Identifying and manipulating structural determinates linking catalytic specificities in terpene synthases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 26, 2006, Pages 9826-9831

  Greenhagen, Bryan T ^a,c   O'Maille, Paul E ^b   Noel, Joseph P ^b   Chappell, Joe ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Phylogenetic relationships; Rational design; Sesquiterpene; Structure function

Indexed keywords

5 EPIARISTOLOCHENE SYNTHASE; AMINO ACID; EREMOPHILENE; FARNESYL DIPHOSPHATE; FARNESYL HYDROXYPHOSPHONATE; PREMNASPIRODIENE SYNTHASE; SESQUITERPENE; SYNTHETASE; TERPENE SYNTHASE; UNCLASSIFIED DRUG; VETISPIRANE;

ARTICLE; BIOSYNTHESIS; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME SPECIFICITY; ENZYME STRUCTURE; GAS CHROMATOGRAPHY; HYOSCYAMUS; MASS SPECTROMETRY; MOLECULAR EVOLUTION; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; TOBACCO;

ALKYL AND ARYL TRANSFERASES; AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; EVOLUTION, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION;

FUNGI;

EID: 33745631233     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0601605103     Document Type: Article

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