Simplified 2-aminoquinoline-based scaffold for potent and selective neuronal nitric oxide synthase inhibition

Journal of Medicinal Chemistry

Volumn 57, Issue 4, 2014, Pages 1513-1530

  Cinelli, Maris A ^a   Li, Huiying ^b   Chreifi, Georges ^b   Martásek, Pavel ^c,d   Roman, Linda J ^c   Poulos, Thomas L ^b   Silverman, Richard B ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d CHARLES UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOQUINOLINE; AMINOPYRIDINE DERIVATIVE; ARGININE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE;

ANIMAL CELL; ARTICLE; CELL STRAIN CACO 2; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG PENETRATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; NONHUMAN; X RAY CRYSTALLOGRAPHY;

AMINOQUINOLINES; CATALYTIC DOMAIN; ENZYME INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, MOLECULAR; NITRIC OXIDE SYNTHASE TYPE I;

EID: 84896823372     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401838x     Document Type: Article

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