Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model

Journal of the American Chemical Society

Volumn 132, Issue 15, 2010, Pages 5437-5442

  Delker, Silvia L ^a   Ji, Haitao ^b   Li, Huiying ^a   Jamal, Joumana ^a   Fang, Jianguo ^b   Xue, Fengtian ^b   Silverman, Richard B ^b   Poulos, Thomas L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ANIMAL MODEL; BINDING MODES; BRAIN INJURY; CEREBRAL PALSY; HOT SPOT; ISOFORMS; NEURODEGENERATIVE DISORDERS; NITRIC OXIDE SYNTHASE INHIBITORS; NITRIC-OXIDE SYNTHASE; SELECTIVE INHIBITION; SELECTIVE INHIBITORS; SITE DIRECTED MUTAGENESIS; STRUCTURAL BASIS; STRUCTURAL CHANGE;

BINDING ENERGY; CRYSTALLOGRAPHY; NITRIC OXIDE; STEREOCHEMISTRY;

ENZYMES;

NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL CELL; ARTICLE; CEREBRAL PALSY; CHIRALITY; CONTROLLED STUDY; ELASTICITY; ENZYME INHIBITION; EXPERIMENTAL MODEL; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN BINDING; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

ANIMALS; CEREBRAL PALSY; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; MICE; MODELS, ANIMAL; MODELS, MOLECULAR; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE III;

EID: 77951040002     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja910228a     Document Type: Article

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