Roots of biosynthetic diversity

Science

Volumn 316, Issue 5821, 2007, Pages 60-61

  Christianson, David W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; CHRYSANTHEMYL DIPHOSPHATE SYNTHASE; DIMETHYLALLYLDIPHOSPHATE; GERANYLTRANSFERASE; ISOPENTENYL DIPHOSPHATE; PHOSPHATE; SYNTHETASE; TERPENOID; TERPENOID SYNTHASE; UNCLASSIFIED DRUG; 3,3 DIMETHYLALLYL PYROPHOSPHATE; 3,3-DIMETHYLALLYL PYROPHOSPHATE; CHRYSANTHEMYL DIPHOSPHATE SYNTHASE, CHRYSANTHEMUM; HEMITERPENE; HYBRID PROTEIN; ORGANOPHOSPHORUS COMPOUND; TERPENE;

ENZYME ACTIVITY; EVOLUTION; ISOPRENOID; ORGANOPHOSPHATE;

ALPHA HELIX; BIODIVERSITY; BIOSYNTHESIS; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; AMINO ACID SUBSTITUTION; BINDING SITE; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR EVOLUTION; NOTE; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SUBSTITUTION; BINDING SITES; EVOLUTION, MOLECULAR; GERANYLTRANSTRANSFERASE; HEMITERPENES; ORGANOPHOSPHORUS COMPOUNDS; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; TERPENES;

EID: 34147124870     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1141630     Document Type: Short Survey

References (13)

1. D. E. Cane, Ed., Isoprenoids, Including Carotenoids and Steroids, vol. 2, Comprehensive Natural Products Chemistry, D. H. R. Barton, K. Nakanishi, O. Meth-Cohn, Eds. (Elsevier, Oxford, 1999).
2. J. C. Sacchettini, C. D. Poulter, Science 277, 1788 (1997).
3. H. V. Thulasiram, H. K. Erickson, C. D. Poulter, Science 316, 73 (2007).
4. L. C. Tarshis, M. Yan, C. D. Poulter, J. C. Sacchettini, Biochemistry 33, 10871 (1994).
5. D. J. Hosfield et al., J. Biol. Chem. 279, 8526 (2004).
6. J. Pandit et al., J. Biol. Chem. 275, 30610 (2000).
7. D. W. Christianson, Chem. Rev. 106, 3412 (2006).
8. D. A. Whittington et al., Proc. Natl. Acad. Sci. U.S.A. 99, 15375 (2002).
9. M. J. Rynkiewicz, D. E. Cane, D. W. Christianson, Proc. Natl. Acad. Sci. U.S.A. 99, 13543 (2001).
10. C. L. Steele, J. Crock, J. Bohlmann, R. Croteau, J. Biol. Chem. 273, 2078 (1998).
11. Y. Yoshikuni, T. E. Ferrin, J. D. Keasling, Nature 440, 1078 (2006).
12. B. T. Greenhagen, P. E. O'Maille, J. P. Noel, J. Chappell, Proc. Natl. Acad. Sci. U.S.A. 103, 9826 (2006).
13. I thank the NIH (grant GM56838) and the Biotechnology and Biological Sciences Research Council (UK) for the Underwood Fellowship supporting my study at the University of Cambridge. I am grateful to D. E. Cane and T. Blundell for stimulating scientific discussions and to L. Di Costanzo, H. A. Gennadios, E. Y. Shishova, L. S. Vedula, and T. Zakharian for assistance with the figures.