Evidence for differential folding of farnesyl pyrophosphate in the active site of aristolochene synthase: A single-point mutation converts aristolochene synthase into an (E)-β-farnesene synthase

Biochemistry

Volumn 42, Issue 25, 2003, Pages 7741-7747

  Deligeorgopoulou, Athina ^a   Allemann, Rudolf K ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENERGETIC SEPARATION;

CATALYSTS; CHEMICAL BONDS; CONFORMATIONS; ENZYMES; X RAY ANALYSIS;

BIOCHEMISTRY;

7BETA,10ALPHA SELINA 4,11 DIENE; ALANINE; ALPHA FARNESENE; ALPHA SELINENE; ARISTOLOCHENE SYNTHASE; BETA BISABOLENE; BETA FARNESENE; BETA FARNESENE SYNTHASE; DECALIN; FARNESYL DIPHOSPHATE; GERMACRENE A; GERMACRENE D; HYDROCARBON; MUTANT PROTEIN; SELINENE; SESQUITERPENE DERIVATIVE; SYNTHETASE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CIS ISOMER; CYCLIZATION; ENERGY TRANSFER; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME MODIFICATION; MOLECULAR WEIGHT; NONHUMAN; PENICILLIUM ROQUEFORTI; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; STEREOSPECIFICITY;

CIRCULAR DICHROISM; ISOMERASES; PENICILLIUM; POINT MUTATION; POLYISOPRENYL PHOSPHATES; STRUCTURE-ACTIVITY RELATIONSHIP;

PENICILLIUM; PENICILLIUM ROQUEFORTII;

EID: 0038677917     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034410m     Document Type: Article

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