Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 5, 2013, Pages 1333-1343

  Li, Huiying ^a   Xue, Fengtian ^b   Kraus, James M ^b   Ji, Haitao ^b   Labby, Kristin Jansen ^b   Mataka, Jan ^b   Delker, Silvia L ^a   Martásek, Pavel ^c,d   Roman, Linda J ^c   Poulos, Thomas L ^a   Silverman, Richard B ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Cyclopropyl analogues; Inhibition; Isozyme selectivity; Neuronal nitric oxide synthase; X ray crystallography

Indexed keywords

2 (3 CHLOROPHENYL)CYCLOPROPANECARBOXYLIC ACID; 2 (3 FLUOROPHENYL)CYCLOPROPANAMINE; 2 (3 FLUOROPHENYL)CYCLOPROPANECARBOXYLIC ACID; 2 TOLYLCYCLOPROPANECARBOXYLIC ACID; 4 METHYL 6 [4 [2 [(2 TOLYLCYCLOPROPYLAMINO)ETHOXY]PYRROLIDIN 3 YL]METHYL]PYRIDIN 2 AMINE; 6 [4 [2 [1 [(3 FLUOROPHENYL)PROPAN 2 YL]ETHOXY]PYRROLIDIN 3 YL]METHYL] 4 METHYLPYRIDIN 2 AMINE; 6 [4 [2 [2 [(3 CHLOROPHENYL) CYCLOPROPYLAMINO]ETHOXY]PYRROLIDIN 3 YL]METHYL] 4 METHYLPYRIDIN 2 AMINE; 6 [4 [2 [2 [(3 FLUOROPHENYL) CYCLOPROPYLAMINO]ETHOXY]PYRROLIDIN 3 YL]METHYL] 4 METHYLPYRIDIN 2 AMINE; AMINO ACID DERIVATIVE; CYCLOPROPANE DERIVATIVE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; TERT BUTYL 2 (3 CHLOROFLUOROPHENYL)CYCLOPROPYLCARBAMATE; TERT BUTYL 2 (3 FLUOROPHENYL)CYCLOPROPYLCARBAMATE; TERT BUTYL 2 TOLYLCYCLOPROPYLCARBAMATE; TERT BUTYL 3 [[6 [BENZYL(TERT BUTOXYCARBONYL) AMINO] 4 METHYLPYRIDIN 2 YL]METHYL] 4 [2 [[(TERT BUTOXYCARBONYL) 2 (3 FLUOROPHENYL)CYCLOPROPYL]AMINO]ETHOXY] PYRROLIDINE 1 CARBOXYLATE; TERT BUTYL 3 [[6 [BIS(TERT BUTOXYCARBONYL) AMINO] 4 METHYLPYRIDIN 2 YL]METHYL] 4 [2 (2 TOLYLCYCLOPROPYLAMINO)ETHOXY]PYRROLIDINE 1 CARBOXYLATE; TERT BUTYL 3 [[6 [BIS(TERT BUTOXYCARBONYL) AMINO] 4 METHYLPYRIDIN 2 YL]METHYL] 4 [2 [2 (3 CHLOROPHENYL)CYCLOPROPYLAMINO]ETHOXY]PYRROLIDINE 1 CARBOXYLATE; TERT BUTYL 3 [[6 [BIS(TERT BUTOXYCARBONYL) AMINO] 4 METHYLPYRIDIN 2 YL]METHYL] 4 [2 [2 (3 FLUOROPHENYL)CYCLOPROPYLAMINO]ETHOXY]PYRROLIDINE 1 CARBOXYLATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CURTIUS REARRANGEMENT; CYCLOPROPANATION; DEPROTECTION REACTION; DRUG DESIGN; DRUG DETERMINATION; DRUG HYDROLYSIS; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRON; ENZYME ASSAY; EPIMERIZATION; IN VITRO STUDY; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYCLOPROPANES; ENZYME INHIBITORS; MICE; MOLECULAR DOCKING SIMULATION; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE III; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84873712465     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.12.019     Document Type: Article

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