Role of arginine-304 in the diphosphate-triggered active site closure mechanism of trichodiene synthase

Biochemistry

Volumn 44, Issue 38, 2005, Pages 12719-12727

  Vedula, L Sangeetha ^a   Cane, David E ^b   Christianson, David W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; HYDROGEN BONDS; INORGANIC COMPOUNDS; STRUCTURAL ANALYSIS; X RAY ANALYSIS;

AZA ANALOGUES; BISABOLYL CARBOCATION INTERMEDIATE; FARNESYL DIPHOSPHATE; TRICHODIENE SYNTHASE;

ENZYME KINETICS;

ARGININE; AZABISABOLENE; BISABOLOL; FARNESYL DIPHOSPHATE; LYSINE; MAGNESIUM ION; PYROPHOSPHATE; RECOMBINANT ENZYME; SYNTHETASE; TERPENOID; TRICHODIENE SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; PRIORITY JOURNAL;

ARGININE; BINDING SITES; CARBON-CARBON LYASES; CRYSTALLOGRAPHY, X-RAY; CYCLOHEXYLAMINES; DIPHOSPHATES; HYDROGEN BONDING; MAGNESIUM; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION;

EID: 25444446571     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0510476     Document Type: Article

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