE; HYDROCARBON; MAGNESIUM; SESQUITERPENE DERIVATIVE; SYNTHETASE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; EPI-ISOZIZAENE; SESQUITERPENE;

ARTICLE; BINDING SITE; CHIRALITY; CYCLIZATION; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME MECHANISM; MASS FRAGMENTOGRAPHY; OXIDATION; PREDICTION; PROTON TRANSPORT; SITE DIRECTED MUTAGENESIS; STEREOCHEMISTRY; STREPTOMYCES COELICOLOR; WILD TYPE; BIOSYNTHESIS; BLOOD; METABOLISM; STEREOISOMERISM;

ANTI-BACTERIAL AGENTS; SESQUITERPENES; STEREOISOMERISM; STREPTOMYCES COELICOLOR;

EID: 69949157277     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja901313v     Document Type: Article

References (19)

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