Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 6, 2009, Pages 2371-2380

  Lawton, Graham R ^a   Ranaivo, Hantamalala Ralay ^a   Chico, Laura K ^a   Ji, Haitao ^a   Xue, Fengtian ^a   Martásek, Pavel ^b,c   Roman, Linda J ^b   Martin Watterson, D ^a   Silverman, Richard B ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Aminopyridine; Bioavailability; Blood brain barrier; Ether; Neuronal nitric oxide synthase; Neuronal nitric oxide synthase inhibitors

Indexed keywords

2 AMINOPYRIDINE DERIVATIVE; 6 [[4 [2 (3 FLUOROPHENETHYLAMINO)ETHOXY]PYRROLIDIN 3 YL]METHYL] 4 METHYLPYRIDIN 2 AMINE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG PENETRATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSPORT; HYDROGEN BOND; MOUSE; NONHUMAN; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ALKYLATION; AMINATION; AMINOPYRIDINES; ANIMALS; BIOLOGICAL AVAILABILITY; BLOOD-BRAIN BARRIER; ENZYME INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; NITRIC OXIDE SYNTHASE TYPE I; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 62149098014     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.02.017     Document Type: Article

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